Gemcitabine (Gemzar®)-based induction chemotherapy in non-small-cell lung cancer

Lung Cancer

Volumn 38, Issue 2 SUPPL., 2002, Pages 13-19

  Scagliotti, Giorgio Vittorio ^a   Novello, Silvia ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Chemotherapy; Gemcitabine; Non small cell lung cancer

Indexed keywords

CARBOPLATIN; CISPLATIN; GEMCITABINE; IFOSFAMIDE; MITOMYCIN; NAVELBINE; PACLITAXEL; VINBLASTINE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; DRUG DERIVATIVE;

ANEMIA; ANTINEOPLASTIC ACTIVITY; ARTHRALGIA; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFICACY; DRUG TOLERANCE; ESOPHAGITIS; HUMAN; HYPERSENSITIVITY; LUNG NON SMALL CELL CANCER; MORBIDITY; MULTIMODALITY CANCER THERAPY; MYALGIA; NEUTROPENIA; OTOTOXICITY; PNEUMONIA; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE; RADIATION INJURY; SURVIVAL RATE; THORACOTOMY; THROMBOCYTOPENIA; TREATMENT FAILURE; TREATMENT OUTCOME; CONTROLLED CLINICAL TRIAL; DISEASE FREE SURVIVAL; LUNG TUMOR; PATHOLOGY; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; REVIEW;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CISPLATIN; CLINICAL TRIALS, PHASE II; CLINICAL TRIALS, PHASE III; DEOXYCYTIDINE; DISEASE-FREE SURVIVAL; HUMANS; LUNG NEOPLASMS; NEOPLASM STAGING; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME;

EID: 0036844814     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0169-5002(02)00352-5     Document Type: Conference Paper

References (37)

