Naloxone decreases insulin secretion in hyperinsulinemic postmenopausal women and may positively affect hormone replacement therapy

Fertility and Sterility

Volumn 78, Issue 5, 2002, Pages 1017-1024

  Cucinelli, Francesco ^a   Soranna, Liberato ^b   Perri, Concetta ^a   Romualdi, Daniela ^a   Barini, Angela ^a   Mancuso, Salvatore ^a   Lanzone, Antonio ^a,b  

^a CATHOLIC UNIVERSITY   (Italy)

^b OASI RESEARCH INSTITUTE IRCCS   (Italy)

Author keywords

c peptide; HRT; Insulin; Menopause; Naloxone; Opioids

Indexed keywords

C PEPTIDE; CARBOHYDRATE; GESTAGEN; GLUCOSE; INSULIN; NALOXONE; OPIATE RECEPTOR; SODIUM CHLORIDE;

ADULT; ARTICLE; CARBOHYDRATE METABOLISM; CLAMP; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; ESTROGEN THERAPY; EXTRACTION; FEMALE; GLUCOSE BLOOD LEVEL; HEALTH STATUS; HORMONE SUBSTITUTION; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; MENOPAUSE; METABOLISM; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; POSTMENOPAUSE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; REGULATORY MECHANISM;

AREA UNDER CURVE; C-PEPTIDE; DRUG SYNERGISM; ESTROGEN REPLACEMENT THERAPY; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; INSULIN; INSULIN ANTAGONISTS; MIDDLE AGED; NALOXONE; NARCOTIC ANTAGONISTS; POSTMENOPAUSE; PROSPECTIVE STUDIES; SODIUM CHLORIDE;

EID: 0036842430     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(02)03369-1     Document Type: Article

References (39)

