Amoebapore is an important virulence factor of entamoeba histolytica

Journal of Biosciences

Volumn 27, Issue 6 SUPPL. 3, 2002, Pages 579-587

  Bracha, Rivka ^a   Nuchamowitz, Yael ^a   Mirelman, David ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Amoebapore; Entamoeba histolytica; Virulence factor

Indexed keywords

AMOEBAPORE A; COMPLEMENTARY RNA; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

VIRULENCE;

ARTICLE; CELL ULTRASTRUCTURE; CYTOSOL; ENTAMOEBA HISTOLYTICA; EPISOME; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENOME; NONHUMAN; PARASITE VIRULENCE; PLASMID; PROTOZOAL GENETICS; RNA TRANSLATION; TROPHOZOITE;

ENTAMOEBA HISTOLYTICA;

EID: 0036862066     PISSN: 02505991     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02704851     Document Type: Article

References (32)

1. Andersson M, Gunne H, Agerberth B, Boman A, Bergman T, Sillard R, Jornvall H, Mutt Y, Olsson B and Wigzell H 1995 NK-lysin, a novel effector peptide of cytotoxic T and NK-cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity; EMBO J. 14 1615-1625
2. Ankri S, Padilla-Vaca F, Stolarsky T, Koole L and Mirelman D 1999 Antisense inhibition of expression of the light subunit (35 kDa) of the Ga1/Ga1NAc lectin complex inhibits Entamoeba histolytica virulence; Mol. Microbiol. 33 327-337
3. Ankri S, Stolarsky T and Mirelman D 1998 Antisense inhibition of expression of cysteine proteinases in Entamoeba histolytica does not affect cytopathic or hemolytic activity but inhibits phagocytosis; Mol. Microbiol. 28 777-785
4. Berninghausen O and Leippe M 1997 Necrosis versus apoptosis as the mechanism of target cell death induced by Entamoeba histolytica; Infect. Immun. 65 3615-3621
5. Bracha R, Kobiler D and Mirelman D 1982 Attachment and ingestion of bacteria by trophozoites of Entamoeba histolytica; Infect. Immun. 36 396-406
6. Bracha R and Mirelman D 1984 Virulence of Entamoeba histolytica trophozoites: Effects of bacteria, microaerobic conditions, and Metronidazole; J. Exp. Med, 160 353-368
7. Bracha R, Nuchamowitz Y, Leippe M and Mirelman D 1999 Antisense inhibition of amoebapore expression in Entamoeba histolytica causes a decrease in amebic virulence; Mol. Microbiol. 34 463-472
8. Bracha R, Nuchamowitz Y and Mirelman D 2000 Inhibition of gene expression in Entamoeba by the transcription of antisense RNA: Effect of 5′ and 3′ regulatory elements; Mol. Biochem. Parasitol. 107 81-90
9. Bruhn H and Leippe M 2001 Novel putative saposin-like proteins from Entamoeba histolytica different from amoebapores; Biochim. Biophys. Acta 1514 14-20
10. Hamann L, Nickel R and Tannich E 1995 Transfection and continuous expression of heterologous genes in the protozoan parasite Entamoeba histolytica; Proc. Natl. Acad. Sci. USA 92 8975-8979
11. Hellberg A, Nickel R, Lotter H, Tannich E and Bruchhaus I 2001 Overexpression of cysteine proteinase 2 in Entamoeba histolytica or Entamoeba dispar increases amoeba-induced monolayer destruction in vitro but does not augment amoebic liver abscess formation in gerbils; Cell Microbiol. 3 13-20
12. Leippe M 1991 Comparison of pore-forming peptides from pathogenic and nonpathogenic Entamoeba histolytica; Mol. Biochem. Parasitol. 59 101-109
13. Leippe M 1995a Ancient weapons: NK-lysin is a mammalian homolog to pore-forming peptides of a protozoan parasite; Cell 83 17-18
14. Leippe M 1995b Spontaneous release of cysteine proteinases but not of pore-forming peptides by viable Entamoeba histolytica; Parasitology 111 569-574
