Histologic-genetic mapping by allele-specific PCR reveals intraurothelial spread of p53 mutant tumor clones

Laboratory Investigation

Volumn 82, Issue 11, 2002, Pages 1553-1561

  Stoehr, Robert ^a   Knuechel, Ruth ^a   Boecker, Joerg ^a   Blaszyk, Hagen ^a   Schmitt, Ruediger ^a   Filbeck, Thomas ^a   Hofstaedter, Ferdinand ^a   Hartmann, Arndt ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN P53;

ADULT; AGED; ALLELE; ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CELL SPREADING; CYSTECTOMY; FEMALE; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE; UROTHELIUM;

EID: 0036847948     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000035022.29742.85     Document Type: Article

References (38)

1. Baud E, Catilina P, Boiteux JP, and Bignon YJ (1998). Human bladder cancers and normal bladder mucosa present the same hot spot of heterozygous chromosome-9 deletion. Int J Cancer 77:821-824.
2. n repeat alterations. Trends Genet 12:450-451.
3. Bottema CD and Sommer SS (1993). PCR amplification of specific alleles: Rapid detection of known mutations and polymorphisms. Mutat Res 288:93-102.
4. Chaturvedi V, Li L, Hodges S, Johnston D, Ro JY, Logothetis C, von Eschenbach AC, Batsakis JG, and Czerniak B (1997). Superimposed histologic and genetic mapping of chromosome 17 alterations in human urinary bladder neoplasia. Oncogene 14:2059-2070.
5. Chow NH, Cairns P, Eisenberger CF, Schoenberg MP, Taylor DC, Epstein JI, and Sidransky D (2000). Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer. Int J Cancer 89:514-518.
6. Cordon-Cardo C, Cote RJ, and Sauter G (2000). Genetic and molecular markers of urothelial premalignancy and malignancy. Scand J Urol Nephrol Suppl 205:82-93.
7. Czerniak B, Chaturvedi V, Li L, Hodges S, Johnston D, Ro JY, Luthra R, Logothetis C, Eschenbach C, Grossman HB, Benedict W, and Batsakis JG (1999). Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: Implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer. Oncogene 18:1185-1196.
8. Czerniak B, Li L, Chaturvedi V, Ro JY, Johnston DA, Hodges S, and Benedict WF (2000). Genetic modeling of human urinary bladder carcinogenesis. Genes Chromosom Cancer 27:392-402.
9. Dalbagni G, Ren ZP, Herr H, Cordon-Cardo C, and Reuter V (2001). Genetic alterations in TP53 in recurrent urothelial cancer: A longitudinal study. Clin Cancer Res 7:2797-2801.
10. Habuchi T, Takahashi R, Yamada H, Kakehi Y, Sugiyama T, and Yoshida O (1993). Metachronous multifocal development of urothelial cancers by intraluminal seeding. Lancet 342:1087-1088.
11. Hafner C, Knuechel R, Zanardo L, Dietmaier W, Blaszyk H, Cheville J, Hofstaedter F, and Hartmann A (2001). Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract. Oncogene 20:4910-4915.
12. Hainaut P, Dogliotti E, Hernandez T, D'Errico M, and DeMarini DM (1998). Mutation spectra resulting from carcinogenic exposure: From model systems to cancer-related genes. Recent Results Cancer Res 154:97-127.
13. Hainaut P and Hollstein M (2000). p53 and human cancer: The first ten thousand mutations. Adv Cancer Res 77:81-137.
14. Harris AL and Neal DE (1992). Bladder cancer-field versus clonal origin (Editorial; comment). N Engl J Med 326:759-761.
15. Harris CC (1996). The 1995 Walter Hubert Lecture - Molecular epidemiology of human cancer: Insights from the mutational analysis of the p53 tumor-suppressor gene. Br J Cancer 73:261-269.
16. Hartmann A, Blaszyk H, McGovem RM, Schroeder JJ, Cunningham J, De Vries EM, Kovach JS, and Sommer SS (1995). p53 gene mutations inside and outside exons 5-8: The patterns differ in breast and other cancers. Oncogene 10:681-688.
17. Hartmann A, Moser K, Kriegmair M, Hofstetter A, Hofstaedter F, and Knuechel R (1999). Frequent genetic alterations in simple urothelial hyperplasias of the bladder in patients with papillary urothelial carcinoma. Am J Pathol 154:721-727.
