Chronic fatigue syndrome and immune dysfunction: Cause or effect?

Israel Medical Association Journal

Volumn 4, Issue 11 SUPPL., 2002, Pages 883-885

  Pollack, Shimon ^a  

^a RAMBAM MEDICAL CENTER   (Israel)

Author keywords

2 5A syntherase Rnase L; ABC transporters; Chronic fatigue syndrome; Immune dysfunction; Viral infection

Indexed keywords

ABC TRANSPORTER; ANTINUCLEAR ANTIBODY; COLD AGGLUTININ; CRYOGLOBULIN; CYTOKINE; GLIADIN ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; ION CHANNEL; RHEUMATOID FACTOR; RIBONUCLEASE; RIBONUCLEASE L; SMOOTH MUSCLE ANTIBODY; THYROID ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY TITER; AUTOIMMUNITY; BED REST; CELL FUNCTION; CELL PROLIFERATION; CHRONIC FATIGUE SYNDROME; CLINICAL OBSERVATION; CONFERENCE PAPER; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; EMOTIONAL STRESS; ENZYME ACTIVITY; ENZYME DEGRADATION; EXERCISE TOLERANCE; FLU LIKE SYNDROME; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOGLOBULIN PRODUCTION; IMMUNOPATHOLOGY; IMMUNOREGULATION; LYMPHOCYTE SUBPOPULATION; MORBIDITY; NATURAL KILLER CELL; NEUROPSYCHOLOGICAL TEST; PATHOGENESIS; RECURRENT DISEASE; RISK FACTOR; SOCIOECONOMICS; SYMPTOM; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION; VIRUS REACTIVATION;

ANTIBODY FORMATION; AUTOANTIBODIES; CASE-CONTROL STUDIES; CHRONIC DISEASE; CYTOKINES; FATIGUE; FATIGUE SYNDROME, CHRONIC; HUMANS; IMMUNE SYSTEM DISEASES; ION CHANNELS; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; VIRUS ACTIVATION; VIRUS DISEASES;

EID: 0036844245     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. Fukuda K, Strauss SE, Hickie I, Sharpe MC, Dobbins JG Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 1994;121:953-9.
2. Komaroff AL, Fagioli LR, Doolittle TH, et al. Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups. Am J Med 1996;101:281-90.
3. Holmes GP, Kaplan JE, Gantz NM, et al. Chronic fatigue syndrome: a working case definition. Ann Intern Med 1988;108:387-9.
4. Theorell T, Blomkvist V, Lindh G, Evengard B. Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): an examination of CFS patients and subjects with a nonspecific life crisis. Psychosom Med 1999;61:304-10.
5. Whiteside TL, Friberg D. Natural killer cells and natural killer cell activity in chronic fatigue syndrome. Am J Med 1998;105:27-34S.
6. Ogawa M, Nishiura T, Yoshimura M, et al. Decreased nitric oxide-mediated natural killer cell activation in chronic fatigue syndrome. Eur J Clin Invest 1998;28:937-943.
7. Mawle AC, Nisenbaum R, Dobbins JG, et al. Immune responses associated with chronic fatigue syndrome: a case-control study. J Infect Dis 1997;175:136-41.
8. Lloyd AR, Hickie I, Brockman A, et al. Immunologic and psychologic therapy for patients with chronic fatigue syndrome: a double-blind, placebo-controlled trial. Am J Med 1993;94:197-203.
9. Von Mikecz A, Konstantinov K, Buchwald DS, Gerace L, Tan EM. High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome. Arthritis Rheum 1997;40:295-305.
10. Demettre E, Bastide L, D'Haese A, et al. Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients. J Biol Chem 2002;227:35745-51.
11. Fremont M, D'Haese A, Roelens S, De Smet K, Vincent Herst C, Englebienne P. immune cell apoptosis and chronic fatigue syndrome. In: Englebienne P, DeMeirleir K, eds. Chronic Fatigue Syndrome: A Biological Approach. New York: CRB Press, 2002;131-73.
12. Shetzline SE, Martinand-Mari C, Reichenbach NL, et al. Structural and functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome. J Interferon Cytokine Res 2002;22:443-56.
13. Englebienne P, Herst CV, D'Haese A, et al. Ribonuclease L inhibitor: a member of the ATP-Binding cassette superfamily. In: Englebienne P, DeMeirler K, eds. Chronic Fatigue Syndrome: A Biological Approach. New York: CRC Press, 2002:73-97.