Lack of effects of oxolinic acid on spermatogenesis in young adult and aged Wistar rats

Food and Chemical Toxicology

Volumn 40, Issue 12, 2002, Pages 1815-1825

  Yoshida, M ^a   Kitani, T ^a   Takenaka, A ^a   Kudoh, K ^a   Katsuda, S I ^a   Taya, K ^b   Kurokawa, Y ^a   Maekawa, A ^a  

^a SASAKI INSTITUTE   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Leydig cell; Oxolinic acid; Rat; Spermatogenesis; Tubular atrophy

Indexed keywords

LUTEINIZING HORMONE; OXOLINIC ACID; TESTOSTERONE;

ADOLESCENT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL TISSUE; ARTICLE; CELL HYPERPLASIA; CELL PROLIFERATION; CONTROLLED STUDY; DIETARY INTAKE; HISTOPATHOLOGY; LEYDIG CELL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MORPHOMETRICS; NONHUMAN; RAT; RAT STRAIN; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SPERMATOGENESIS; TESTOSTERONE BLOOD LEVEL;

AGING; ANIMALS; ANTI-INFECTIVE AGENTS, URINARY; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; OXOLINIC ACID; RATS; RATS, WISTAR; SEMINIFEROUS TUBULES; SPERMATOGENESIS; TESTIS; TIME FACTORS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0036888130     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(02)00168-0     Document Type: Article

References (23)

1. Boorman G.A., Chapin R.E.K. Testis and epididymis. Boorman G.A., Eustis S.L., Elwell M.R., Montgomery C.A. Jr., MacKenzie W.F. Pathology of the Fischer Rat. 1990;405-418 Academic Press, San Diego.
2. Chatani F., Nonoyama T., Sudo K., Miyajima H., Takeyama M., Takatsuka D., Mori H., Matsumoto K. Stimulatory effect of lutenizing hormone on the development and maintenance of 5-reduced steroid-producing testicular interstitial cell tumors in Fischer 344 rats. Anticancer Research. 10:1990;337-342.
3. Chatani F., Suzuki S., Hamajima T., Orita S. Age-related changes in serum LH and testosterone in 5-110 week-old male F344, Wistar and Sprague-Dawley rats. Journal of Takeda Research Laboratory. 55:1996;188-200.
4. Clermont Y. Kinetics of spermatogenesis in mammals. seminiferous epithelium cycle and spermatogonial renewal Physiological Reviews. 52:1972;198-236.
5. Cozzarelli N.R. DNA gyrase and the supercoiling of DNA. Science. 207:1980;953-960.
6. Dickerman S., Kledzik G., Gelato M., Chen H.J., Meites J. Effects of haloperidol on serum and pituitary prolactin, LH and FSH, and hypothalamic PIF and LRF. Neuroendocrinology. 15:1974;10-20.
7. Fort F.L., Miyajima H., Ando T., Suzuki T., Yamamoto M., Hamashima T., Sato S., Kitazaki T., Mahony M.C., Hodgen G.D. Mechanism for species-specific induction of Leydig cell tumors in rats by lansoprazole. Fundamental and Applied Toxicology. 26:1995;191-202.
8. Gleckman R., Alvarez S., Joubert D.W., Matthew S.J. Drug therapy reviews. oxolinic acid American Journal of Hospital and Pharmacology. 36:1979;1077-1079.
9. Hamada Y., Futamura Y. Induction of Leydig cell tumors by lacidipine via up-regulation of the LHRH receptor of Leydig cells in rats. Journal of Toxicological Sciences. 123:1998;35-52.
10. Hikichi Y., Noda C., Shimizu K. Oxolinic acid. Japan Pesticide Information. 55:1989;21-23.
11. Hosokawa S., Murakami M., Ineyama M., Yamada T., Koyama Y., Okuno Y., Yoshitake A., Yamada H., Miyamoto J. Effects of procymidone on reproductive organs and serum gonadotropins in male rats. Journal of Toxicological Sciences. 18:1993;111-124.
12. Kohge S., Hagi S., Utsumi H., Takegawa K., Takagi H., Nagaoka T., Takeuchi M., Hanada S. Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 6)2- and 4-weeks administration study of haloperidol. Journal of Toxicological Sciences. 25 (Special Issue):2000;71-77.
13. Mohr U, (Ed in chief), 1997. Testis. In: International Classification of Rodent Tumors. Part 1. The Rat. 8. Male Genital System. IARC Scientific Publications No. 122. International Agency for Research on Cancer, Lyon, pp. 1-22.
14. Murakami M., Hosokawa S., Yamada T., Harakawa M., Ito M., Koyama K., Kimura J., Yoshitake A., Yamada H. Species-specific mechanism in rat Leydig cell tumorigenesis by procymidone. Toxicology and Applied Pharmacology. 131:1995;244-252.
15. Osheroff N., Shelton E.R., Brutlag D.L. DNA topoisomerase from Drosophila melanogaster. Journal of Biological Chemistry. 258:1983;9536-9543.
16. Roberts S.A., Nett T.M., Hartman H.A., Adams T.E., Stoll R.E. SDZ 200-100 induces Leydig cell tumors by increasing gonadotropins in rats. Journal of the American College of Toxicology. 8:1989;487-505.
17. Russell L.D. The Sertoli cell. Russell L.D., Ettlin R.A., Hikim A.P.S., Clegg E. D (Eds.), Histological and Histopathological Evaluation of the Testes. 1990;29-36 Cache River Press, FL.
18. Takahashi M., Matsui H. Mechanisms of testicular toxicity. Journal of Toxicologic Pathology. 6:1993;161-174.
19. Takayama S., Akaike M., Kawashima K., Takahashi M., Kurokawa Y. A collaborative study in Japan on optimal treatment period and parameters for detection of male fertility disorders induced by drugs in rats. Journal of the American College of Toxicology. 14:1995;266-292.
20. Yamada T., Maita K., Makamura J., Murakami M., Okuno Y., Hosokawa S., Matsuo M., Yamada H. Carcinogenicity studies of oxolinic acid in rats and mice. Food and Chemical Toxicology. 32:1994;397-408.
21. Yamada T., Nakamura J., Murakami M., Okuno Y., Hosokawa S., Matsuo M., Yamada H. The correlation of serum lutenizing levels with the induction of Leydig cell tumors in rats by oxolinic acid. Toxicology and Applied Pharmacology. 129:1994;146-154.
22. Yamada T., Nakayama J., Murakami M., Okuno K., Hosokawa S., Matsuo M., Yamada H. Effect of chronic L-DOPA administration on serum luteinizing hormone levels in male rats. Toxicology. 97:1995;173-182.
23. Yamada T., Nakamura J., Okuno Y., Hosokawa S., Matsuo M., Yamada H., Ohta M. A possible mechanism for the increase in serum luteinizing hormone levels in male rats by oxolinic acid. Toxicology and Applied Pharmacology. 134:1995;35-42.