Drosophila HB9 is expressed in a subset of motoneurons and interneurons, where it regulates gene expression and axon pathfinding

Journal of Neuroscience

Volumn 22, Issue 21, 2002, Pages 9143-9149

  Odden, Joanne P ^a   Holbrook, Scott ^a   Doe, Chris Q ^a  

^a UNIVERSITY OF OREGON   (United States)

Author keywords

Axonogenesis; Even skipped; HB9; Interneuron; MNR2; Motoneuron; Serotonergic

Indexed keywords

HOMEODOMAIN PROTEIN; PROTEIN; PROTEIN HB9; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM; CHICKEN; DROSOPHILA; GENE EXPRESSION; INTERNEURON; METAZOON; MOTONEURON; MOUSE; NERVE FIBER; NERVE GROWTH; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VERTEBRATE;

DROSOPHILA;

EID: 0036849877     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-21-09143.2002     Document Type: Article

References (23)

1. Arber S, Han B, Mendelsohn M, Smith M, Jessell TM, Sockanathan S (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23:659-674.
2. Bellomonte D, Di Bernardo M, Russo R, Caronia G, Spinelli G (1998) Highly restricted expression at the ectoderm-endoderm boundary of PIHbox 9, a sea urchin homeobox gene related to the human HB9 gene. Mech Dev 74:185-188.
3. Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401-415.
4. Broihier HT, Skeath JB (2002) Drosophila homeodomain protein dHb9 directs neuronal fate via crossrepressive and cell-nonautonomous mechanisms. Neuron 35:39-50.
5. Campbell G, Goring H, Lin T, Spana E, Andersson S, Doe CQ, Tomlinson A (1994) RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. Development 120:2957-2966.
6. Chu-LaGraff Q, Schmid A, Leidel J, Bronner G, Jackle H, Doe CQ (1995) Huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding. Neuron 15:1041-1051.
7. Ferrier DE, Brooke NM, Panopoulou G, Holland PW (2001) The Mnx homeobox gene class defined by HB9, MNR2 and amphioxus AmphiMnx. Dev Genes Evol 211:103-107.
8. Gorczyca MG, Phillis RW, Budnik V (1994) The role of tinman, a mesodermal cell fate gene, in axon pathfinding during the development of the transverse nerve in Drosophila. Development 120:2143-2152.
9. Harrison KA, Druey KM, Deguchi Y, Tuscano JM, Kehrl JH (1994) A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues. J Biol Chem 269:19968-19975.
10. Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH (1999) Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet 23:71-75.
11. Isshiki T, Pearson B, Holbrook S, Doe CQ (2001) Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny. Cell 106:511-521.
12. Landgraf M, Roy S, Prokop A, VijayRaghavan K, Bate M (1999) Even-skipped determines the dorsal growth of motor axons in Drosophila. Neuron 22:43-52.
13. Lundell MJ, Chu-LaGraff Q, Doe CQ, Hirsh J (1996) The engrailed and huckebein genes are essential for development of serotonin neurons in the Drosophila CNS. Mol Cell Neurosci 7:46-61.
14. Moran-Rivard L, Kagawa T, Saueressig H, Gross MK, Burrill J, Goulding M (2001) Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord. Neuron 29:385-399.
15. Novotny T, Eiselt R, Urban J (2002) Hunchback is required for the specification of the early sublineage of neuroblast 7-3 in the Drosophila central nervous system. Development 129:1027-1036.
16. Saha MS, Miles RR, Grainger RM (1997) Dorsal-ventral patterning during neural induction in Xenopus: Assessment of spinal cord regionalization with xHB9, a marker for the motor neuron region. Dev Biol 187:209-223.
17. Schmid A, Chiba A, Doe CQ (1999) Clonal analysis of Drosophila embryonic neuroblasts: Neural cell types, axon projections and muscle targets. Development 126:4653-4689.
18. Sullivan W, Ashburner M, Hawley SR (1999) Drosophila Protocols. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
19. Tanabe Y, William C, Jessell TM (1998) Specification of motor neuron identity by the MNR2 homeodomain protein. Cell 95:67-80.
20. Thaler J, Harrison K, Sharma K, Lettieri K, Kehrl J, Pfaff SL (1999) Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9. Neuron 23:675-687.
21. Thor S, Thomas JB (1997) The Drosophila islet gene governs axon pathfinding and neurotransmitter identity. Neuron 18:397-409.
22. Thor S, Andersson SG, Tomlinson A, Thomas JB (1999) A LIM-homeodomain combinatorial code for motor-neuron pathway selection. Nature 397:76-80.
23. Vactor DV, Sink H, Fambrough D, Tsoo R, Goodman CS (1993) Genes that control neuromuscular specificity in Drosophila. Cell 73:1137-1153.