Cu2+ suppresses GABAA receptor-mediated responses in rat sacral dorsal commissural neurons

NeuroSignals

Volumn 11, Issue 6, 2002, Pages 322-328

  Zhu, Hai Lei ^a   Wang, Dian Shi ^a   Li, Ji Shuo ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Copper; GABAA receptor; Patch clamp; Rat; Sacral dorsal commissural nucleus; Zinc

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; COPPER ION; NYSTATIN; 4 AMINOBUTYRIC ACID; COPPER; ZINC;

ANIMAL CELL; ARTICLE; BRAIN COMMISSURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GABAERGIC SYSTEM; MAMMAL; NERVE CELL; NONHUMAN; PERFORATION; RAT; REDUCTION; SYNAPTIC TRANSMISSION; ANIMAL; CELL CULTURE; CELL MEMBRANE POTENTIAL; DOSE RESPONSE; DRUG EFFECT; METABOLISM; NERVE CELL INHIBITION; NEWBORN; PHYSIOLOGY; POSTERIOR HORN CELL; SACRUM; SPRAGUE DAWLEY RAT; SYNAPSE;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; MEMBRANE POTENTIALS; NEURAL INHIBITION; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SACRUM; SYNAPSES; SYNAPTIC TRANSMISSION; ZINC;

EID: 0036877079     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068254     Document Type: Article

References (30)

1. Hui K, Davis BA, Boulton AA: Analysis of copper in brain by the masspectromeric-integrated-ion-current procedure. Neurochem Res 1977;2:495-506.
2. Wong PY, Fritze K: Determination by neutron activation of copper, manganese, and zinc in the pineal body and other areas of brain tissue. J Neurochem 1969;16:1231-1234.
3. 2+ in rat brain regions. Can J Biochem 1973;51:87-92.
4. Kozma M, Szerdahelyi P, Kása P: Histochemical detection of zinc and copper in various neurons of the central nervous system. Acta Histochem 1981;69:12-17.
5. Kreuder J, Otten A, Fuder H, Tümer Z, Tonnesen T, Horn N, Dralle D: Clinical and biochemical consequences of copper-histidine therapy in Menkes disease. Eur J Pediatr 1993;152:828-832.
6. Brewer GJ, Yuzbasiyan-Gurkan V: Wilson's disease. Medicine (Baltimore) 1992;71:139-164.
7. Rajan KS, Colburn RW, Davis JM: Distribution of metal ions in the subcellular fractions of several brain areas. Life Sci 1976;18:423-431.
8. Kardos J, Kovacs I, Hajos F, Kalman M, Simonyi M: Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability. Neurosci Lett 1989;103:139-144.
9. 67 copper. Synapse 1988;2:412-415.
10. Weiser T, Wienrich M: The effects of copper ions on glutamate receptors in cultured rat cortical neurons. Brain Res 1996;742:211-218.
11. Vlachová V, Zemková H, Vyklický L Jr: Copper modulation of NMDA responses in mouse and rat cultured hippocampal neurons. Eur J Neurosci 1996;8:2257-2264.
12. 2+ potently enhances ATP-activated current in rat nodose ganglion neurons. Neurosci Lett 1996;219:45-48.
13. Yakushiji T, Tokutomi N, Akaike N, Carpenter DO: Antagonists of GABA responses, studied using internally perfused frog dorsal root ganglion neurons. Neuroscience 1987;22:1123-1133.
14. A receptor-channel complex by polyvalent cations in rat dorsal root ganglion neurons. Brain Res 1993;607:222-232.
15. Trombley PQ, Shepherd GM: Differential modulation by zinc and copper of amino acid receptors from rat olfactory bulb neurons. J Neurophysiol 1996;76:2536-2546.
16. A receptor-mediated currents in acutely isolated cerebellar Purkinje cells of the rat. Eur J Neurosci 1998;10:522-528.
17. Lu Y, Inokuchi H, McLachlan EM, Li JS, Higashi H: Correlation between electrophysiology and morphology of three groups of neurons in the dorsal commissural nucleus of lumbosacral spinal cord of mature rats studied in vitro. J Comp Neurol 2001;437:156-169.
18. Xu TL, Dong XP, Wang DS: N-methyl-D-aspartate enhancement of the glycine response in the rat sacral dorsal commissural neurons. Eur J Neurosci 2000;12:1647-1653.
19. Akaike N, Harata N: Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Jpn J Physiol 1994;44:433-473.
20. A receptor mediated responses in)acutely dissociated sacral dorsal commissural neurons. Sheng Li Xue Bao 1998;50:649-655.
21. Akaike N, Yakushiji T, Tokutomi N, Carpenter DO: Multiple mechanisms of antagonism of γ-aminobutyric acid (GABA) responses. Cell Mol Neurobiol 1987;7:97-103.
22. Celentano JJ, Gyenes M, Gibbs TT, Farb DH: Negative modulation of the γ-aminobutyric acid response by extracellular zinc. Mol Pharmacol 1991;40:766-773.
23. 2+ in cerebellar granule cells in culture. Eur J Neu-rosci 1993;5:65-72.
24. Telgkamp P, Backus KH, Deitmer JW: Blockade of AMPA receptors by nickel in cultured rat astrocytes. Glia 1996;16:140-146.
25. 3 receptor-mediated ion currents by divalent metal cations in NCB-20 neuroblastoma cells. J Neurophysiol 1991;66:1329-1337.
26. Hille B: The receptor for tetrodotoxin and saxitoxin. A structural hypothesis. Biophys J 1975;15:615-619.
27. Narahashi T, Anderson NC, Moore JW: Comparison of tetrodotoxin and procaine in internally perfused squid giant axons. J Gen Physiol 1967;50:1413-1428.
28. Sieghart W: Structure and pharmacology of γ-aminobutyric acid A receptor subtypes. Pharmacol Rev 1995;47:182-234.
29. A receptors in acutely isolated cerebellar Purkinje cells of the rat. Br J Pharmacol 2000;130:851-856.
30. A response in the rat sacral dorsal commissural neurones. Br J Pharmacol 1998;124:779-787.