Placebo-controlled, double-blind, randomized study of prophylactic antibiotics in elective abdominal hysterectomy

Journal of Hospital Infection

Volumn 52, Issue 4, 2002, Pages 302-306

  Chongsomchai, Chompilas ^a   Lumbiganon, P ^a   Thinkhamrop, J ^a   Ounchai, J ^b   Vudhikamraksa, N ^b  

^a KHON KAEN UNIVERSITY   (Thailand)

^b KHON KAEN HOSPITAL   (Thailand)

Author keywords

Abdominal hysterectomy; Antibiotic prophylaxis

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CEFAZOLIN; PLACEBO; WATER; ANTIINFECTIVE AGENT; PENICILLIN DERIVATIVE;

ABDOMINAL HYSTERECTOMY; ADULT; ANTIBIOTIC PROPHYLAXIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ELECTIVE SURGERY; FEMALE; FEVER; HOSPITAL DISCHARGE; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MORBIDITY; MULTICENTER STUDY; POSTOPERATIVE INFECTION; POSTOPERATIVE PERIOD; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; SURGICAL INFECTION; THAILAND; TREATMENT OUTCOME; URINARY TRACT INFECTION; VAGINITIS; COMPARATIVE STUDY; FOLLOW UP; HYSTERECTOMY; INCIDENCE; INFECTION CONTROL; METHODOLOGY; POSTOPERATIVE COMPLICATION; RANDOMIZED CONTROLLED TRIAL; STANDARD; STATISTICAL MODEL;

ADULT; AMPICILLIN; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; CEFAZOLIN; DOUBLE-BLIND METHOD; FEMALE; FEVER; FOLLOW-UP STUDIES; HUMANS; HYSTERECTOMY; INCIDENCE; INFECTION; INFECTION CONTROL; LOGISTIC MODELS; MORBIDITY; PENICILLINS; PLACEBOS; POSTOPERATIVE COMPLICATIONS; SURGICAL PROCEDURES, ELECTIVE; THAILAND;

EID: 0036887261     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhin.2002.1312     Document Type: Article

References (23)

1. Dicker, RC, Greenspan, JR, Strauss, LT et al. (1982). Complications of abdominal and vaginal hysterectomy among women of reproductive age in the United States. Am J Obstet Gynecol, 144 841-884.
2. Hemsell, DL, Reisch, J, Nobles, B, Hemsell, PG (1983). Prevention of major infection after elective abdominal hysterectomy: individual determination required. Am J Obstet Gynecol, 147 520-528.
3. Tanos, V, Rojansky, N (1994). Prophylactic antibiotics in abdominal hysterectomy. J Am Coll Surg, 179 593-600.
4. Pothinam, S, Sirinavasatian, P, Lumbiganon, P (1992). Febrile and infectious morbidity after abdominal hysterectomy at Srinagarind Hospital. J Med Assoc Thai, 75 178-182.
5. Duff, P (1982). Antibiotic prophylaxis for abdominal hysterectomy. Obstet Gynecol, 60 25-29.
6. Schwarz, RH (1982). Postoperative infection. In GR G Monif (Ed.), Infectious Diseases in Obstetrics and Gynecology. 2nd edn, 601-604. Philadelphia: Harper & Row Publishers.
7. Mead, PB (1981). Abdominal wound infections. In G Schaefer, EA Graber (Eds.), Complications in Obstetrics and Gynecologic Surgery. Prevention, Diagnosis and Treatment, 130-139. Hagerstown: Harper & Row Publishers.
8. Shapiro, M, Munoz, A, Tager, IB, Schoenbaum, SC, Polk, BF (1982). Risk factors for infection at the operative site after abdominal or vaginal hysterectomy. N Engl J Med, 307 1611-1616.
9. Grossman, III JH, Greceo, TP, Minkin, MJ, Adams, RL, Hierholzer, Jr. WJ, Andriole, VT (1979). Prophylactic antibiotics in gynecologic surgery. Obstet Gynecol, 53 537-544.
10. Lwanga, SK, Lemeshow, S (1991). Sample size determination in health studies. A practical manual. Geneva: World Health Organization.
11. Polk, BF, Shapiro, M, Goldstein, P, Tager, IB, Goren-White, B, Schoenbaum, SC (1980). Randomised clinical trial of perioperative cefazolin in preventing infection after hysterectomy. Lancet, 1 437-441.
12. Faro, S (1988). Prevention of infections after obstetric and genecologic surgery. J Reprod Med, 33 154-158.
13. Houang, TE (1991). Antibiotic prophylaxis is hysterectomy and induced abortion. A review of the evidence. Drugs, 41 19-37.
14. Shapiro, M, Schoebaum, SC, Tager, IB, Munoz, A, Polk, BF (1983). Benefit-cost analysis of antimicrobial prophylaxis in abdominal and vaginal hysterectomy. J Am Med Assoc, 249 1290-1294.
15. Dicker, RC, Greenpan, JR, Strauss, LT et al. (1984). Complications of abdominal and vaginal hysterectomy among women of reproductive age in the United States. Am J Obstet Gynecol, 91 73-77.
16. Holman, JF, McGowan, JE, Thompson, JD (1978). Peri-operative antibiotics in major elective gynecologic surgery. South Med J, 71 417-421.
17. Hemsell, DL, Edward, RJ, Hemsell, PG, Nobles, BJ, Heard, MC (1990). Cefazolin for hysterectomy prophylaxis. Obstet Gynecol, 76 603-606.
18. Mathews, DD, Agarwal, V, Ross, H (1978). A randomized controlled trial of a short course of cephaloridine in the prevention of infection after abdominal hysterectomy. Br J Obstet Gynaecol, 85 381-385.
19. Itskovitz, J, Fisher, M, Urbach, J, Brandes, MJ (1980). The effect of short-term course of antibiotic prophylaxis on patients undergoing total abdominal hysterectomy. Eur J Obstet Gynecol Reprod Biol, 11 101-107.
20. Stage, HA, Glover, DD, Vaughan, EJ (1982). Low-dose cephradine prophylaxis in obstetric and gynecologic surgery. J Reprod Med, 27 113-119.
21. Berkeley, AS, Hayworth, SD, Hirsch, JC, Freedman, KS, Ledger, WJ (1985). Controlled, comparative study of moxalactam and cefazolin for prophylaxis of abdominal hysterectomy. Surg Gynecol Obstet, 161 457-461.
22. Gonen, R, Hakim, M, Samberg, I, Levitan, Z, Sharf, M (1985). Short-term prophylactic antibiotic for elective abdominal hysterectomy; how short?. Eur J Obstet Gynecol Reprod Biol, 20 229-234.
23. Hakim, M, Gonen, R, Levitan, Z, Sharf, M (1986). Broad-spectrum antibiotics as short-term prophylaxis for elective abdominal hysterectomy; comparison of mezlocillin, cefazolin and placebo. Int J Gynaecol Obstet, 24 157-160.