1. Walton C., Godsland I.F., Proudler A.J., Wynn V., Stevenson J.C. The effect of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women. Eur J Clin Invest. 23:1993;466-473.
2. Bailey C., Ahmed-Sorour H. Role of ovarian hormones in the long-term control of glucose homeostasis. Diabetologia. 19:1980;475-481.
3. Godsland I.F., Crook D., Stevenson J.C., Collins P., Rosano J.M.C., Lees B., et al. The insulin resistance syndrome in postmenopausal women with cardiological syndrome X. British Heart J. 74:1995;47-52.
4. Grandison L., Guidotti A. Stimulation of food intake by muscimol and beta-endorphin. Neuropharmacology. 16:1997;533.
5. Cozzolino D., Sessa G., Salvatore T., Sasso F.C., Giugliano D., Lefebvre P.J., et al. The involvement of the opioid system in the human obesity a study in normal weight relatives of obese people . J Clin Endocrinol Metab. 81:1996;713-718.
6. Giugliano D., Torella R., Lefebvre P.J., D'Onofrio F. Opioid peptides and metabolic regulation. Diabetologia. 31:1988;3-15.
7. Bruni J.F., Watkins W.B., Yen S.S.C. Beta-endorphin in the human pancreas. J Clin Endocrinol Metab. 49:1979;649-651.
8. Ipp E., Dobbs R., Unger R.H. Morphine and beta-endorphin influence the secretion of the endocrine pancreas. Nature. 276:1978;190-191.
9. Chuong C.J., Smith, Yi Tsong. Beta-endorphin levels in the human menstrual cycle. Acta Obstet Gynecol Scand. 68:1989;497-501.
10. Genazzani A.R., Petraglia F., Facchinetti F., Grasso A., Alessandrini G., Volpe A. Steroid replacement treatment increases beta-endorphin and beta-lipotropin plasma levels in postmenopausal women. Gynecol Obstet Invest. 26:1988;153-159.
11. D'Amico J.F., Greendale G.A., Lu J.K., Judd H.L. Induction of hypothalamic opioid activity with transdermal estradiol administration in postmenopausal women. Fertil Steril. 55:1991;754-758.
12. Shoupe D., Montz F.J., Lobo R.A. The effects of estrogen and progestin on endogenous opioid activity in oophorectomized women. J Clin Endocriol Metab. 60:1985;178.
13. Grodstein F., Stampfer M.J., Manson J.A.E., Colditz G.A., Willet W.C., Rosner B., et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med. 335:1996;453-461.
14. Cucinelli F., Paparella P., Soranna L., Barini A., Cinque B., Mancuso S., et al. Differential effect of transdermal estrogen plus progestagen replacement therapy on insulin metabolism in postmenopausal women relation to their insulinemic secretion . Eur J Endocrinol. 140:1999;215-223.
15. Pasquali R., Cantobelli S., Casimirri F., Bortoluzzi L., Boschi S., Capelli M., et al. The role of the opioid peptides in the development of hyperinsulinemia in obese women with abdominal body fat distribution. Metabolism. 41:1992;763-767.
16. Percheron C., Colette C., Mariano-Goulart D., Avignon A., Capeyron O., Boniface H., et al. Relationship between insulin sensitivity obesity body fat distribution and B-endorphinemia in obese women. Int J Obesity. 22:1998;143-148.
17. Chetkowski R.J., Meldrum D.R., Steingold K.A. Biological effect of transdermal estradiol. N Engl J Med. 314:1986;1615-1620.
18. Lanzone A., Fulghesu A.M., Fortini A., Cutillo G., Cucinelli F., Di Simone N., et al. Effect of opiate receptor blockade on the insulin response to oral glucose load in polycystic ovarian disease. Hum Reprod. 6:1991;1043-1049.
19. Bergman R.N., Finegood D.T., Ader M. Assessment of insulin sensitivity in vivo. Endocr Rev. 6:1985;45-75.
20. Alberti K.G., Zimmet P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabetes Med. 15:1998;539-553.
21. Lanzone A., Fulghesu A.M., Cucinelli F., Ciampelli M., Caruso A., Mancuso S. Evidence of a distinct derangement of opioid tone in hyperinsulinemic patients with polycyctic ovarian syndrome relationship with insulin and luteinizing hormone secretion . J Clin Endocrinol Metab. 12:1995;3501-3506.
22. Bonadonna R.C., Groop L., Kraemer N., Ferrannini E., Del Prato S., DeFronzo R.A. Obesity and insulin resistance in humans a dose response study . Metabolism. 39:1990;452-459.
23. Faber O.K., Christensen K., Ketlem H., Madsbad S., Binder C. Decreased insulin removal contributes to hyperinsulinemia in obesity. J Clin Endocriol Metab. 53:1981;618-621.
24. World Health Organization . Measuring obesity-classification and description of anthropometrics data. 1988;WHO Regional Office for Europe, Copenhagen. EUR/ICP/NUT 125-0612 V.
25. Isles C.G., Hole D.J., Hawthorne V.M., Lever V.F. Relation between coronary risk and coronary mortality in women of the Renfrev and Paisley survey comparison with men. Lancet. 339:1992;702-706.
26. Gangar K.F., Vyas S., Whitehead M., Crook D., Meire H., Campbell S. Pulsatility index in internal carotid artery in relation to transdermal oestradiol and time since menopause. Lancet. 338:1991;839-842.
27. Stevenson J.C., Crook D.C., Godsland I.F. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis. 98:1993;83-90.
28. Winkler U.H. Menopause hormone replacement therapy and cardiovascular disease a review of haemostaseological findings . Fibrinolysis. 6:(Suppl 3):1992;5-10.
29. Ley C.J., Lees B., Stevenson J.C. Sex and menopause associated changes in body fat distribution. Am J Clin Nutr. 55:1992;950-954.
30. Godsland I.F. The influence of female sex steroids on glucose metabolism and insulin action. J Int Med. 240:(Suppl 738):1996;1-65.
31. Armenau M., Berkhout G.M.J., Schoemaker J. Pulsatile luteinizing hormone secretion in hypothalamic amenorrhea, anorexia nervosa, and polycystic ovarian disease during naltrexone treatment. Fertil Steril. 57:1992;762-770.
32. Reid R.L., Quigley M.E., Yen S.S.C. The disappearance of opioidergic regulation of gonadotropin secretion in postmenopausal women. J Clin Endocrinol Metab. 57:1983;1107.
33. Genazzani A.R., Gastaldi M., Bidzinska B., Mercuri N., Genazzani A.D., Nappi R.E., et al. The brain as a target organ of gonadal steroids. Psychoneuroendocrinology. 17:1992;385-390.
34. Wardlaw S.L., Weherenberg W.B., Ferin M., Antunes J.L., Frantz A.G. Effect of sex steroid on β-endorphin in hypophiseal portal blood. J Clin Endocrinol Metab. 55:1982;877.
35. Recant L., Voyles N., Wade A., Awoke S., Bathena S. Study on the roles of the opiates in two forms of genetic obesity ob/ob mouse and fa/fa rats . Horm Metab Res. 15:1983;589-593.
36. Orwell E.S., Kendall J.W. β-endorphin and adrenocorticotropin in extra pituitary sites gastrointestinal tract . Endocrinology. 107:1980;438-442.
37. Guido M., Pavone V., Ciampelli M., Murgia F., Fulghesu A.M., Lanzone A., et al. Involvement of ovarian steroids in the opioid mediated reduction of insulin secretion in hyperinsulinemic patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 83:1998;1742-1745.
38. Wittert G., Hope P., Pyle D. Tissue distribution of opioid receptor gene expression in the rat. Biochem Biophys Res Commun. 218:1996;877-881.
39. Cagnacci A., Melis G.B., Soldani R., Paoletti A.M., Gambacciani M., Spinetti A., et al. Neuroendocrine and clinical effects of transdermal 17 beta estradiol in postmenopausal women. Maturitas. 13:1991;283-296.