In vitro antiangiogenic effect of Sandostatin (octreotide) on the proliferation of the placental vessels

Anticancer Research

Volumn 22, Issue 6 C, 2002, Pages 4225-4227

  Zalatnai, Attila ^a   Timár, Ferenc ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Angiogenesis; In vitro; Octreotide

Indexed keywords

ANGIOGENESIS INHIBITOR; FIBRIN; OCTREOTIDE;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CAPILLARY PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MICROVASCULATURE; PLACENTA; PRIORITY JOURNAL;

ANGIOGENESIS INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; OCTREOTIDE; PLACENTA;

EID: 0036875344     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Pollak MN and Schally AV: Mechanisms of antineoplastic action of somatostatin analogs. Minireview. Proc Soc Exp Biol Med 217: 143-152, 1998.
2. Denzler B and Reubi JC: Expression of somatostatin receptors in peritumoral veins of human tumors. Cancer 85: 188-198, 1999.
3. Reubi JC, Horisberger U and Laissue J: High density of somatostatin receptors in veins surrounding human cancer tissue: role in tumor-host interaction? Int J Cancer 56: 681-688, 1994.
4. Reubi JC, Mazzucchelli L and Laissure JA: Intestinal vessels express a high density of somatostatin receptors in human inflammatory bowel disease. Gastroenterology 106: 951-959, 1994.
5. Parish CR, Freeman C, Brown KJ, Francis DJ and Cowden WB: Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity. Cancer Res 59: 3433-3441, 1991.
6. Danesi R and Del Tacca M: The effects of the somatostatin analog octreotide on angiogenesis in vitro. Metabolism 45 (Suppl 1): 49-50, 1996.
7. Danesi R, Agen C, Benelli U, Paolo AD, Nardini D, Bocci G et al: Inhibition of experimental angiogenesis by the somatostatin analogue octreotide acetate (SMS 201-995). Clin Cancer Res 3: 265-272, 1997.
8. Lawnicka H, Stepien H, Wyczolkowska J, Kolago B, Kunert-Radek J and Komorowski J: Effect of somatostatin and octreotide on proliferation and vascular endothelial growth factor secretion from murine endothelial cell line (HECa10) culture. Biochem Biophys Res Commun 268: 567-571, 2000.
9. Barrie R, Woltering EA, Hajarizadeh H, Mueller C, Ure T and Fletcher WS: Inhibition of angiogenesis by somatostatin and somatostatin-like compounds is structurally dependent. J Surg Res 55: 446-450, 1993.
10. Dasgupta P and Mukherjee R: Lipophilization of somatostatin analog RC-160 with long chain fatty acid improves its antiproliferative and antiangiogenic activity in vitro. Br J Pharmacol 129: 101-109, 2000.
11. Gulec SA, Drouant GJ, Fuselier J, Anthony CT, Heneghan J, DelCarpio JB et al: Antitumor and antiangiogenic effects of somatostatin receptor-targeted in situ radiation with (111)ln-DTPA-JIC 2DL. J Surg Res 97: 131-137, 2001.
12. Patel PC, Barrie R, Hill N, Landeck S, Kurozawa D and Woltering EA: Postreceptor signal transduction mechanisms involved in octreotide-induced inhibition of angiogenesis. Surgery 116: 1148-1152, 1994.
13. Mentlein R, Eichler O, Forstreuter F and Held-Feindt J: Somatostatin inhibits the production of vascular endothelial growth factor in human glioma cells. Int J Cancer 92: 545-560, 2001.
14. Cascinu S, Del Ferro E, Ligi M, Staccioli MP, Giordani P, Catalano V et al: Inhibition of vascular endothelial growth factor by octreotide in colorectal cancer patients. Cancer Invest 19: 8-12, 2001.
15. Averbukh E, Halpert M, Yanko R, Yanko L, Peer J, Levinger S et al: Octreotide, a somatostatin analogue, fails to inhibit hypoxia-induced retinal neovascularization in the neonatal rat. Int J Exp Diabetes Res 1: 39-47, 2000.
16. Vidal S, Kovacs K, Horvath E, Scheithauer BW, Kuroki T and Lloyd RV: Microvessel density in pituitary adenomas and carcinomas. Virchows Arch 438: 595-602, 2001.