Cellular and molecular aspects of drugs of the future: Meropenem

Cellular and Molecular Life Sciences

Volumn 59, Issue 11, 2002, Pages 1928-1933

  Cottagnoud, P ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Antimicrobial action; Mechanisms of resistance; Meropenem

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CARBAPENEM; IMIPENEM; MEROPENEM;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; BACTERIAL CELL WALL; BACTERIAL INFECTION; BACTERIAL MENINGITIS; BINDING AFFINITY; DIARRHEA; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG STRUCTURE; ENZYME ACTIVITY; EOSINOPHILIA; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; INFECTION; LIVER TOXICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NAUSEA; NONHUMAN; RASH; REVIEW; SEIZURE; THROMBOCYTOSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; BACTERIAL OUTER MEMBRANE PROTEINS; BETA-LACTAM RESISTANCE; FORECASTING; HUMANS; PROTEIN BINDING; THIENAMYCINS;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0036866048     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00012515     Document Type: Review

References (44)

1. Brown A. G., Corbett D. F., Eglington A. J. and Howarth T. T. (1979) Structures of olivanic acid derivatives MM 22380, MM 22381, MM 22382 and MM 22383: Four new antibiotics isolated from Streptomyces olivaceus. J. Antibiot. (Tokyo) 32: 961-963
2. Southgate R. and Elson S. (1985) Naturally occurring beta-lactams. Prog. Chem. Org. Nat. Prod. 47: 1-106
3. Coulton S. and Hunt E. (1996) Recent advances in the chemistry and biology of carbapenem antibiotics. Prog. Chem. Chem. 33: 99-145
4. Brown A. G., Butterworth D., Cole M., Hanscomb G., Hood J. D., Reading C. et al. (1976) Naturally occurring beta-lactamase inhibitors with antibacterial activity. J. Antibiot. 29: 668-669
5. Leanza W. J., Wildonger K. J., Miller T. W. and Christensen B. G. (1979) N-acetimidoyl- and N-formimidoyl thienamycin derivatives. J. Med. Chem. 22: 1435-1436
6. Armstrong D. J., Mukhopadhyay S. K. and Campbell B. J. (1974) Physicochemical characterization of renal peptidase. Biochemistry 13: 1745-1750
7. Norrby S. R., Alestig K., Bjornegard B., Burman L. A., Ferber F., Huber J. L. et al. (1983) Urinary recovery of N-formimidoyl thienamycin (MK0787) is affected by coadministration of N-formimidoyl thienamycin dehydropeptidase inhibitors. Antimicrob. Agents Chemother. 23: 300-307
8. Kahan F. M., Krop H., Sundelog G. H. and Birnbaum J. (1983) Thienamycin: Development of imipenem-cilastatin. J. Antimicrob. Chemother. 12 (suppl. D): 1-35
9. Neu H. C., Chin X. X., Saha G. and Labthavikul P. (1986) In vitro activity against aerobic and anaerobic Gram-positive bacteria and beta-lactamase stability of RS-533, a novel carbapenem. Antimicrob. Agents Chemother. 30: 828-834
10. Wise R. (1986) In vitro and pharmacokinetic properties of the carbapenems. Antimicrob. Agents Chemother. 30: 343-349
11. Ghuysen J. M. (1968) Use of bacteriolytic enzymes in determination of cell wall structure and their role in cell metabolism. Bacteriol. Rev. 32: 425-464
12. Schleiffer K. H. and Kandler O. (1972) Peptidoglycan types of bacterial cell walls and their taxonomic implications. Bacteriol. Rev. 36: 407-477
13. Tomasz A. and Fischer W. (2000) The cell wall of Streptococcus pneumoniae. In: Gram-Positive Pathogens, pp. 191-200, Fischetti V. et. al. (eds), American Society for Microbiology, Washington, D. C.
14. Garcia-Bustos J., Chait B. T. and Tomasz A. (1987) Structure of the peptide network of pneumococcal peptidoglycan. J. Biol. Chem. 262: 15400-15405
15. Hakenbeck R., Ellerbrok H., Martin C., Morelli G., Schuster G., Severin A. et al. (1993) Penicillin-binding protein 1A and 3 in Streptococcus pneumoniae: What are essential PBPs. In: Bacterial Growth and Iysis Metabolism and Structure of the Bacterial Sacculus, pp. 335-340, De Pedro M. A., Höltje J.-V. and Löffelhardt W. (eds), Plenum, New York
16. Hakenbeck R., Tornette S. and Adkinson N. F. (1987) Interaction of non-lytic β-lactams with penicillin-binding proteins in Streptococcus pneumoniae. J. Gen. Microbiol. 133: 754-760.
17. Georgopapadakou N. H. (1993) Penicillin-binding proteins and bacterial resistance to β-lactams. Antimicrob. Agents Chemother. 37: 2045-2053
18. Tomasz A. (1996) Penicillin-binding proteins and the antibacterial effectiveness of β-lactam antibiotics. J. Infect. Dis. 8 (suppl. 3): 260-278
19. Moellering R.C., Eliopoulos G.M. and Sentochnik D.E. (1989). The carbapenems: New broad spectrum β-lactam antibiotics. J. Antimicrob. Chemother. 24 (suppl. A): 1-7
