Antioxidant and Cytotoxic Activities of Hypericum sp. on Brine Shrimps and Human Cancer Cell Lines

Phytotherapy Research

Volumn 16, Issue 8, 2002, Pages 719-722

  Couladis, M ^a   Badisa, R B ^a,b   Baziou, P ^a,b   Chaudhuri, S K ^a   Pilarinou, E ^a,b   Verykokidou, E ^a   Harvala, C ^a,b  

^a UNIVERSITY OF ATHENS   (Greece)

^b WaIkcr Cancer Research Institute   (United States)

Author keywords

Antioxidant activity; Brine shrimps; Caco 2 cells; Cytotoxicity; Hepg2 cells; Hypericum sp

Indexed keywords

ANTIOXIDANT; PLANT EXTRACT;

ANIMAL; ARTEMIA; ARTICLE; CELL CULTURE; CELL STRAIN CACO 2; COLON TUMOR; DRUG EFFECT; HUMAN; HYPERICUM; LD 50; LIVER CELL CARCINOMA; PHYTOTHERAPY;

ANIMALS; ANTIOXIDANTS; ARTEMIA; CACO-2 CELLS; CARCINOMA, HEPATOCELLULAR; COLONIC NEOPLASMS; HUMANS; HYPERICUM; LETHAL DOSE 50; PHYTOTHERAPY; PLANT EXTRACTS; TUMOR CELLS, CULTURED;

EID: 0036885953     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1042     Document Type: Article

References (18)

1. Anderson JE, Goetz CM, McLaughlin JL 1991. A blind comparison of simple bench-top bioassays and human tumor cell cytotoxicities as antitumor prescreens. Phytochem Analy 2: 107-111.
2. Badisa RB, Chaudhuri SK, Pilarinou E et al. 2000. Licania michauxii prance root extract induces hsp 70 mRNA and necrotic cell death in cultured human hepatoma and colon carcinoma cell lines. Cancer Lett 149: 61-68.
3. Blumenthal M. 1998. The Complete German Commission E Monographs. American Botanical Council: Austin TX; 214.
4. Couladis M, Tsoctanidou V, Francisco-Ortega J et al. 2000. Antioxidant activity of Argyranthemum spp. aerial parts. Pharmac Biol 39: 54-56.
5. Ekimoto H, Takahashi K, Matsuda A, Takita T, Umezawa H. 1985. Lipid peroxidation by bleomycin-iron complexes in vitro. J Antibiotics 38: 1077-1082.
6. Ferdous AJ, Stembridge NY, Singh M. 1998. Role of monensin PLGA polymer nanoparticles and liposomes as potentiator of ricin A immunotoxins in vitro. J Controlled Release 50: 71-78.
7. Harrer G, Schulz V. 1994. Clinical investigation of the antidepressant effectiveness of hypericin. J Geriatr Psychiatr Neuron (Suppl. 1): 6-8.
8. Ishiguro K, Yamaki M, Kashihara M, Takagi S, Isoi K, Sarothralin G. 1990. A new antimicrobial compound from Hypericum japonicum. Planta Med 56: 274-276.
9. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D. 1996. St John's Wort for depression-an overview and meta-analysis of randomized clinical trials. Br Med J 313: 253-258.
10. Mantle D, Eddeb F, Pickering AT. 2000. Comparison of relative antioxidant activities of British medicinal plant species in vitro. J Ethnopharmacol72: 47,-51.
11. McLaughlin JL. 1991. The brine shrimp lethality bioassay. In Methods in Plant Biochemistry, vol. 6, Hostettmann K (ed.). Academic Press: London, 8-10.
12. Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DE, McLaughlin JL. 1982. Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med45: SI34.
13. Newall CA, Anderson LA, Philipson JD. 1996. Herbal Medicines, A Guide for Health-care Professionals. The Pharmaceutical Press: London, 250-252.
14. Rosha L, Marston A, Porterai O et al. 1995. Antibacterial phloroglucinols and flavonoids from Hypericum brasiliense. Phytochemistry 40: 1447-1452.
15. Volz HP. 1997. Controlled clinical trials of Hypericum extracts in depressed patients-an overview. Pharmacopsychiaf/y30(Supp!2):72-76.
16. Vorbach EU, Arnoldt KH, Hubner WH. 1997. Efficacy and tolerability of St. John's Wort extract LI 160 versus imipramine in patients with severe depressive episodes according to ICD-10. Pharmacopsychiatry 30 (Suppl 2): 81-85.
17. WheatlyD. 1997. L1160, an extract of St. John's Wort, versus amitriptyline in mildly to moderately depressed outpatients-a controlled 6 week clinical trial. Pharmacopsychiatry 30 (Suppl 2): 77-80.
18. Yip L, Hudson JB, Gruszecka-Kowalik E, Zalkow LH, Neil Towers GH. 1996. Antiviral activity of a derivative of the photosensitive compound hypericin. Phytomedicine III: 185-190.