Two CCAAT/enhancer binding protein sites are cis-activator elements of the Entamoeba histolytica EhPgp1 (mdr-like) gene expression

Cellular Microbiology

Volumn 4, Issue 11, 2002, Pages 725-737

  Marchat, L A Lawrence A ^a   Gómez, Consuelo ^a   Pérez, D Guillermo ^a   Paz, Francisco ^a   Mendoza, Leobardo ^b   Oroz, Esther ^b   Orozco, Esther ^b  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; MULTIDRUG RESISTANCE PROTEIN; NUCLEAR PROTEIN; UREA;

AFFINITY CHROMATOGRAPHY; BINDING SITE; CELL NUCLEUS; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; CYTOPLASM; DNA PROTEIN COMPLEX; DRUG SENSITIVITY; ENTAMOEBA HISTOLYTICA; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; IMMUNODETECTION; IMMUNOFLUORESCENCE; MOLECULAR CLONING; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; REVIEW; TROPHOZOITE; WESTERN BLOTTING;

ANIMALS; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; DRUG RESISTANCE, MULTIPLE; ENTAMOEBA HISTOLYTICA; GENE EXPRESSION REGULATION; HUMANS; MACROMOLECULAR SUBSTANCES; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; P-GLYCOPROTEIN; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTOZOAN PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

ENTAMOEBA; ENTAMOEBA HISTOLYTICA; PROTOZOA;

EID: 0036854563     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2002.00220.x     Document Type: Review

References (41)

