Synthesis of (+)-Lasonolide A: (-)-Lasonolide A is the biologically active enantiomer

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 24, 2002, Pages 3519-3520

  Lee, Eun ^a   Song, Ho Young ^a   Joo, Jung Min ^a   Kang, Jung Won ^a   Kim, Dae Shik ^a   Jung, Cheol Kyu ^a   Hong, Chang Yong ^b   Jeong, ShinWu ^b   Jeon, Kiwan ^b  

^a Seoul National University   (South Korea)

^b LG Life Sciences   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

LASONOLID A; MACROLIDE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; LASONOLIDE A;

ARTICLE; BIOASSAY; DRUG SYNTHESIS; ENANTIOMER; OPTICAL ROTATION; SPECTROSCOPY; CELL CULTURE; CELL DIVISION; CHEMISTRY; DRUG EFFECT; HUMAN; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL DIVISION; HUMANS; MACROLIDES; OPTICAL ROTATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0036890340     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00821-1     Document Type: Article

References (5)

1. Horton P.A., Koehn F.E., Longley R.E., McConnell O.J. J. Am. Chem. Soc. 116:1994;6015.
2. Lee E., Song H.Y., Kang J.W., Kim D.-S., Jung C.-K., Joo J.M. J. Am. Chem. Soc. 124:2002;384.
3. 50 value of the natural lasonolide A against the A-549 human lung carcinoma cell line was reported to be 40 ng/mL (∼0.06 μM).
4. Wu L., Smythe A.M., Stinson S.F., Mullendore L.A., Monks A., Scudiero D.A., Paull K.D., Koutsoukos A.D., Rubinstein L.V., Boyd M.R., Shoemaker R.H. Cancer Res. 52:1992;3029.
5. 2.