Kinetic analysis of covalent binding between N-acetyl-L-cysteine and albumin through the formation of mixed disulfides in human and rat serum in vitro

Pharmaceutical Research

Volumn 19, Issue 11, 2002, Pages 1648-1654

  Harada, D ^a   Naito, S ^a   Otagiri, M ^b  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Covalent binding; Kinetic analysis; Mixed disulfide; N acetyl L cysteine; Serum albumin

Indexed keywords

ACETYLCYSTEINE; ALBUMIN; CARBON 14; CYSTEINE; DISULFIDE;

ANIMAL EXPERIMENT; ANION EXCHANGE; ARTICLE; BINDING KINETICS; CHROMATOGRAPHY; COVALENT BOND; DISSOCIATION CONSTANT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; RADIOACTIVITY; RADIOCHROMATOGRAPHY; RAT; SERUM; SPECIES DIFFERENCE;

ACETYLCYSTEINE; ANIMALS; DISULFIDES; HUMANS; MALE; PHARMACOKINETICS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN;

EID: 0036846825     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020749211745     Document Type: Article

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