1. Non-Small Cell Lung Cancer Collaborative Group . Chemotherapy in non-small cell lung cancer: meta-analysis using updated data on individual patients from 52 randomized clinical trials. Br. Med. J. 311:1995;899-909.
2. Crino L., Scagliotti G.V., Ricci S., De Marinis F., Rinaldi M., Gridelli C., et al. Gemcitabine and cisplatin versus mitomycin, ifosfamide, and cisplatin in advanced non-small-cell lung cancer: a randomized phase III study of the Italian Lung Cancer Project. J. Clin. Oncol. 17:1999;3522-3530.
3. Cardenal F., Lopez-Cabrerizo M.P., Anton A., Anton A., Alberola V., Massuti B., et al. Randomized phase III study of gemcitabine-cisplatin versus etoposide-cisplatin in the treatment of locally advanced or metastatic non-small-cell lung cancer. J. Clin. Oncol. 17:1999;8-12.
4. Bonomi P., Kim K., Fairclough D., Cella D., Kugler J., Rowinsky E., et al. Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group trial. J. Clin. Oncol. 18:2000;623-631.
5. The European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group, Giaccone G., Splinter T.A., Debruyne C., Kho G.S., Lianes P., van Zandwijk N., et al. Randomized study of paclitaxel-cisplatin versus cisplatin-teniposide in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 16:1998;2133-2141.
6. Rinaldi M., Crino L., Scagliotti G.V., Mosconi A.M., Marinis D.e, Gridelli F., et al. A 3-week schedule of gemcitabine-cisplatin in advanced non-small-cell lung cancer with two different cisplatin dose levels: a phase II randomized trial. Ann. Oncol. 11:2000;1295-1300.
7. Perez C.A., Stanley K., Grundy G., et al. Impact of irradiation technique and tumor extent in tumor control and survival of patients with unresectable non-small-cell lung carcinoma: report by the Radiation Therapy Oncology Group. Cancer. 50:1982;1091-1099.
8. Hazuka M.B., Turrisi A.T., Lutz S.T., et al. Results of high dose thoracic irradiation incorporating beam's eye view display in non-small cell lung cancer: a retrospective multivariate analysis. Int. J. Radiat. Oncol. Biol. Phys. 27:1993;273-284.
9. Dillman R.O., Seagren S.L., Propert K.J., et al. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. New Engl. J. Med. 323:1990;940-945.
10. Le Chevalier T., Arriagada R., Quoix E., et al. Radiotherapy alone versus combined chemotherapy and radiotherapy in non-resectable non-small-cell lung cancer: first analysis of a randomized trial in 353 patients. J. Natl. Cancer Inst. 83:1991;417-423.
11. Sause W.T., Scott C., Taylor S., et al. Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer. J. Natl. Cancer Inst. 87:1995;198-205.
12. Byhardt R.W., Scott C., Sause W.T., et al. Response toxicity failure patterns, and survival in five Radiation Therapy Oncology Group (RTOG) trials for sequential and/or concurrent chemotherapy and radiotherapy for locally advanced non-small-cell carcinoma of the lung. Int. J. Radiat. Oncol. Biol. Phys. 42:1988;469-478.
13. Scalliet P., Goor C., Galdermans D., et al. Gemzar (gemcitabine) with thoracic radiotherapy - a phase II pilot study in chemonaive patients with advanced non-small cell lung cancer (NSCLC). Proc. Am. Soc. Clin. Oncol. 17:1998;499a.
14. Fossella F.V., Zinner R.G., Komaki R., et al. Gemcitabine (G) with concurrent chest radiation (XRT) followed by consolidation chemotherapy with gemcitabine plus cisplatin (CDDP): a phase I trial for patients with stage III non-small cell lung cancer (NSCLC). Proc. Am. Soc. Clin. Oncol. 20:2001;312a. Abstract 1243.
15. Vokes E.E., Leopold K.A., Herndon J.E., et al. CALGB study 9431: a randomized phase II study of cisplatin with gemcitabine or paclitaxel or vinorelbine with cisplatin as induction chemotherapy (Ind CT) and concomitant chemoradiotherapy (XRT) for unresectable stage III non-small cell lung cancer (NSCLC). Lung Cancer. 29:(Suppl. 1):2000;29. Abstract 158.
16. Rosell R., Lòpez-Cabrenizo M.P., Astudillo J. Preoperative chemotherapy for stage IIIA non-small cell lung cancer. Curr. Opin. Oncol. 9:1996;149-155.
17. Roberts J.R., DeVore R.F., Carbone D.P., et al. Neoadjuvant chemotherapy increases perioperative complications in patients undergoing resection for NSCLC. Ann. Thorac. Surg. 72:2001;885-888.
18. Siegenthaler M.P., Pisters K.M., Merriman K.W., et al. Preoperative chemotherapy for lung cancer does not increase surgical morbidity. Ann. Thorac. Surg. 71:2001;1105-1111.
19. Van Raemdonck D.E., Schneider A., Ginsberg R.J. Surgical treatment for higher stage non-small cell lung cancer. Ann. Thorac. Surg. 54:1992;999-1013.
20. Andre F., Grunenwald D., Pignon J.P., et al. Survival of patients with resected N2 non-small cell lung cancer: evidence for a subclassification and implications. J. Clin. Oncol. 18:(16):2000;2981-2989.
21. Rosell R., Gomez-Codina J., Camps C., et al. A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with NSCLC. New Engl. J. Med. 330:1994;153-158.
22. Roth J.A., Fosella F., Komaki R., et al. A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA NSCLC. J. Natl. Cancer Inst. 86:1994;673-680.
23. Roth J.A., Atkinson E.N., Fossella F., et al. Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. Lung Cancer. 21:1998;1-6.
24. Rosell R., Gomez-Codina J., Camps C., et al. Preresectional chemotherapy in stage IIIA non-small-cell lung cancer: a 7-year assessment of a randomized controlled trial. Lung Cancer. 28:2000;247-251.
25. Van Zandwijk N., Smit E.F., Kramer G.W., et al. Gemcitabine and cisplatin as induction regimen for patients with biopsy-proven stage IIIA N2 non-small-cell lung cancer: a phase II study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group (EORTC 08955). J. Clin. Oncol. 18:2000;2658-2664.
26. Van Kooten M., Rosenberg J., Morero R., Chacon R., Orlando M. Phase II study of gemcitabine plus cisplatin as induction regimen for patients with stage IIIA-IIIB non-small cell lung cancer. Proc. Am. Soc. Clin. Oncol. 18:1999;526a. Abstract 2028.
27. Yang C.H., Tsai C.M., Wang L.S., et al. A phase II feasibility trial of gemcitabine and cisplatin before local treatment in locally advanced non-small cell lung cancer. Proc. Am. Soc. Clin. Oncol. 18:1999;528a. Abstract 2035.
28. Crinò L., Betti M., Gregorc V., et al. Induction chemotherapy with gemcitabine and cisplatin in locally advanced stage III non-small cell lung cancer. A phase II study. Proc. Am. Soc. Clin. Oncol. 18:1999;488a. Abstract 1883.
29. Rubio I., Lopez-Vivanco G., Barcelo J., et al. Preoperative treatment with cisplatin-gemcitabine in locally advanced NSCLC: survival, toxicity and salvage therapy. Eur. J. Cancer. 35:(Suppl. 4):1999;S256. Abstract 1018.
30. Crinò L., De Marinis F., Scagliotti G., et al. Neoadjuvant chemotherapy with gemcitabine and platinum in unresectable stage III non-small cell lung cancer (NSCLC): a phase II experience with a new schedule. Proc. Am. Soc. Clin. Oncol. 20:2001;329a. Abstract 1311.
31. Santo A., Calabrò F., Tummarello D., et al. Neo-adjuvant chemotherapy with gemcitabine and cisplatin in stage IIIAN2/IIIB non-small cell lung cancer. A multicenter phase II study with a 21 days schedule. Proc. Am. Soc. Clin. Oncol. 20:2001;342a. Abstract 1364.
32. Passlick B., Izbicki J.R., Kubuschok B., et al. Detection of disseminated lung cancer cells in lymph nodes: impact on staging and prognosis. Ann. Thorac. Surg. 61:1996;177-182.
33. Cote R.J., Hawes D., Chaiwun B., et al. Detection of occult metastases in lung carcinomas: progress and implications for lung cancer staging. J. Surg. Oncol. 69:1998;265-274.
34. Ohgami A., Mitsudomi T., Sugio K., et al. Micrometastatic tumor cells in the bone marrow of patients with non-small cell lung cancer. Ann. Thorac. Surg. 64:1997;363-367.
35. Bimodality Lung Oncology Team, Pisters K.M., Ginsberg R.J., Giroux D.J., et al. Induction chemotherapy before surgery for early-stage lung cancer: a novel approach. J. Thorac. Cardiovasc. Surg. 119:2000;429-439.
36. de Boer R.H., Smith I.E., Pastorino U., et al. Pre-operative chemotherapy in early stage resectable non-small-cell lung cancer: a randomized feasibility study justifying a multicentre phase III trial. Br. J. Cancer. 79:1999;1514-1518.
37. Depierre A., Milleron B., Moro-Sibilot D., et al. Preoperative chemotherapy followed by surgery compared with primary surgery in resectable stage I (except T1N0), II, and IIIa non-small cell lung cancer. J. Clin. Oncol. 20:2002;247-253.