18. Hartmann A, Rosner U, Schlake G, Dietmaier W, Zaak D, Hofstaedter F, and Knuechel R (2000). Clonality and genetic divergence in multifocal low-grade superficial urothelial carcinoma as determined by chromosome 9 and p53 deletion analysis. Lab Invest 80:709-718.
19. Hartmann A, Schlake G, Zaak D, Hungerhuber E, Hofstetter A, Hofstaedter F, and Knuchel R (2002). Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder. Cancer Res 62:809-818.
20. Koss LG (1979). Mapping of the urinary bladder: Its impact on the concepts of bladder cancer. Hum Pathol 10:533-548.
21. Kram A, Li L, Zhang RD, Yoon DS, Ro JY, Johnston D, Grossman HB, Scherer S, and Czerniak B (2001). Mapping and genome sequence analysis of chromosome 5 regions involved in bladder cancer progression. Lab Invest 81:1039-1048.
22. Levine AJ (1997). p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
23. Mostofi FK, Davis CJJ, and Sesterhenn IA (1999). Histological typing of urinary bladder tumours. In: World Health Organization-International Histological Classification. Berlin: Springer.
24. Muto S, Horie S, Takahashi S, Tomita K, and Kitamura T (2000). Genetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer. Cancer Res 60:4021-4025.
25. Paiss T, Woehr G, Hautmann RE, Mattfeldt T, Mueller M, Haeussler J, and Vogel W (2002). Some tumors of the bladder are polyclonal in origin. J Urol 167:718-723.
26. Park IW, Wistuba II, Maitra A, Milchgrub S, Virmani AK, Minna JD, and Gazdar AF (1999). Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer. J Natl Cancer Inst 91:1863-1868.
27. Rossi MR, Masters JRW, Park S, Todd JH, Garrett SH, Sens MA, Somji S, Nath J, and Sens DA (2001). The immortalized UROtsa cell line as a potential cell culture model of human urothelium. Environ Health Perspect 109:801-808.
28. Schutze K and Lahr G (1998). Identification of expressed genes by laser-mediated manipulation of single cells. Nat Biotechnol 16:737-742.
29. Sidransky D, Frost P, Von Eschenbach A, Oyasu R, Preisinger AC, and Vogelstein B (1992). Clonal origin bladder cancer. N Engl J Med 326:737-740.
30. Simon R, Eltze E, Schaefer KL, Buerger H, Semjonow A, Hertle L, Dockhorn-Dworniczak B, Terpe HJ, and Boecker W (2001). Cytogenetic analysis of multifocal bladder cancer supports a monoclonal origin and intraepithelial spread of tumor cells. Cancer Res 61:355-362.
31. Simoneau M, Aboulkassim TO, LaRue H, Rousseau F, and Fradet Y (1999). Four tumor suppressor loci on chromosome 9q in bladder cancer: Evidence for two novel candidate regions at 9q22.3 and 9q31. Oncogene 18:157-163.
32. Slaughter DP, Southwick HW, and Smejkal W (1953). "Field cancerization" in oral stratified squamous epithelium. Clinical implications of multicentric origin. Cancer 6:963-968.
33. Sobin LH and Wittekind CH (1997). TNM Classification of Malignant Tumours. Sobin LH and Wittekind CH, editors. New York: Wiley-Liss, 187-194.
34. Spruck CH III, Ohneseit PF, Gonzalez-Zulueta M, Esrig D, Miyao N, Tsai YC, Lerner SP, Schmutte C, Yang AS, and Cote R (1994). Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res 54:784-788.
35. Stoehr R, Hartmann A, Hiendlmeyer E, Murle K, Wieland W, and Knuechel R (2000). Oligoclonality in early lesions of the urothelium as determined by microdissection-supported genetic analysis. Pathobiology 68:165-172.
36. Tabor MP, Brakenhoff RH, van Houten VMM, Kummer JA, Snel MHJ, Snijders PJF, Snow GB, Leemans CR, and Braakhuis BJM (2001). Persistence of genetically altered fields in head and neck cancer patients: Biological and clinical implications. Clin Cancer Res 7:1523-1532.
37. Takahashi T, Kakehi Y, Mitsumori K, Akao T, Terachi T, Kato T, Ogawa O, and Habuchi T (2001). Distinct microsatellite alterations in upper urinary tract tumors and subsequent bladder tumors. J Urol 165:672-677.
38. Yoon DS, Li L, Zhang RD, Kram A, Ro JY, Johnston D, Grossman HB, Scherer S, and Czerniak B (2001). Genetic mapping and DNA sequence-based analysis of deleted regions on chromosome 16 involved in progression of bladder cancer from occult preneoplastic conditions to invasive disease. Oncogene 20:5005-5014.