The effect of a SCN -/H 2O 2 toothpaste compared to a commercially available triclosan-containing toothpaste on oral hygiene and gingival health - A 6-month home-use study

Journal of Clinical Periodontology

Volumn 29, Issue 12, 2002, Pages 1086-1091

  Rosin, Michael ^a,c,d   Kramer, Axel ^b   Bradtke, Detlef ^a   Richter, Gerrit ^a   Kocher, Thomas ^c  

^a Department of Operative Dentistry Periodontology and Paediatric Dentistry ^*

^b Institute of Hygiene and Environmental Medicine   (Germany)

^c UNIVERSITY OF GREIFSWALD   (Germany)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Carbamide peroxide; Gingivitis; Thiocyanate; Toothpaste

Indexed keywords

COLGATE TOTAL; DRUG DERIVATIVE; FLUORIDE; PEROXIDE; THIOCYANATE POTASSIUM; THIOCYANIC ACID DERIVATIVE; TOOTHPASTE; TOPICAL ANTIINFECTIVE AGENT; TRICLOSAN; UREA; UREA PEROXIDE;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG MIXTURE; FEMALE; GINGIVITIS; HUMAN; MALE; METHODOLOGY; MOUTH HYGIENE; MULTICENTER STUDY; OBSERVER VARIATION; PERIODONTICS; RANDOMIZED CONTROLLED TRIAL; REPRODUCIBILITY; TOOTH PLAQUE;

ADULT; ANALYSIS OF VARIANCE; ANTI-INFECTIVE AGENTS, LOCAL; COMPLEX MIXTURES; DENTAL PLAQUE; DENTAL PLAQUE INDEX; DENTIFRICES; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; FLUORIDES; GINGIVITIS; HUMANS; MALE; OBSERVER VARIATION; ORAL HYGIENE; PERIODONTAL INDEX; PEROXIDES; REPRODUCIBILITY OF RESULTS; THIOCYANATES; TOOTHPASTE; TRICLOSAN; UREA;

EID: 0036885776     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-051X.2002.291207.x     Document Type: Article

References (41)

