Immunotoxic and cancerostatic effects of ethyl-4-isothiocyanatobutanoate in female Lewis rats with implanted fibrosarcoma

International Immunopharmacology

Volumn 2, Issue 12, 2002, Pages 1681-1691

  Sovcikova, Andrea ^a   Tulinska, Jana ^b   Chalupa, Ivan ^c   Liskova, Aurelia ^b   Kuricova, Miroslava ^b   Horvathova, Mira ^b   Seemannova, Zuzana ^a   Horakova, Katarina ^a  

^a SLOVAK UNIVERSITY OF TECHNOLOGY   (Slovakia)

^b INST OF PREV AND CLINICAL MEDICINE   (Slovakia)

^c CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

Anticancer effect; BP6 TU2 fibrosarcoma cells; E 4IB; Ethyl 4 isothiocyanatobutanoate; Immunotoxicity assays; Lewis rats

Indexed keywords

ANTINEOPLASTIC AGENT; DIMETHYL SULFOXIDE; ETHYL 4 ISOTHIOCYANATOBUTANOATE; HEMOGLOBIN; ISOTHIOCYANIC ACID DERIVATIVE; MITOGENIC AGENT; SODIUM CHLORIDE; UNCLASSIFIED DRUG; BUTYRIC ACID DERIVATIVE; ETHYL 4-ISOTHIOCYANATOBUTANOATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD TOXICITY; CANCER CELL; CANCER SIZE; CANCER TRANSPLANTATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG MEGADOSE; EOSINOPHIL; ERYTHROCYTE COUNT; FEMALE; FIBROSARCOMA; HEMOGLOBIN DETERMINATION; IMMUNOCOMPETENT CELL; IMMUNOTOXICITY; LEUKOCYTE COUNT; LEUKOCYTOSIS; LYMPH NODE; LYMPHOCYTE COUNT; MAXIMUM TOLERATED DOSE; MONOCYTE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; SPLEEN CELL; SPLEEN WEIGHT; THYMUS; ANIMAL; B LYMPHOCYTE; BODY WEIGHT; CYTOLOGY; DRUG EFFECT; EXPERIMENTAL NEOPLASM; IMMUNOLOGY; LEUKOCYTE; LEWIS RAT; ORGAN SIZE; SPLEEN; T LYMPHOCYTE;

ANIMALS; ANTINEOPLASTIC AGENTS; B-LYMPHOCYTES; BODY WEIGHT; BUTYRATES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROSARCOMA; ISOTHIOCYANATES; LEUKOCYTES; NEOPLASMS, EXPERIMENTAL; ORGAN SIZE; PHAGOCYTOSIS; RATS; RATS, INBRED LEW; SPLEEN; T-LYMPHOCYTES;

EID: 0036842543     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(02)00164-9     Document Type: Article

References (20)

1. Fenwick G.R., Heaney R.K., Mullin W.J. Glucosinolates and their breakdown products in food and food plants. Crit. Rev. Food Sci. Nutr. 18:1983;123-201.
2. Hecht S.S. Chemoprevention by isothiocyanates. J. Cell. Biochem., Suppl. 22:1995;195-209.
3. Talalay P., Zhang Y. Chemoprotection against cancer by isothiocyanates and glucosinolates. Biochem. Soc. Trans. 24:1996;806-810.
4. Zhang Y., Talalay P. Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic phase 2 enzymes. Cancer Res. 58:1998;4632-4639.
5. Horakova K., Strakova Z., Jantova S., Muckova M., Floch L. Biological effects of 2-isothiocyanatecarboxylic acid esters: I. Cytotoxic, antimicrobial and genotoxic screening of aminoacid isothiocyanate derivatives. [in Slovak] Biológia. 44:1989;637-646.
6. Sovcikova A., Mikulasova M., Horakova K., Floch L. Antibacterial and mutagenic activities of new isothiocyanate derivatives. Folia Microbiol. (Prague). 46(2):2001;113-117.
7. Horakova K., Jantova S., Stredansky M., Novotna L., Floch L. Ethyl 4-isothiocyanatobutanoate - antiproliferative activity in vitro and in vivo. Anti-Cancer Drugs. 4:1993;369-375.
8. Tulinska J., Sovcikova A., Liskova A., Kubova J., Horakova A. Immunotoxicity of ethyl-4-isothiocyanatobutanoate in male Wistar rats. Toxicology. 145:2000;217-225.
9. Floch L., Kovac S. Synthesis and properties of alkyl isothiocyanatocarboxylates. Collect. Czechoslov. Chem. Commun. 40:1975;2845-2854.
10. Fornusek L., Vetvicka V., Kopecek E. Differences in phagocytic activity of methacrylate copolymer particles in normal and stimulated macrophages. Experientia. 37:1981;418-420.
11. Cunningham A.J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 14:1968;559-600.
12. Smialowicz R.J. Burleson B.R., Dean J.H., Munson A.E. Methods in Immunotoxicology. 1995;71-108 Wiley-Liss, New York.
13. Luster M.I., Munson A.E., Thomas P.T., Holsapple M.P., Fenters J.D., White K.L.et al. Development of a testing battery to assess chemical-induced immunotoxicity: National Toxicology Program's guidelines for immunotoxicity evaluation in mice. Fundam. Appl. Toxicol. 10:1988;2.
14. Van Loveren H., Vos J.G. Immunotoxicological consideration: a practical approach to immunotoxicity tests in the rat. Dayan A.D., Paine A.J. Advances Applied Toxicology. 1989;143-164 Taylor and Francis, New York.
15. Descotes J. Immunotoxicology of immunomodulators. Dev. Biol. Stand. 77:1992;99-102.
16. The ICICIS Group Investigators Report of validation study of assessment of direct immunotoxicity in the rat. Toxicology. 125:1998;183-201.
17. Pugh P.A., Tervit H.R., Niemann H. Effects of vitrification medium composition on the survival of bovine in vitro produced embryos, following in straw-dilution, in vitro and in vivo following transfer. Anim. Reprod. Sci. 58(1-2):2000;9-22.
18. Avery B., Greve T. Effects of ethanol and dimethylsulphoxide on nuclear and cytoplasmic maturation of bovine cumulus-oocyte complexes. Mol. Reprod. Dev. 55(4):2000;438-445.
19. Sjogren F., Anderson C. The spectrum of inflammatory cell response to dimethyl sulfoxide. Contact Dermatitis. 42(4):2000;216-221.
20. Nakamura H., Kawasaki N., Hagiwara M., Saito M., Konaka C., Kato H. Cellular immunologic parameters related to age, gender, and stage in lung cancer patients. Lung Cancer. 28(2):2000;139-145.