Variability of contractile reserve in hibernating myocardium: Dependence on the method of inotropic stimulation

Cardiovascular Research

Volumn 56, Issue 3, 2002, Pages 422-432

  Malm, Brian J ^b   Suzuki, Gen ^b   Canty Jr , John M ^a,b   Fallavollita, James A ^a,b  

^a VA Western New York Health Care System   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Adrenergic (ant)agonists; Contractile function; Hibernation; Inotropic agents; Regional blood flow

Indexed keywords

ADRENALIN;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY OBSTRUCTION; DRUG EFFECT; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE WALL; HEMODYNAMIC MONITORING; INOTROPISM; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIOTONIC AGENTS; DRUG ADMINISTRATION SCHEDULE; EPINEPHRINE; HEMODYNAMIC PROCESSES; MYOCARDIAL CONTRACTION; MYOCARDIAL STUNNING; REGIONAL BLOOD FLOW; STIMULATION, CHEMICAL; SWINE;

EID: 0036889806     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00599-0     Document Type: Article

References (25)

1. Bax J.J., Wijns W., Cornel J.H., et al. Accuracy of currently available techniques for prediction of functional recovery after revascularization in patients with left ventricular dysfunction due to chronic coronary artery disease: comparison of pooled data. J Am Coll Cardiol. 30:1997;1451-1460.
2. Sawada S., Elsner G., Segar D.S., et al. Evaluation of patterns of perfusion and metabolism in dobutamine-responsive myocardium. J Am Coll Cardiol. 29:1997;55-61.
3. Melon P.G., de Landsheere C.M., Degueldre C., et al. Relation between contractile reserve and positron emission tomographic patterns of perfusion and glucose utilization in chronic ischemic left ventricular dysfunction: implications for identification of myocardial viability. J Am Coll Cardiol. 30:1997;1651-1659.
4. Tawakol A., Skopicki H.A., Abraham S.A., et al. Evidence of reduced resting blood flow in viable myocardial regions with chronic asynergy. J Am Coll Cardiol. 36:2000;2146-2153.
5. 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium: Evidence for transmural variations in chronic hibernating myocardium. Circulation. 95:1997;1900-1909.
6. 2+ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium. Am J Physiol. 277:1999;H1418-H1428.
7. 18F-2-deoxyglucose uptake in pigs with hibernating myocardium. Circulation. 102:2000;908-914.
8. Fallavollita J.A., Logue M., Canty J.M. Jr. Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: Absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve. J Am Coll Cardiol. 37:2001;1989-1995.
9. Fallavollita J.A., Canty J.M. Jr. Ischemic cardiomyopathy in pigs with two-vessel occlusion and viable, chronically dysfunctional myocardium. Am J Physiol. 282:2002;H1370-H1379.
10. Glenny R.W., Bernard S., Brinkley M. Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. J Appl Physiol. 74:1993;2585-2597.
11. 201Tl tomography versus dobutamine echocardiography. Circulation. 94:1996;2712-2719.
12. 18F]fluorodeoxyglucose in patients with chronic coronary artery disease: A functional and morphological approach to the detection of residual myocardial viability. Circulation. 91:1995;1006-1015.
13. Lauerma K., Niemi P., Hanninen H., et al. Multimodality M.R. imaging assessment of myocardial viability: combination of first-pass and late contrast enhancement to wall motion dynamics and comparison with FDG PET: initial experience. Radiology. 217:2000;729-736.
14. Skopicki H.A., Abraham S.A., Weissman N.J., et al. Factors influencing regional myocardial contractile response to inotropic stimulation: Analysis in humans with stable ischemic heart disease. Circulation. 94:1996;643-650.
15. Barillà F., De Vincentis G., Mangieri E., et al. Recovery of contractility of viable myocardium during inotropic stimulation is not dependent on an increase of myocardial blood flow in the absence of collateral filling. J Am Coll Cardiol. 33:1999;697-704.
16. Indolfi C., Piscione F., Perrone-Filardi P., et al. Inotropic stimulation by dobutamine increases left ventricular regional function at the expense of metabolism in hibernating myocardium. Am Heart J. 132:1996;542-549.
17. Fallavollita J.A., Canty J.M. Jr. Metabolic reserve despite chronic reductions in resting flow, function and oxygen consumption in hibernating myocardium [Abstract]. Circulation. 104:2001;II-265.
18. Schulz R., Guth B.D., Pieper K.M., Martin C., Heusch G. Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery: A model of short-term hibernation. Circ Res. 70:1992;1282-1295.
19. Lohse M.J., Engelhardt S., Danner S., Bohm M. Mechanisms of beta-adrenergic receptor desensitization: from molecular biology to heart failure. Basic Res Cardiol. 91:(Suppl 2):1996;29-34.
20. Ito B.R. Gradual onset of myocardial ischemia results in reduced myocardial infarction: Association with reduced contractile function and metabolic downregulation. Circulation. 91:1995;2058-2070.
21. Berman M., Fischman A.J., Southern J., et al. Myocardial adaptation during and after sustained, demand-induced ischemia: Observations in closed-chest, domestic swine. Circulation. 94:1996;755-762.
22. Shan K., Bick R.J., Poindexter B.J., et al. Altered adrenergic receptor density in myocardial hibernation in humans. A possible mechanism of depressed myocardial function. Circulation. 102:2000;2599-2606.
23. Schulz R., Rose J., Martin C., Brodde O.-E., Heusch G. Development of short-term myocardial hibernation: Its limitation by the severity of ischemia and inotropic stimulation. Circulation. 88:1993;684-695.
24. Chen C., Li L., Chen L.L., et al. Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Circulation. 92:1995;756-766.
25. Weissman N.J., Nidorf S.M., Guerrero J.L., Weyman A.E., Picard M.H. Optimal stage duration in dobutamine stress echocardiography. J Am Coll Cardiol. 25:1995;605-609.