Patients with coronary artery disease who present with chest pain have significantly elevated platelet contractile force and clot elastic modulus

Thrombosis and Haemostasis

Volumn 88, Issue 5, 2002, Pages 739-744

  Krishnaswami, Ashok ^a   Carr Jr , Marcus E ^a   Jesse, Robert L ^a   Kontos, Michael C ^a   Minisi, Anthony J ^a   Ornato, Joseph P ^a   Vetrovec, George W ^a   Martin, Erika J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Angina; Coronary artery disease; Platelet aggregation; Platelet contractile force

Indexed keywords

ADULT; AGED; ANALYZER; ANGINA PECTORIS; ARTICLE; BLOOD CLOT; CARDIOVASCULAR RISK; CLOT ELASTIC MODULUS; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DEVICE; DISEASE MARKER; ELECTROCARDIOGRAPHY; EMERGENCY WARD; EVIDENCE BASED MEDICINE; FEMALE; HEART MUSCLE ISCHEMIA; HEMODYNAMIC PARAMETERS; HEMOSTASIS; HOSPITAL ADMISSION; HUMAN; LABORATORY; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; MEDICAL DOCUMENTATION; OUTCOMES RESEARCH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STATISTICAL SIGNIFICANCE; THORAX PAIN; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE CONTRACTILE FORCE; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; BIOMECHANICS; BLOOD; BLOOD CLOT RETRACTION; BLOOD CLOTTING PARAMETERS; CASE CONTROL STUDY; CORONARY ARTERY ATHEROSCLEROSIS; HOSPITALIZATION; MIDDLE AGED; PHYSIOLOGY; RACE; STATISTICS; THROMBOCYTE;

ADULT; AGED; AGED, 80 AND OVER; BIOMECHANICS; BLOOD PLATELETS; CASE-CONTROL STUDIES; CHEST PAIN; CLOT RETRACTION; CONTINENTAL POPULATION GROUPS; CORONARY ARTERIOSCLEROSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; SEVERITY OF ILLNESS INDEX;

EID: 0036847477     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613295     Document Type: Article

References (35)