1. Addy, M., Moran, J., Wade, W. & Jenkins, S. (1992) The evaluation of toothpaste products in promoting gingival health. In: Embury, G. & Rolla, G. (eds): Clinical and biological aspects of dentifrices, pp. 249-269. Oxford: Oxford Medical Publications.
2. Apitzsch, L., Kramer, A., Mueller, B., Sinnecker, R., Grimm, U., Schroeder, H. & Weuffen, W. (1985) Untersuchungen zur Beeinflussung der Antikörperbildung durch Thiocyanat bei Tollwutschutzimpfung mit Zellkulturimpfstoff (UdSSR). Zeitschrift für Klinische Medizin 40, 1705-1707.
3. Attström, R. & van der Velden, U. (1994) Consensus report of session I. In: Lang, N. P. & Karring, R. (eds) Proceedings of the 1st European Workshop on Periodontology, pp. 120-126. London: Quintessence Publishing Co.
4. Barkvoll, P. & Rölla, G. (1994) Triclosan protects the skin against dermatitis caused by sodium lauryl sulphate exposure. Journal of Clinical Periodontology 21, 717-719.
5. Binney, A., Addy, M., McKeown, S. & Everatt, L. (1995) The effect of a commercially available triclosan-containing toothpaste compared to a sodium-fluoride-containing toothpaste and a chlorhexidine rinse on 4-day plaque regrowth. Journal of Clinical Periodontology 22, 830-834.
6. Binney, A., Addy, M., Owens, J., Faulkner, J., McKeown, S. & Everatt, L. (1996) A 3-month home use study comparing the oral hygiene and gingival health benefits of triclosan and conventional fluoride toothpastes. Journal of Clinical Periodontology 23, 1020-1024.
7. Bolden, T. E., Zambon, J. J., Sowinski, J., Ayad, F., McCool, J. J., Volpe, A. R. & De-Vizio, W. (1992) The clinical effect of a dentifrice containing triclosan and a copolymer in a sodium fluoride/silica base on plaque formation and gingivitis; a 6 month clinical study. Journal of Clinical Dentistry 3, 125-131.
8. Gaffar, A., Scherl, D., Afflitto, J. & Coleman, E. J. (1995) The effect of triclosan on mediators of gingival inflammation. Journal of Clinical Periodontology 22, 480-484.
9. Garcia-Godoy, F., Garcia-Godoy, F., DeVizio, W., Volpe. A., Ferlauto, R. J. & Miller, J. M. (1990) Effect of a triclosan copolymer fluoride dentifrice on plaque formation and gingivitis: a 7-month clinical study. American Journal of Dentistry 3, 515-526.
10. Jeffcoat, M. K. (1994) Prevention of periodontal diseases in adults: strategies for the future. Preventive Medicine 23, 704-708.
11. Jülich, W. D., Weuffen, W., Bohnenstengel, C. & Klatt, W. (1973) Immunregulatorische Effektivität des Methenaminhydrorhodanids (Rhodovet). Allergie und Immunologie 19, 173-177.
12. Jülich, W. D., Kramer, A., Hingst, V., Sonntag, H. G., Schutt, C., Daut, M., Schulz, A., Bahlmann, G., Zöllner, H., Hampel, R. & Panzig, E. (1997) Alimentäre Thiocyanatsupplementierung bei der Hepatitis-B- Schutzimpfung: Stimulierung der Immunantwort - Untersuchungen bei gesunden Probanden und bei Dialysepatienten. Umweltmedizin in Forschung und Praxis 2, 71-82.
13. Kjaerheim, V., Barkvoll, P., Waaler, S. M. & Rolla, G. (1995) Triclosan inhibits histamine-induced inflammation in human skin. Journal of Clinical Periodontology 22, 423-426.
14. Koch, S. (1989) Tierexperimentelle Untersuchungen zum Einfluß von Thiocyanaten auf ausgewählte Regenerationsprozesse im Sä ugetierorganismus. Thesis. Greifswald: Greifswald University.
15. Kocher, T., Sawaf, H., Warncke, M. & Welk, A. (2000) Resolution of interdental inflammation with 2 different modes of plaque control. Journal of Clinical Periodontology 27, 883-888.
16. Kramer, A. (1985) Prüfsystem zur Erfassung der Verträglichkeit antimikrobiell wirksamer Stoffe und Zubereitungen zur episomatischen Applikation durch in-vitro und tierexperimentelle Tests (Episomatiktest) und die toxikologische Bewertung als Bestandteil krankenhaushygienischer Aufgabenstellungen. Thesis, Greifswald: Greifswald University.
17. Kramer, A. & Böhland, H. (1996) Biological, medical and chemical aspects of thiocyanate research. Hygiene und Medizin 21, 335-345.
18. Kramer, A. & Weuffen, R. (1996) Antiphlogistic effect of thiocyanate at the chorioallantois membrane of the hen egg and the eye of the guinea pig. Experimental Eye Research 63 (Suppl. 1), 148.
