Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients

Journal of Affective Disorders

Volumn 72, Issue 3, 2002, Pages 249-255

  Bhagwagar, Zubin ^a   Hafizi, Sepehr ^a   Cowen, P J ^a  

^a WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

Cortisol; Depression; Growth hormone; Serotonin; Tryptophan

Indexed keywords

GROWTH HORMONE; HYDROCORTISONE; PLACEBO; SEROTONIN; TRYPTOPHAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE PREDISPOSITION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HUMAN; MAJOR DEPRESSION; MALE; NEUROTRANSMISSION; PRIORITY JOURNAL; RECURRENT DISEASE; REGULATORY MECHANISM;

ADULT; ANTI-INFLAMMATORY AGENTS; CROSS-OVER STUDIES; DEPRESSIVE DISORDER; FEMALE; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; NEUROTRANSMITTER AGENTS; PLACEBOS; SEROTONIN; STRESS, PSYCHOLOGICAL;

EID: 0036890426     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0327(01)00467-0     Document Type: Article

References (17)

1. Badawi A.A. Possible involvement of the enhanced tryptophan pyrrolase activity in the corticosterone- and starvation-induced increases in concentrations of nicotinamide-adenine dinucleotides (phosphates) in rat liver. Biochem. J. 196:1981;217-224.
2. Cowen P.J. Back to the future: The neurobiology of major depression. Psychol. Med. 28:1998;253-255.
3. Deakin J.F.W., Pennell I., Upadhyaya A.J., Lofthouse R. A neuroendocrine study of 5-HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology. 101:1990;85-92.
4. Deakin J.F.W., Graeff F.G. 5-HT and mechanisms of defence. J. Psychopharmacol. 5:1991;305-315.
5. Dinan T.G. Glucocorticoids and the genesis of depressive illness: a psychobiological model. Br. J. Psychiatry. 164:1994;365-371.
6. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology. 23:2000;477-501.
7. Frank E., Prien R.F., Jarrett R.B., Keller M.B., Kupfer D.J., Lavori P.W., Rush A.J., Weissman M.M. Conceptualisation and rationale for consensus definition of terms in major depressive disorder: remission, recovery, relapse and recurrence. Arch. Gen. Psychiatry. 48:1991;851-855.
8. Korte-Bouws G.A.H., Korte S.M., De Kloet E.R., Bohus B. Blockade of corticosterone synthesis reduces serotonin turnover in the dorsal hippocampus of the rat as measured by microdialysis. J. Neuroendocrinol. 8:1996;877-881.
9. Meltzer H., Nash J.F. Serotonin and mood: neuroendocrine aspects. Ganten D., Pfaff D., Current topics in neuroendocrinology. 1988;183-210 Springer, Berlin.
10. O'Dwyer A.M., Lightman S.L., Marks M.N., Checkley S.A. Treatment of major depression with metyrapone and hydrocortisone. J. Affect. Disord. 33:1995;123-128.
11. Porter R.J., McAllister-Williams R.H., Lunn B.S., et al. 5-Hydroxytryptamine receptor function in humans is reduced by acute administration of hydrocortisone. Psychopharmacology. 139:1998;243-250.
12. Rheus V.I., Wolkowitz O.M., Frederick S. Antiglucorticoid treatments in psychiatry. Psychoneuroendocrinology. 22:(Suppl.):1997;S121-S124.
13. Smith C.E., Ware C.J., Cowen P.J. Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan. Psychopharmacology. 103:1991;140-142.
14. Smith K.A., Williams C., Cowen P.J. Impaired regulation of brain serotonin function during dieting in women recovered from depression. Br. J. Psychiatry. 176:2000;72-75.
15. Upadhyaya A.K., Pennell I., Cowen P.J., Deakin J.F.W. Blunted growth hormone and prolactin responses to L-tryptophan in depression: a state-dependent abnormality. J. Affect. Disord. 21:1991;213-218.
16. Watson S.J., Porter R.J., Young A.H. Effect of hydrocortisone on the pituitary response to growth hormone releasing hormone. Psychopharmacology (Berl.). 152:2000;40-46.
17. Young A.H., MacDonald L.M., St John H., Dick H., Goodwin G.M. The effects of corticosterone on 5-HT receptor function in rodents. Neuropharmacology. 31:1992;433-438.