1. Kristensen SD, Lassen JF, Ravn HB. Pathopysiology of coronary thrombosis. Semin Interv Cardiol 2000; 5: 109-15.
2. Fitzgerald DJ, Louis R, Catella F, Fitzgerald GA. Platelet activation in unstable coronary disease. N Engl J Med 1986; 315: 983-9.
3. Willerson JT, Campbell WB, Winniford MD, Schmitz J, Apprill P, Firth BG, Ashton J, Smitherman T, Bush L, Buja LM. Conversion from chronic to acute coronary artery disease: Speculation regarding mechanisms. Am J Cardiol 1984; 54: 1349-54.
4. Buja ML, Willerson JT. Clinicopathologic correlates of acute ischemic heart disease syndromes. Am J Cardiol 1981; 47: 343-56.
5. Willerson JT, Golino P, Eidt J, Campbell WB, Buja LM. Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications. Circulation 1989; 80: 198-205.
6. Lee TH, Rouan GW, Weisberg MC, Brand DA, Acampora D, Stasiulewicz C, Walshon J, Terranova G, Gottlieb L, Goldstein-Wayne B, et al. Clinical characteristics and natural history of patients with acute myocardial infarction sent home from the emergency room. Am J Cardiol 1987; 60: 219-24.
7. McCarthy BD, Beshansky JR, D'Agostino RB, Selker HP. Missed diagnoses of acute myocardial infarction in the emergency department: results from a multicenter study. Ann Emerg Med 1993; 22: 579-82.
8. Kontos MC, Jesse RL, Schmidt KL, Ornato JP, Tatum JL. Value of acute rest sestamibi perfusion imaging for evaluation of patients admitted to the emergency department with chest pain. JACC 1997; 30: 976-82.
9. Varetto T, Cantalupi D, Altieri A, Orlandi C. Emergency room technetium-99m sestambi imaging to rule out acute myocardial ischemic events in patients with nondiagnostic electrocardiograms. JACC 1993; 22: 1804-8.
10. Hilton TC, Thompson RC, Williams HJ, Saylors R, Fulmer H, Stowers SA. Technetium-99m sestamibi myocardial perfusion imaging in the emergency room evaluation of chest pain. JACC 1994; 23: 1016-22.
11. Lindahl B, Diderholm E, Lagerqvist B, Venge P, Wallentin L. Mechanisms behind the prognostic value of troponin T in unstable coronary artery disease: a FRISC II substudy. J Am Coll Cardiol 2001; 38: 979-86.
12. Ohman EM, Armstrong PW, Christenson RH, Granger CB, Katus HA, Hamm CW, O'Hanesian MA, Wagner GS, Kleiman NS, Harrell FE Jr, Califf RM, Topol EJ. Cardiac troponin T levels for risk stratification acute myocardial ischemia. N Engl J Med 1996; 335: 1333-41.
13. Trip MD, Cats VM, van Capelle FJ, Vreeken J. Platelet hyperreactivity and prognosis in survivors of myocardial infarction. N Engl J Med 1990; 322: 1549-54.
14. Ikeda H, Nakayama H, Oda T, Kuwano K, Muraishi A, Sugi K, Koga Y, Toshima H. Soluble form of P-selectin in patients with acute myocardial infarction. Coron Artery Dis 1994; 5: 515-8.
15. Shyu KG, Chang H, Lin CC, Kuan P. Circulating intercellular adhesion molecule-1 and E-selectin in patients with acute coronary syndrome. Chest 1996; 109: 1627-30.
16. Greilich PE, Carr ME, Zekert SL, Dent RM. Quantitative Assessment of Platelet Function and Clot Structure in Patients with Severe Coronary Artery Disease. Am J Med Sci 1994; 307: 15-20.
17. Carr ME. Measurement of platelet force: the Hemodyne® hemostasis analyzer. Clin Lab Manage Rev 1995; 9: 312-9.
18. Carr ME, Zekert SL. Measurement of platelet-mediated force development during plasma clot formation. Am J Med Sci 1991; 302: 13-8.
19. Carr ME, Martin EJ, Carr SL. Delayed, reduced or inhibited thrombin production reduces platelet contractile force and results in weaker clot formation. Blood Coagul Fibrinolysis 2002; 13; 193-7.
20. Tatum JL, Jesse RL, Kontos MC, Nicholson CS, Schmidt KL, Roberts CS, Ornato JP. Comprehensive strategy for the evaluation and triage of the chest pain patient. Ann Emerg Med 1997; 29: 116-25.
21. Carr ME, Zekert SL. Abnormal clot retraction, altered fibrin structure, and normal platelet function in multiple myeloma. Am J Physiol 1994; 266; H1195-201.
22. Carr ME, Carr SL. Fibrin structure and concentration alter clot elastic modulus but do not alter platelet mediated force development. Blood Coagul Fibrinolysis 1995; 6: 79.
23. Becker RC, Bovill EG, Corrao JM, Ball SP, Ault K, Mann KG, Tracy RP. Dynamic nature of thrombin generation, fibrin formation, and platelet activation in unstable angina and non-Q-wave myocardial infarction. J Thromb Thrombolysis 1995; 2: 57-64.
24. Tataru MC, Schulte H, von Eckardstein A, Heinrich J, Assmann G, Koehler E. Plasma fibrinogen in relation to the severity of arteriosclerosis in patients with stable angina pectoris after myocardial infarction. Coron Artery Dis 2001; 12: 157-65.
25. Johnsson R, Harjola PT, Siltanen P. Effect of pentoxifylline on red cell flexibility in arterio-sclerotic patients and in patients with heart value prosthesis. Scand J Clin Lab Suppl 1981; 156: 297-300.
26. Carr ME Jr, Carr SL, Hantgan RR, Braaten J. Glycoprotein IIb/IIIa Blockade Inhibits Platelet Mediated Force Development and Reduces Gel Elastic Modulus. Thromb Haemost 1995; 73: 499-505.
27. Carr ME, Carr SL, Greilich PE. Heparin ablates force development during platelet mediated clot retraction. Thromb Haemost 1996; 75: 674-8.
28. Rho R, Tracy RP, Bovill EG, Ball SP, Becker RC. Plasma markers of procoagulant activity among individuals with coronary artery disease. J Throm Thrombolysis 1995; 2: 239-43.
29. Figueras J, Monasterio Y, Lidon RM, Nieto E, Soler-Soler J. Thrombin formation and fibrinolytic activity in patients with acute myocardial infarction or unstable angina: in-hospital course and relationship with recurrent angina at rest. J Am Coll Cardiol 2000; 36: 2036-43.
30. McKenzie ME, Pothula A, Gurbel PA, Fuzaylov SY, O'Connor CM, Gattis WA, Serebruany VL. Failure of thrombin generation markers to triage patients presenting with chest pain. Cardiology 1999; 92: 53-8.
31. Neumann FJ, Ott I, Gawaz M, Puchner G, Schomig A. Neutrophil and platelet activation at baloon-injured coronary artery plaque in patients undergoing angioplasty. J Am Coll Cardiol 1996; 27: 819-24.
32. Prazich JA, Rapaport SI, Samples JR, Engler R. Platelet aggregate ratios - standardization of technique and test results in patients with myocardial ischemia and patients with cerebrovascular disease. Thromb Haemost 1997; 38: 597-605.
33. Jaffy MB, Meischke H, Eisenberg MS. Prevalence of aspirin use among patients calling 9-1-1 for chest pain. Acad Emerg Med 1998; 5: 1146-9.
34. Garcia-Dorado D, Theroux P, Tornos P, Sambola A, Oliveras J, Santos M, Soler Soler J. Previous aspirin use may attenuate the severity of the manifestation of acute ischemic syndromes. Circulation 1995; 92: 1743-8.
35. Carr ME Jr, Hines S, Carr SL, Todd WM, Taylor TL, Mohanty L. Storage pool disease in chronic lymphocytic leukemia: abnormal aggregation and secretion without bleeding. Am J Med Sci 1997; 313: 176-81.