20. Kitzis M. D., Acar J. F. and Gutmann L. (1989) Antibacterial activity of meropenem against Gram-negative bacteria with a permeability defect and against staphylococci. J. Antimicrob. Chemother. 24 (suppl. A):125-132
21. Nadler H. L., Pitkin D. H. and Scheikh W. (1989) The postantibiotic effect of meropenem and imipenem on selected bacteria. J. Antimicrob. Chemother. 24 (suppl. A): 225-231
22. Craig W. A. and Ebert S. C. (1991) Killing and regrowth of bacteria in vitro: A review. Scand. J. Infect. Dis. 74: 63-70
23. Dowson C. G., Hutchinson A., Brannigan R. C., George D., Hansman D., Linares J. et al. (1989) Horizontal transfer of penicillin-binding protein genes, in penicillin-resistant isolates of Streptococcus pneumoniae. Proc. Natl. Acad. Sci. USA 86: 8842-8846
24. Hakenbeck R., König A., Kern I., Linden M. van den, Keck W., Billot-Klein W. et al. (1998) Acquisition of five high-MW penicillin-binding protein variants during transfer of high-level β-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae. J. Bacteriol. 180: 1831-1840
25. Spratt B. G. (1994) Resistance to β-lactam antibiotics. In: Bacterial Cell Wall, pp. 517-534, Ghuysen M. and Hakenbeck R. (eds.), Elsevier, Amsterdam
26. Fontana R. (1985) Penicillin-binding proteins and the intrinsic resistance to beta-lactams in Gram-positive cocci. J. Antimicrob. Chemother. 16: 412-416
27. Fontana R., Cerini R., Longoni P., Grossato A. and Canepari P. (1983) Identification of a streptococcal penicillin-binding protein that reacts very slowly with penicillin. J. Bacteriol. 155: 1343-1350
28. Hartmann B. and Tomasz A. (1984) Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J. Bacteriol. 158: 513-516
29. Ubukata K., Yamashita N. and Konno M. (1985) Occurrence of a β-lactam inducible penicillin-binding protein in methicillin-resistant staphylococci. Antimicrob. Agents Chemother. 27: 851-857
30. Trias J. and Nikaido H. (1990) Protein D2 channel of Pseudomonas aeruginosa outer membrane has a binding site for basic amino acids and peptides. J. Biol. Chem. 265: 15680-15684.
31. Trias J. and Nikaido H. (1990) Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 34: 52-57
32. Livermore D. M. (1992) Interplay of impermeability and chromosomal β-lactamase in imipenem resistant Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 36: 2046-2048
33. Chen H. Y. and Livermore D. M. (1994) In-vitro activity of biapenem, compared with imipenem and meropenem, against Pseudomonas aeruginosa strains and mutants with known resistance mechanisms. J. Antimicrob. Chemother. 33: 949-958
34. Nikaido H. (1994) Prevention of drug access to bacterial targets: Permeability barriers and active efflux. Science 264: 382-388
35. Masuda N. and Ohya S. (1992) Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 36: 1847-1851
36. Li X.-Z., Ma D., Livermore D. M. and Nikaido H. (1994) Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: Active efflux as contributing factor to β-lactam resistance. Antimicrob. Agents Chemother. 38: 1742-1752
37. Livermore D. M. (1995) Bacterial resistance to carbapenems. In: Antimicrobial Resistance: A Crisis in Health Care, Jungking D. L. et al. (eds.), Plenum, New York
38. Fish D. N. and Singletary T. J. (1997) Meropenem, a new carbapenem antibiotic. Pharmacotherapy 17: 644-669
39. Watanabe M., Iyobe S., Inoue M. and Mitsuhashi S. (1991) Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 35: 147-151
40. Arakawa Y., Ito H., Oshuska S., Kato N. and Ohta M. (1994) Genetic analyses of an enterobacterial metallo-β-lactamase carried by a large plasmid of Serratia marcescens. In: Program and Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Abstr. C64, p. 89, American Society for Microbiology, Washington
41. Norrby S. R., Newell P. A., Faulkner K. L. and Lesky W. (1995) Safety profile of meropenem: International clinical experienced based on the first 3125 patients treated with meropenem. J. Antimicrob. Chemother. 36 (suppl. A): 207-223
42. Schliamser S. E., Cars O. and Norrby S. R. (1991) Neurotoxicity of beta-lactam antibiotics: Predisposing factors and pathogenesis. J. Antimicrob. Chemother. 27: 405-425
43. Hori S., Kanemitsu K. and Shimada J. (1999) Epileptogenic activity of meropenem, a new carbapenem: A comparative study of epileptogenic activity of carbapenems and β-lactams. In: Program and Abstracts of the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Calif; abstr. 301, p. 161
44. Frere J. M., Duez C., Ghuysen J. M., and Vandekerkhove J. (1976) Occurrence of a serine residue in the penicillin-binding site of the exocellular DD-carboxy-peptidase-transpeptidase from Streptomyces R61. FEBS Lett. 70: 257-260