The effect of micronized estradiol on bone turnover and calciotropic hormones in older men receiving hormonal suppression therapy for prostate cancer

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 11, 2002, Pages 4907-4913

  Taxel, Pamela ^a   Fall, Pamela M ^a   Albertsen, Peter C ^a   Dowsett, Robert D ^a   Trahiotis, Margaret ^a   Zimmerman, Jill ^a   Ohannessian, Christine ^a   Raisz, Lawrence G ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE BONE ISOENZYME; BIOLOGICAL MARKER; CALCITRIOL; CALCIUM ION; COLLAGEN TYPE 1; DEOXYPYRIDINOLINE; ESTRADIOL; ESTRONE; GONADORELIN AGONIST; OSTEOCALCIN; PARATHYROID HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADVANCED CANCER; AGED; ARTICLE; BONE TURNOVER; BREAST TENDERNESS; CANCER ADJUVANT THERAPY; CANCER HORMONE THERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG WITHDRAWAL; ESTROGEN THERAPY; HORMONE BLOOD LEVEL; HOT FLUSH; HUMAN; MALE; MOOD DISORDER; OSSIFICATION; OSTEOLYSIS; PRIORITY JOURNAL; PROSTATE CANCER; RANDOMIZED CONTROLLED TRIAL;

ALKALINE PHOSPHATASE; AMINO ACIDS; BONE REMODELING; CALCIFEDIOL; CALCITRIOL; CALCIUM; COLLAGEN; COLLAGEN TYPE I; DOUBLE-BLIND METHOD; ESTRADIOL; ESTRONE; GONADOTROPIN-RELEASING HORMONE; OSTEOCALCIN; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PEPTIDES; PLACEBOS; PROCOLLAGEN; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 0036846403     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020539     Document Type: Article

References (26)

1. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, Edwards BK, eds 2000 SEER Cancer Statistics Review, 1973-1998, Bethesda: NCI; NIH Pubication 00-2789
2. Garnick M, Leuprolide Study Group 1984 Leuprolide versus diethylstilbesterol for metastatic prostate cancer. N Engl J Med 311:1281-1286
3. Higgins C, Hodges C 1941 Studies in prostate cancer. I. The effects of castration, of estrogen, and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1:293-297
4. Sharifi RS, Bruskewitz RC, Gittleman MC, Graham Jr SD, Hudson PB, Stein B 1996 Leuprolide acetate 22.5 mg 12-week depor formulation in the treatment of patients with advanced prostate cancer. Clin Therapeut 18:647-657
5. Townsend MF, Sanders WH, Northway RO, Graham Jr SD 1997 Bone fractures associated with luteinizing hormone-releasing hormone agonists used in the treatment of prostate carcinoma. Cancer 79:545-550
6. Hatano T, Oishi Y, Futura A, Iwamuro S, Tashiro K 2000 Incidence of bone fracture in patients receiving luteinizing hormone-releasing hormone agonists for prostate cancer. Br J Urol Int 86:449-452
7. Daniell HW 1997 Osteoporosis after orchiectomy for prostate cancer. J Urol 157:439-444
8. Khosla S, Melton LJ, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL 1998 Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen. J Clin Endocrinol Metab 83:2266-2274
9. Greendale GA, Edelstein S, Barrett-Connor E 1997 Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo Study. J Bone Miner Res 12:1833-1843
10. Center JR, Nguyen TV, Sambrook PN, Eisman JA 1999 Hormonal and biochemical parameters in the determination of osteoporosis in older men. J Clin Endocrinol Metab 84:3626-3635
11. Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnstom CC 1997 Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens. J Clin Invest 100:1755-1759
12. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS 1994 Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331:1056-1061
13. Morishma A, Grumbach MM, Simpson ER, Fisher C, Qin K 1995 Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80:3689-3698
14. Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER 1997 Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337:91-95
15. Simpson E, Rubin G, Clyne C, Robertson K, O'Donnell L, Davis S, Jones M 1999 Local estrogen biosynthesis in males and females. Endocr Relat Cancer 6:131-137
16. Falahati A, Riggs BL, Atkinson EJ, O'Fallon WM, Khosla S 2000 Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men, J Clin Invest 106:1553-1560
17. Leder BZ, Schoenfeld DA, LeBlanc K, Finkelstein JS 2001 Both estradiol and testosterone play fundamental roles m the maintenance of normal bone turnover in men. J Bone Miner Res 10(Suppl):S171
18. Smith MR, McGovern FJ, Zietman AL, Fallon MA, Hayden DL, Schoenfeld DA, Kantoff PW, Finkelstein JS 2001 Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. N Engl J Med 345:948-955
19. Taxel P, Kennedy DG, Fall PM, Willard AK, Clive JM, Raisz LG 2001 The effect of aromatase inhibition on sex steroids, gonadotropins and markers of bone turnover in older men. J Clin Endocrinol Metab 86:2869-2874
20. Hannon R, Blumsohn A Naylor K, Eastell R 1998 Response of biochemical markers of bone remover to hormone replacement therapy: Impact of biological variability. J Bone Miner Res 13:1124-1133
21. Stoch SA, Parker RA, Chen L, Bubley G, Ko YJ, Vincelette A, Greenspan SL 2001 Bone loss in men with prostate cancer treated with gonadotropin-releasing hormone agonists. J Clin Endocrinol Metab 86:2787-2791
22. Fairney A, Peters J, Veneam M 1998 Bone loss and prostate cancer. Bone 23/5S:S302
23. Scherr D, Pitts Jr WR, Vaughn Jr D 2002 Diethylstilbesterol revisited: Androgen deprivation, osteoporosis and prostate cancer. J Urol 167:535-538
24. Carlstrom K, Stege R, Henriksson P, Grande M, Gunnarsson PO, Pousette A 1997 Possible bone-preserving capacity of high-dose intramuscular depor estrogen as compared to orchidectomy in the treatment of patients with prostatic carcinoma. Prostate 31:193-197
25. Khosla S, Atkinson EJ, Melton III J, Riggs BL 1997 Effects of age and estrogen status on serum parathyroid levels and biochemical markers of bone turnover in women: A population-based study. J Clin Endocrinol Metab 82:1522-1527
26. Raisz LG, Wiita B, Artis A, Bowen A, Schwartz S, Trahiotis M, Shoukri K, Smith J 1996 Comparison of the effects of estrogen alone and estrogen plus androgen on markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol Metab 81:37-43