Equilibrium expert: An add-in to Microsoft Excel for multiple binding equilibrium simulations and parameter estimations

Analytical Biochemistry

Volumn 310, Issue 1, 2002, Pages 1-14

  Raguin, Olivier ^a,b   Gruaz Guyon, Anne ^a,b   Barbet, Jacques ^a,c  

^a CNRS   (France)

^b HÔPITAL SAINT ANTOINE   (France)

^c INSTITUT DE BIOLOGIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR STRUCTURE;

BINDING EQUILIBRIA; BINDING PARAMETER; EXPERIMENTAL SYSTEM; MICROSOFT EXCEL; MOLECULAR SPECIES; NON-SPECIFIC BINDING; NONLINEAR LEAST SQUARE FITTING; PARTITION FUNCTIONS;

PARAMETER ESTIMATION;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; COMPUTER PROGRAM; COMPUTER SIMULATION; CONCENTRATION RESPONSE; COST; MEASUREMENT; PARTITION COEFFICIENT; PRIORITY JOURNAL;

EID: 0036855748     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(02)00289-0     Document Type: Article

References (36)

1. G. Scatchard, The attractions of proteins for small molecules and ions, Ann. N.Y. Acad. Sci. 51 (1949) 660-672.
2. P.J. Munson, D. Rodbard, Ligand: A versatile computerized approach for characterization of ligand-binding systems, Anal. Biochem. 107 (1980) 220-239.
3. B. Bellon, J. Jelsch, M. Delaage, Theory of multiple equilibria for polymers, Biochimie 55 (1973) 1159-1162.
4. J. Barbet, J.M. Le Doussal, A. Gruaz-Guyon, M. Martin, E. Gautherot, M. Delaage, Computer calculation of multiple binding equilibrium isotherms: Application to the binding of bivalent ligands to antibodies interacting with cell surface Fc-receptors, J. Theor. Biol. 165 (1993) 321-340.
5. M. Hillairet de Boisferon, O. Raguin, M. Dussaillant, W. Rostène, J. Barbet, A. Gruaz-Guyon, Enhanced targeting specificity to tumor cells by simultaneous recognition of two antigens, Bioconjug. Chem. 11 (2000) 452-460.
6. J.M. Le Doussal, A. Gruaz-Guyon, M. Martin, E. Gautherot, M. Delaage, J. Barbet, Targeting of indium-111-labeled bivalent hapten to human melanoma mediated by bispecific monoclonal antibody conjugates: Imaging of tumors hosted in nude mice, Cancer Res. 50 (1990) 3445-3452.
7. F.W. Wiegel, C. DeLisi, Evaluation of reaction rate enhancement by reduction in dimensionality, Am. J. Physiol. 243 (1982) R475-R479.
8. P.J. Munson, A User's Guide to LIGAND, Data Analysis and Curve-fitting for Ligand Binding Experiments, National Institutes of Health, Bethesda, MD, 1995.
9. F. Peters, A. Pingoud, Numerical analysis of binding studies: A direct procedure avoiding the pitfalls of a Scatchard analysis of equilibrium data for unknown binding models, Int. J. Biomed. Comput. 10 (1979) 401-415.
10. J.G. Norby, P. Ottolenghi, J. Jensen, Scatchard plot: Common misinterpretation of binding experiments, Anal. Biochem. 102 (1980) 318-320.
11. I.M. Klotz, Numbers of receptor sites from Scatchard graphs: Facts and fantasies, Science 217 (1982) 1247-1249.
12. P.J. Munson, D. Rodbard, Number of receptor sites from Scatchard and Klotz graphs: A constructive critique, Science 220 (1983) 979-981.
13. K. Zierler, Misuse of nonlinear Scatchard plots, Trends Biochem. Sci. 14 (1989) 314-317.
14. C.M. Mendel, D.B. Mendel, 'Non-specific' binding. The problem, and a solution, Biochem. J. 228 (1985) 269-272.
15. E.J. van Zoelen, Receptor-ligand interaction: A new method for determining binding parameters without a priori assumptions on non-specific binding, Biochem. J. 262 (1989) 549-556.
16. I.M. Klotz, D.L. Hunston, Protein interactions with small molecules. Relationships between stoichiometric binding constants, site binding constants, and empirical binding parameters, J. Biol. Chem. 250 (1975) 3001-3009.
