Leptospires are killed in vitro by both oxygen-dependent and -independent reactions

Infection and Immunity

Volumn 70, Issue 12, 2002, Pages 7172-7175

  Murgia, Rossella ^a   Garcia, Rodolfo ^b   Cinco, Marina ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MYELOPEROXIDASE; OXYGEN;

ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; GRANULE CELL; HALOGENATION; IN VITRO STUDY; LEPTOSPIRA; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

BLOOD BACTERICIDAL ACTIVITY; HUMANS; HYDROGEN PEROXIDE; LEPTOSPIRA; NEUTROPHILS; OXYGEN; PEROXIDASE; SUBCELLULAR FRACTIONS;

EID: 0036892187     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.12.7172-7175.2002     Document Type: Article

References (22)

1. Banfi, E., M. Cinco, M. Bellini, and M. R. Soranzo. 1982. The role of antibodies and complement in the interaction between macrophages and leptospires. J. Gen. Microbiol. 128:813-816.
2. Banfi, E., M. Cinco, and P. Dri. 1981. Catalase activity among leptospires. Experientia 37:147-148.
3. Borregaard, N., J. M. Heiple, E. R. Simons, and R. A. Clark. 1983. Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase. J. Cell Biol. 97:52-61.
4. Bortolussi, R., C. M. Vandenbroucke-Grauls, B. S. van Asbeck, and J. Verhoef. 1987. Relationship of bacterial growth phase to killing of Listeria monocytogenes by oxidative agents generated by neutrophils and enzyme systems. Infect. Immun. 55:3197-3203.
5. Cinco, M., and E. Banfi. 1983. Interactions between human polymorphonu-clear leukocytes and one strain of pathogenic Leptospira (L. interrogans sp.) and one strain of saprophytic Leptospira (L. biflexa sp.). FEMS Microbiol. Lett. 19:51-54.
6. Cinco, M., and E. Banfi. 1983. Activation and bactericidal activity of complement by leptospires. Zentbl. Bakteriol. Hyg. Abt. 1 Orig. A 254:261-265.
7. Cinco, M., E. Banfi, and M. R. Soranzo. 1981. Studies on the interaction between macrophages and leptospires. J. Gen. Microbiol. 124:409-413.
8. 2 diffusion through lysosome. Isr. J. Chem. 23:442-445.
9. Gabay, J. E. 1994. Antimicrobial proteins with homology to serine proteases. Ciba Found. Symp. 186:237-247.
10. Ganz, T., and R. I. Lehrer. 1998. Antimicrobial peptides of vertebrates. Curr. Opin. Immunol. 10:41-44.
11. Garcia, R., L. Gusmani, R. Murgia, C. Guarnaccia, M. Cinco, and G. Rottini. 1998. Elastase is the only human neutrophil granule protein that alone is responsible for in vitro killing of Borrelia burgdorferi. Infect. Immun. 66:1408-1412.
12. Jepras, R. I., and R. B. Fitzgeorge. 1986. The effect of oxygen-dependent antimicrobial systems on strains of Legionella pneumophila of different virulence. J. Hyg. Camb. 97:61-69.
13. Klebanoff, S. J. 1988. Phagocytic cells: products of oxygen metabolism, p. 391-444. In J. Gallin, I. M. Goldstein, and R. Snyderman (ed.), Inflammation: Basic Principles and Clinical Correlates. Raven Press Ltd., New York, N.Y.
14. Klempner, M. S., R. B. Mikkelsen, D. H. Corfman, and J. Andre-Schwartz. 1980. Neutrophil plasma membranes. I. High-yield purification of human neutrophil plasma membrane vesicles by nitrogen cavitation and differential centrifugation. J. Cell Biol. 86:21-28.
15. Lehrer, R. I., and T. Ganz. 1990. Antimicrobial peptides of human neutrophils. Blood 76:2169-2181.
16. Marangoni, A., R. Aldini, V. Sambri, M. Montagnani, G. Ballardini, E. Sturni, and R. Cevenini. 2000. Uptake and killing of Leptospira interrogans and Borrelia burgdorferi, spirochetes pathogenic for humans, by reticuloendothelial cells in perfused rat liver. Infect. Immun. 68:5408-5411.
17. Meynell, G. G., and E. Meynell. 1970. Theory and Practice in Experimental Bacteriology, p. 231-232. Cambridge University Press, Cambridge, United Kingdom.
18. Miller, R. A., and B. E. Britigan. 1997. Role of oxidants in microbial pathophysiology. Clin. Microbiol. Rev. 10:1-18.
19. Pacelli, R., D. A. Wink, J. A. Cook, M. C. Krisha, W. De Graff, N. Friedman, M. Tsokos, A. Samuni, and J. B. Mitchell. 1995. Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli. J. Exp. Med. 182:1469-1479.
20. Wang, B., J. Sullivan, G. W. Sullivan, and G. Mandell. 1984. Interaction of leptospires with human polymorphonuclear neutrophils. Infect. Immun. 44:459-464.
21. Wilson, C. B., and W. M. Weaver. 1985. Comparative susceptibility of group B streptococci and Staphylococcus aureus to killing by oxygen metabolites. J. Infect. Dis. 152:323-329.
22. Wu, Q., L. Xu, X. Wang, S. Li, and B. Wang. 1992. Investigation of microbicidal activity of neutrophil defensins against leptospires. Huaxi Yike Daxue Xuebao 23:126-129.