1. Ausubel, F., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. (1994) Current Protocols in Molecular Biology. New York: John Wiley & Sons.
2. Ayala, P., Samuelson, J., Wirth, D., and Orozco, E. (1990) Entamoeba histolytica: Physiology of multidrug resistance. Exp Parasitol 71: 169-175.
3. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
4. Buß, H., Lioutas, C., Dobinsky, S., Nickel, R., and Tannich, E. (1995) Analysis of the 170 kDa lectin gene promoter of Entamoeba histolytica. Mol Biochem, Parasitol 72: 1-10.
5. Cereghini, S., Raymondjean, M., Garcia, C.A., Herbomel, P., and Yaniv, M. (1987) Factors involved in control of tissue-specific expression of albumin gene. Cell 50: 627-638.
6. Combates, N.J., Rzepka, R.W., Pan Chen, Y.N., and Cohen, D. (1994) NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter. J Biol Chem 269: 29715-29719.
7. Cowman, A.F., Galatis, D., and Thompson, J.K. (1994) Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the Pfmdr1 gene and cross- resistance to halofanthrine and quinine. Proc Natl Acad Sci USA 91: 1143-1147.
8. Dallagiovanna, B., Castanys, S., and Gamarro, F. (1994) Trypanosoma cruzi: sequence of the ATP-binding site of a P-glycoprotein. Exp Parasitol 79: 63-67.
9. Dano, K. (1973) Active outward transport of daunomycin in resistant Erlich ascites tumor cells. Biochem Biophys Acta 323: 466-483.
10. Descoteaux, S., Ayala, P., Orozco, E., and Samuelson, J. (1992) Primary sequences of two P-glycoprotein genes of Entamoeba histolytica. Mol Biochem, Parasitol 54: 212.
11. Descoteaux, S., Ayala, P., Samuelson, J., and Orozco, E. (1995) Increase in mRNA of multiple EhPgp genes encoding P-glycoprotein homologues in emetine-resistant Entamoeba histolytica. Gene 164: 179-184.
12. Diamond, L.S., Harlow, R., and Cunnick, C. (1978) A new medium for the axenic cultivation of Entamoeba histolytica and another Entamoeba. Trans R Soc Trop Med Hyg 73: 431-432.
13. Endicott, J.A., and Ling, V. (1989) The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58: 137-171.
14. Foote, S.T., Thompson, J.K., Cowman, A.F., and Kemp, D.J. (1989) Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of Plasmodium. Cell 57: 921-930.
15. Gilchrist, C.A., Holm, C.F., Hughes, M.A., Schaenman, J.M., Mann, B.J., and Petri, W.A., Jr (2001) Identification and characterization of an Entamoeba histolytica upstream regulatory element 3 sequence-specific DNA-binding protein containing EF-hand motifs. J Biol Chem 276: 11838-11843.
16. Gómez, C., Pérez, D.G., López-Bayghen, E., and Orozco, E. (1998) Transcriptional analysis of the EhPgp1 promoter of Entamoeba histolytica multidrug-resistant mutant. J Biol Chem 273: 7277-7284.
17. Hernández, R., Luna-Arias, J.P., and Orozco, E. (1997) Comparison of the Entamoeba histolytica TATA-binding protein (TBP) structure with other TBP. Arch Med Res 28: S43-S45.
18. Hidalgo, M.E., and Orozco, E. (1997) Structural characterization of the Entamoeba histolytica enolase gene promoter. Arch Med Res 28: S46-S48.
19. Higgins, C.F. (1993) The multidrug resistance P-glycoprotein. Curr Opin Cell Biol 5: 684-687.
20. Johnson, P.J., Schuk, B.L., and Delgadillo, M.G. (1994) Analysis of a single domain P-glycoprotein-like gene in the early-diverging protist Trichomonas vaginalis. Mol Biochem Parasitol 66: 127-137.
21. Katakura, K., Iwanami, M., Ohtomo, H., Fujise, H., and Hashiguchi, V. (1999) Structural and functional analysis of the LaMDR1 multidrug resistance gene in Leishmania amazonensis. Biochem Biophys Res Commun 255: 289-294.
22. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
23. Loo, T.W., and Clarke, D.M. (1999) Molecular dissection of the human multidrug resistance P-glycoprotein. Biochem Cell Biol 77: 11-23.
24. López-Bayghen, E., Vega, A., Cadena, A., Granados, S.E., Gariglio, P., and Alvarez-Salas, L.M. (1996) Transcriptional analysis of the. 5′-noncoding region of the human involucrin gene. J Biol Chem 271: 512-520.
25. Luna-Arias, J.P., Hernández-Rivas, R., de Dios-Bravo, G., Garcia, J., Mendoza, L., and., and Orozco, E. (1999) The TATA-box binding protein of Entamoeba histolytica: cloning of the gene and location of the protein by immunofluorescence and confocal microscopy. Microbiology 145: 33-40.
26. Marchat, L.A., Gómez, C., Pérez, D.G., López, C., and Orozco, E. (2000) Possible role of the CCAAT/Enhancer Binding Protein in the expression regulation of the EhPgp1 multidrug resistance gene in Entamoeba histolytica. Arch Med Res 31: S2911-S293.
27. McKnight, S.L. (1992) CCAAT/enhancer binding protein. In Transcriptional Regulation. McKnight, S.L., and Yamamoto, K.R. (eds). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory pp. 771-795.
28. Nickel, R., and Tannich, E. (1994) Transfection and transient expression of chloramphenicol acetyltransferase gene in the protozoan parasite Entamoeba histolytica. Proc Natl Acad Sci USA 91: 7095-7098.
29. Orozco, E., Hernández, F., and Rodriguez, M. (1985) Isolation and characterization of. Entamoeba histolytica mutants resistant to emetine. Mol Biochem Parasitol 15: 49-59.
30. Orozco, E., Pérez, D.G., Gómez, M.C., and Ayala, P. (1995) Multidrug resistance in. Entamoeba histolytica. Parasitol Today 11: 473-475.
31. Orozco, E., Gómez, C., and Pérez, D.G. (1999) Physiology and molecular genetics of multidrug resistance in Entamoeba histolytica. Drug Resistance Updates 2: 188-197.
32. Orozco, E., Gharaibeh, R., Riveron, A.M., Delgadillo, D.M., Mercado, M., Sánchez, T., et al. (1997) A novel cytoplasmic structure containing DNA networks in Entamoeba histolytica trophozoites. Mol General Genet 254: 250-257.
33. Ouellette, M., and Papadopoulou, B. (1993) Mechanisms of drug resistance in. Leishmania Parasitol Today 9: 150-153.
34. Pérez, D.G., Gómez, C., López-Bayghen, E., Tannich, E., and Orozco, E. (1998) Transcriptional analysis of the EhPgp5 promoter of Entamoeba histolytica multidrug-resistant mutant. J Biol Chem 273: 7285-7292.
35. Purdy, J.E., Pho, L.T., Mann, B.J., and Petri, W.A. Jr (1996) Upstream regulatory elements controlling expression of the Entamoeba histolytica lectin. Mol Biochem Parasitol 78: 91-103.
36. Sanger, F., Nickel, S., and Coulson, A.R. (1977) DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci USA 74: 5463-5467.
37. Schaenman, J.M., Gilchrist, C.A., Mann, B.J., and Petri, W.A. Jr (2001) Identification of two Entamoeba histolytica sequence-specific URE4 Enhancer-binding proteins with homology to the RNA-binding motif RRM. J Biol Chem 276: 1602-1609.
38. Schreiber, E., Matthias, P., Muller, M.M., and Schaffner, W. (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17: 6419.
39. Singh, U., and Rogers, J.B. (1998) The novel core promoter element GAAC in the hgl5 gene of Entamoeba histolytica is able to direct a transcription start site independent of TATA or initiator regions. J Biol Chem 273: 21663-21668.
40. Upcroft, J.A., and Upcroft, P. (1993) Drug resistance and Giardia. Parasitol Today 9: 187-190.
41. Yu, L., Wu, Q., Huang, Y.C., and Horwitz, S.B. (1995) Coordination of transcription factors, NF-Y and C/EBP beta, in the regulation of the mdr1b promoter. Cell Growth Diff 6: 1505-1512.