15. Leippe M 1997 Amoebapores; Parasitol. Today 13 178-183
16. Leippe M, Andrä J and Müller-Eberhard H J 1994a Cytolytic and antibacterial activity of synthetic peptides derived from amebapore, the pore-forming peptide of Entamoeba histolytica; Proc. Natl. Acad. Sci. USA 91 2602-2606
17. Leippe M, Andrä J, Nickel R, Tannich E and Müller-Eberhard H J 1994b Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: Isolation, primary structure, and pore formation in bacterial cytoplasmic membranes; Mol. Microbiol. 14 895-904
18. Lieppe M, Ebel S, Schoenberger O L, Horstmann R D and Müller-Eberhard H J 1991 Pore-forming peptide of pathogenic Entamoeba histolytica; Proc. Natl. Acad. Sci. USA 88 7659-7663
19. Leippe M, Tannich E, Nickel R, van der Goot G, Pattus F, Horstmann R D and Müller-Eberhard H J 1992 Primary and secondary structure of the pore-forming peptide of pathogenic Entamoeba histolytica; EMBO J. 11 3501-3506
20. Lynch E C, Rosenberg I M and Gitler 1982 An ion-channel forming protein produced by Entamoeba histolytica; EMBO J. 1 801-804
21. Leippe M, Ebel S, Schoenberger O L, Horstmann R D and Müller-Eberhard H J 1992 Primary and secondary structure of the pore-forming peptide of pathogenic Entamoeba histolytica; EMBO J. 11 3501-3506
22. Moshitch-Moshkovitch S, Petter R, Stolarsky T and Mirelman D 1997 Regulation of expression of ribosomal protein L-21 genes of Entamoeba histolytica and E. dispar is at the posttranscriptional level; Mol. Microbiol. 27 677-685
23. Nickel R, Ott C, Dandekar T and Leippe M 1999 Pore-forming peptides of Entamoeba dispar: Similarity and divergence to amoebapores in structure, expression and activity; Eur. J. Biochem. 265 1002-1007
24. Nonaka G, Ishikawa T, Liu T T, Nakajima H and Kitamoto K 2000 Genetic analysis of growth inhibition of yeast cells caused by expression of Aspergillus oryzae RNase T1; Biosci. Biotechnol. Biochem. 64 2152-2158
25. Pena S V, Hanson D A, Carr B A, Goralski T J and Krensky A M 1997 Processing, subcellular localization, and function of 519 (Granulysin), a human late T cell activation molecule with homology to small, lytic granule proteins; J. Immunol. 158 2680-2688
26. Petter R, Moshitch S, Rozenblatt S, Nuchamowitz Y and Mirelman D 1994 Characterization of two distinct gene transcripts for ribosomal protein L21 from pathogenic and nonpathogenic strains of Entamoeba histolytica; Gene 150 181-186
27. Rosenberg I, Bach D, Loew L M and Gitler C 1989 Isolation, characterization and partial purification of a transferable membrane channel (amoebapore) produced by Entamoeba histolytica; Mol. Biochem. Parasitol. 33 237-248
28. Scherczinger C A, Yates A A and Knecht D A 1992 Variables affecting antisense RNA inhibition of gene expression; Ann. NY Acad. Sci. 660 45-56
29. Stenger S, Hanson D A, Teitelbaum R, Dewan P, Niazi K R, Froelich C J, Ganz T, Thoma-Uszynski S, Melian A, Bogdan C, Porcelli S A, Bloom B R, Krensky A M and Modlin R L 1998 An antimicrobial activity of cytolytic T cells mediated by granulsyin; Science 282 121-125
30. Vines R R, Purdy J E, Ragland B D, Samuelson J, Mann B J and Petri W A 1995 Stable episomal transfection of Entamoeba histolytica; Mol. Biochem. Parasitol. 71 265-267
31. Young J, Young T M, Lu P L, Unkeless J C and Cohn Z A 1982 Characterization of a membrane pore-forming protein from Entamoeba histolytica; J. Exp. Med. 156 1677-1690
32. Zhai Y and Saier M H 2000 The amoebapore superfamily; Biochim. Biophys. Acta 1469 87-99