19. Kramer, A., Weuffen, W., Minnich, S., Koch, S., Minnich, M., Below, H., Thürkow, B. & Meffert, H. (1990) Förderung der Haarentwicklung durch Thiocyanat beim Meerschweinchen. Dermatologische Monatsschrift 176, 417-420.
20. Löe, H., Anerud, A., Boysen, A. & Morrison, E. (1986) Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan labourers 14-46-years of age. Journal of Clinical Periodontology 13, 431-440.
21. Löe, H. & Silness, J. (1963) Periodontal disease in pregnancy (I). Prevalence and severity. Acta Odontologica Scandinavica 21, 533-551.
22. Modéer, T., Bengtsson, A. & Rolla, G. (1996) Triclosan reduces prostaglandin biosynthesis in human gingival fibroblasts challenged with interleukin-1 in vitro. Journal of Clinical Periodontology 23, 927-933.
23. Mustafa, M., Wondimu, B., Ibrahim, M. & Modéer, T. (1998) Effect of triclosan on interleukin-1β produktion in human gingival fibroblasts challenged with tumor necrosis factor α. European Journal of Oral Sciences 106, 637-643.
24. Mustafa, M., Bakhiet, M., Wondimu, B. & Modéer, T. (2000) Effect of triclosan on interferon γ production and major histocompatibility complex class expression in human gingival fibroblasts. Journal of Clinical Periodontology 27, 733-737.
25. Nagasawa, H., Yanai, R., Nakajima, Y., Namiki, H., Kikuyama, S. & Shiota, K. (1980) Inhibitory effects of potassium thiocyanate on normal and neoplastic mammary development in female mice. European Journal of Cancer 16, 473-480.
26. Owens, J., Addy, M. & Faulkner, J. (1997) An 18-week home-use study comparing the oral hygiene and gingival health benefits of triclosan and conventional fluoride toothpastes. Journal of Clinical Periodontology 24, 626-631.
27. Pollock, J. J., Goodman, H., Elsey, P. K. & Iacono, V. J. (1983) Synergism of lysozyme, proteases and inorganic monovalent anions in the bacteriolysis of oral Streptococcus mutans GS5. Archives of Oral Biology 28, 865-873.
28. Pruitt, K. M., Tenovuo, J., Fleming, W. & Adamson, M. (1982) Limiting factors for the generation of hypothiocyanite ion, an antimicrobial agent, in human saliva. Caries Research 16, 315-323.
29. Quigley, G. A. & Hein, J. W. (1962) Comparative cleansing efficiency of manual and power brushing. Journal of American Dental Association 65, 26-29.
30. Ramberg, P., Furuichi, Y., Sherl, D., Volpe, A. R., Nabi, N., Gaffar, A. & Lindhe, J. (1995) The effect of triclosan on developing gingivitis. Journal of Clinical Periodontology 22, 442-448.
31. Robinson, P. J. (1995) Gingivitis: a prelude to periodontitis. Journal of Clinical Dentistry 6, 41-45.
32. 2 combinations in dentifrices on plaque and gingivitis. Journal of Clinical Periodontology 28, 270-276.
33. Rosling, B., Wannfors, B., Volpe, A. R., Furuichi, Y., Ramberg, P. & Lindhe, J. (1997) The use of triclosan/copolymer dentifrice may retard progression of periodontitis. Journal of Clinical Periodontology 24, 873-880.
34. Sheiham, A. (1997) Is the chemical prevention of gingivitis necessary to prevent severe periodontitis. Periodontology 2000 15, 15-24.
35. Svatun, B., Saxton, C. A., Huntington, E. & Cummins, D. (1993) The effects of three silica dentifrices containing triclosan on supragingival plaque and on gingivitis. International Dental Journal 43, 441-452.
36. Talbot, K., Mandel, I. & Chilton, N. W. (1977) Reduction of baseline gingivitis scores with repeated prophylaxis. Journal of Preventive Dentistry 4, 28-29.
37. Tenovuo, J. & Pruitt, K. M. (1984) Relationship of the human salivary peroxidase system to oral health. Journal of Oral Pathology 13, 573-584.
38. Turesky, S., Gilmore, N. D. & Glickman, I. (1970) Reduced plaque formation by the chlormethyl analogue of vitamine C. Journal of Periodontology 41, 41-43.
39. Waaler, S. M., Rolla, G., Skjörland, K. K. & Ögaard, B. (1993) Effect of oral rinsing with triclosan and sodium lauryl sulphate on dental plaque formation: a pilot study. Scandinavian Journal of Dental Research 101, 192-195.
40. Whitehouse, M. W. & Rainsford, K. D. (1983) Prevention of the gastrotoxicity of aspirin and related drugs in rats by lithium salts and sodium thiocyanate. Toxicological Applications in Pharmacology 68, 323-327.
41. Wohlrab, W. (1989) Bedeutung von Harnstoff in der externen Therapie. Hautarzt 40 (Suppl. 9), 35-40.