Safety and feasibility of cardiac FDG SPECT following oral administration of acipimox, a nicotinic acid derivative: Comparison of image quality with hyperinsulinemic euglycemic clamping in nondiabetic patients

Journal of Nuclear Cardiology

Volumn 9, Issue 6, 2002, Pages 587-593

  Bax, Jeroen J ^a   Visser, Frans C ^b   Poldermans, Don ^c   van Lingen, Arthur ^b   Elhendy, Abdou ^c   Boersma, Eric ^c   Sloof, Gerrit W ^b   Visser, Cees A ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Fluorine 18 deoxyglucose; Image quality; Myocardial viability

Indexed keywords

ACIPIMOX; FATTY ACID; FLUORODEOXYGLUCOSE F 18; GLUCOSE; INSULIN; NICOTINIC ACID DERIVATIVE;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SAFETY; FATTY ACID BLOOD LEVEL; FEASIBILITY STUDY; FEMALE; FLUSHING; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HEART DISEASE; HEART MUSCLE; HUMAN; HYPERINSULINEMIA; IMAGE QUALITY; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIOLOGICAL PARAMETERS; SIDE EFFECT; SINGLE DRUG DOSE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 0036869906     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1067/mnc.2002.125391     Document Type: Article

References (21)

1. Beller GA. Non-invasive assessment of myocardial viability. N Engl J Med 2000;343:1488-90.
2. Bonow RO. Identification of viable myocardium. Circulation 1996;94:2674-80.
3. Bax JJ, Poldermans D, Elhendy A, Boersma E, Rahimtoola SH. Sensitivity, specificity, and predictive accuracies of various noninvasive techniques for detecting hibernating myocardium. Curr Prob Cardiol 2001;26:143-86.
4. Schelbert HR. Metabolic imaging to assess myocardial viability. J Nucl Med 1994;35(4 Suppl):8S-14S.
5. Gropler RJ. Methodology governing the assessment of myocardial glucose metabolism by positron emission tomography and fluorine 18-labeled fluorodeoxyglucose. J Nucl Cardiol 1994;1(2 Pt 2):S4-S14.
6. Knuuti J, Nuutila P, Ruotsalainen U, et al. Euglycemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial glucose utilization during positron emission tomography. J Nucl Med 1992;33:1255-62.
7. Knuuti MJ, Yki-Järvinen H, Voipi-Pulkki LM, et al. Enhancement of myocardial[fluorine-18] fluorodeoxyglucose uptake by a nicotinic acid derivative. J Nucl Med 1994;35:989-98.
8. Bax JJ, Veening MA, Visser FC, et al. Optimal metabolic conditions during fluorine-18 fluorodeoxyglucose imaging; A comparative study using different protocols. Eur J Nucl Med 1997;24:35-41.
9. 18F-fluorodeoxyglucose imaged with positron emission tomography and single photon emission computed tomography in dyssynergic myocardium. J Nucl Med 1996;37:1631-6.
10. Van Lingen A, Huijgens PC, Visser FC, et al. Performance characteristics of a 511-kev collimator for imaging positron emittors with a standard gamma camera. Eur J Nucl Med 1992;19:315-21.
11. Bax A Visser FC, Poldermans D, et al. Relationship between preoperative viability and postoperative improvement in LVEF and heart failure symptoms. J Nucl Med 2001;42:79-86.
12. Neely JR, Morgan HE. Relationship between carbohydrate and lipid metabolism and the energy balance of the heart muscle. Ann Rev Physiol 1974;36:412-59.
13. Vary TC, Reibel DK, Neely JR. Control of energy metabolism of heart muscle. Ann Rev Physiol 1981;43:419-30.
14. Camici P, Ferranini E, Opie LP. Myocardial metabolism in ischemic heart disease: Basic principles and application to imaging by positron emission tomography. Prog Cardiovasc Dis 1989;32:217-38.
15. Gropler RJ, Siegel BA. Lee KJ, et al. Nonuniformity in myocardial accumulation of fluorine-18-fluorodeoxyglucose in normal fasted humans. J Nucl Med 1990;31:1749-56.
16. Lee KS, Vom Dahl J, Hicks RJ, Schwaiger M. Relationship between blood glucose levels and F-18 fluorodeoxyglucose image quality in cardiac PET FDG studies [abstract]. J Am Coll Cardiol 1991;17:120A.
17. Vom Dahl J, Herman WH, Hicks RJ, et al. Myocardial glucose uptake in patients with insulin-dependent diabetes mellitus assessed quantitatively by dynamic positron emission tomography. Circulation 1993188:395-404.
18. Lewis P, Nunan T, Dynes A, Maisey M. The use of low-dose intravenous insulin in clinical myocardial F-18 FDG PET scanning. Clin Nucl Med 1996;21:15-8.
19. Martin WH, Jones RC, Delbeke D, Sandler MP. A simplified intravenous glucose loading protocol for fluorine-18 fluorodeoxyglucose cardiac single-photon emission tomography. Eur J Nucl Med 1997;24:1291-7.
20. Sandler MP, Bax JJ, Patton JA, Visser FC, Martin WH, Wijns W. Fluorine-18-fluorodeoxyglucose cardiac imaging using a modified scintillation camera. J Nucl Med 1998;39: 2035-43.
21. Musatti L, Maggi E, Moro E, et al. Bioavailability and pharmacokinetics of acipimox, a new antilipolytic and hypolipidaemic agent. J Int Med Res 1981;9:381-6.