17. W.C. Galley, M. Bouvier, S.D. Clas, G.R. Brown, L.E. St-Pierre, A simplified analysis of Scatchard plots for systems with two interacting binding sites, Biopolymers 27 (1988) 79-86.
18. S.I. Taylor, Binding of hormones to receptors. An alternative explanation of nonlinear Scatchard plots, Biochemistry 14 (1975) 2357-2361.
19. H.J. Hollemans, R.M. Bertina, Scatchard plot and heterogeneity in binding affinity of labeled and unlabeled ligand, Clin. Chem. 21 (1975) 1769-1773.
20. C.M. Mendel, V. Licko, J.P. Kane, The effect of ligand heterogeneity on the Scatchard plot. Particular relevance to lipoprotein binding analysis, J. Biol. Chem. 260 (1985) 3451-3455.
21. H.E. Gray, W.G. Luttge, Linearization of two ligand-one binding site Scatchard plot and the "IC50" competitive inhibition plot: Application to the simplified graphical determination of equilibrium constants, Life Sci. 42 (1988) 231-237.
22. T. Ishida, K. Horiike, H. Tojo, M. Nozaki, Interaction of protein with a self-associating ligand. Deviation from a hyperbolic binding curve and the appearance of apparent co-operativity in the Scatchard plot, J. Theor. Biol. 130 (1988) 49-66.
23. C. Wofsy, B. Goldstein, Interpretation of Scatchard plots for aggregating receptor systems, Math. Biosci. 112 (1992) 115-154.
24. P.J. Hogg, D.J. Winzor, Effects of ligand multivalency in binding studies: A general counterpart of the Scatchard analysis, Biochim. Biophys. Acta 843 (1985) 159-163.
25. J.B. Pedersen, W.E. Lindup, Interpretation and analysis of receptor binding experiments which yield non-linear Scatchard plots and binding constants dependent upon receptor concentration, Biochem. Pharmacol. 47 (1994) 179-185.
26. Y.I. Henis, A. Levitzki, An analysis on the slope of Scatchard plots, Eur. J. Biochem. 71 (1976) 529-532.
27. H. Almagor, A. Levitzki, Analytical determination of receptor-ligand dissociation constants of two populations of receptors from displacement curves, Proc. Natl. Acad. Sci. USA 87 (1990) 6482-6486.
28. E.J. van Zoelen, Analysis of receptor binding displacement curves by a nonhomologous ligand, on the basis of an equivalent competition principle, Anal. Biochem. 200 (1992) 393-399.
29. E.J. van Zoelen, R.H. Kramer, M.M. van Reen, J.H. Veerkamp, H.A. Ross, An exact general analysis of ligand binding displacement and saturation curves, Biochemistry 32 (1993) 6275-6280.
30. Z.X. Wang, An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule, FEBS Lett. 360 (1995) 111-114.
31. S.J. Harris, C.M. Jackson, D.J. Winzor, The rectangular hyperbolic binding equation for multivalent ligands, Arch. Biochem. Biophys. 316 (1995) 20-23.
32. Z.X. Wang, R.F. Jiang, A novel two-site binding equation presented in terms of the total ligand concentration, FEBS Lett. 392 (1996) 245-249.
33. G. Antoni, M. Mariani, An interactive computer program for the determination of the binding constants of monoclonal antibodies by non-linear regression analysis of radioimmunoassay data, J. Immunol. Methods 83 (1985) 61-68.
34. H.D. Quednau, M.L. Rao, A computerized approach towards the estimation of binding parameters to characterize cooperative and non-cooperative multicomponent ligand-receptor interactions, Int. J. Biomed. Comput. 16 (1985) 135-142.
35. D. Toptygin, L. Brand, Analysis of equilibrium binding data obtained by linear-response spectroscopic techniques, Anal. Biochem. 224 (1995) 330-338.
36. A. Ray, M. Maiti, A. Nandy, SCATPLOT: A computer program for determination of binding parameters of non-linear non-cooperative ligand-substrate interactions, Comput. Biol. Med. 26 (1996) 497-503.