Function of native OmtA in vivo and expression and distribution of this protein in colonies of Aspergillus parasiticus

Applied and Environmental Microbiology

Volumn 68, Issue 11, 2002, Pages 5718-5727

  Lee, Li Wei ^a   Chiou, Ching Hsun ^a   Linz, John E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CHROMATOGRAPHY; AFLATOXINS; ANTIBODIES; BIOSYNTHESIS; CELLS; ENZYMES; ESCHERICHIA COLI; FLUORESCENCE; TISSUE;

FUNGAL COLONIES;

FUNGI;

AFLATOXIN; FUNGAL PROTEIN; HYBRID PROTEIN; MYCOTOXIN; O METHYLSTERIGMATOCYSTIN; PROTEIN OMTA; STERIGMATOCYSTIN; UNCLASSIFIED DRUG;

ENZYME;

ARTICLE; ASPERGILLUS PARASITICUS; CATALYSIS; CHEMICAL REACTION; ENZYME ACTIVITY; ENZYME PURIFICATION; ESCHERICHIA COLI; IMMUNOHISTOCHEMISTRY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TOXIN SYNTHESIS; WESTERN BLOTTING;

ASPERGILLUS; ASPERGILLUS PARASITICUS; ESCHERICHIA COLI; FUNGI;

EID: 0036841220     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.68.11.5718-5727.2002     Document Type: Article

References (35)

1. Akesson, H., E. Carlemalm, E. Everitt, T. Gunnarsson, G. Odham, and H.-B. Jansson. 1996. Immunocytochemical localization of phytotoxins in Bioplaris sorokiniana. Fungal Genet. Biol. 20:205-216.
2. Arseculeratne S. N., L. M. De Silva, S. Wijesundera, and C. H. S. R. Bandunatha. 1969. Coconut as a medium for the experimental production of aflatoxin. Appl. Microbiol. 18:88-94.
3. Ausubel, F. M., R. Brent, E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 2001. Current Protocols in Molecular Biology. John Wiley and Sons, New York, N.Y.
4. Belozerskaya, T. A. 1998. Cell-to-cell communication in differentiation of mycelial fungi. Membr. Cell Biol. 11:831-840.
5. Bhatnagar, D., S. P. McCormick, L. S. Lee, and R. A. Hill. 1987. Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus. Appl. Environ. Microbiol. 53:1028-1033.
6. Bhatnagar, D., A. H. Ullah, and T. E. Cleveland. 1988. Purification and characterization of a methyltransferase from Aspergillus parasiticus SRRC 163 involved in aflatoxin biosynthetic pathway. Prep. Biochem. 18:321-349.
7. Bhatnagar, D., T. E. Cleveland, and E. B. Lillehoj. 1989. Enzymes in aflatoxin B1 biosynthesis: Strategies for identifying pertinent genes. Mycopathologia 107:75-83.
8. Bratthauer, G. R. 1999. Processing of tissue specimens, p. 77-84. In L. C. Javois (ed.), Methods in Molecular Biology. Humana Press, Totowa, N.J.
9. Cary, J., J. Linz, and D. Bhatnagar. 2000. Aflatoxins: Biological significance and regulation of biosynthesis. In J. Cary, D. Bhatnagar, and J. Linz (ed.), Microbial Foodborne Disease: Mechanisms of Pathogenesis and Toxin Synthesis. Technomic Publishing, Lancaster, Pa.
10. Cleveland, T. E., A. R. Lax, L. S. Lee, and D. Bhatnagar. 1987. Appearance of enzyme activities catalyzing conversion of sterigmatocystin to aflatoxin B1 in late-growth-phase Aspergillus parasiticus cultures. Appl. Environ. Microbiol. 53:1711-1713.
11. Eaton, D. L., and J. D. Groopman (ed.). 1994. The Toxicology of Aflatoxins: Human Health, Veterinary, and Agricultural Significance. Academic Press, San Diego, Calif.
12. Gengan, R. M., A. A. Chuturgoon, D. A. Mulholland, and M. F. Dutton. 1999. Synthesis of sterigmatocystin derivatives and their biotransformation to aflatoxins by a blocked mutant of Aspergillus parasiticus. Mycopathologia 144:115-122.
13. Guzman-de-Pena, D., and J. Ruiz-Herrera. 1997. Relationship between aflatoxin biosynthesis and sporulation in Aspergillus parasiticus. Fungal Genet. Biol. 21:198-205.
14. Harris, S. D., J. L. Morrell, and J. E. Hamer. 1994. Identification and characterization of Aspergillus nidulans mutants defective in cytokinesis. Genetics 136:517-532.
15. Hicks, J. K., J.-H. Yu, N. P. Keller, and T. H. Adams. 1997. Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G protein-dependent signaling pathway. EMBO J. 16:4916-4923.
16. Keller, G.-A., S. Krisans, S. J. Gould, J. M. Sommer, C. C. Wang, W. Schliebs, W. Kunau, S. Brody, and S. Subramani. 1991. Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes, and glycosomes. J. Cell Biol. 114:893-904.
17. Keller, N. P., H. C. Dischinger, Jr., D. Bhatnagar, T. E. Cleveland, and A. H. J. Ullah. 1993. Purification of a 40-kDa methyltransferase activity in the aflatoxin biosynthetic pathway. Appl. Environ. Microbiol. 59:479-484.
18. Liang, S.-H., C. D. Skory, and J. E. Linz. 1996. Characterization of the function of the ver-1 and ver-1B genes, involved in aflatoxin biosynthesis in Aspergillus parasiticus. Appl. Environ. Microbiol. 62:4568-4575.
19. Liang, S.-H., T.-S. Wu, R. Lee, F. S. Chu, and J. E. Linz. 1997. Analysis of mechanism regulating expression of the ver-1 gene, involved in aflatoxin biosynthesis. Appl. Environ. Microbiol. 63:1058-1065.
20. Liu, B. H., N. P. Keller, D. Bhatnagar, T. E. Cleveland, and F. S. Chu. 1993. Production and characterization of antibodies against sterigmatocystin O-methyltransferase. Food Agric. Immunol. 5:155-164.
21. Markham, P. 1995. Organelles of filamentous fungi, p. 75-98. In N. A. R. Gow and G. W. Gooday (ed.), The Growing Fungus, 1st Ed. Chapman & Hall, London, United Kingdom.
22. Meyers, D. M., G. Obrian, W. L. Du, D. Bhatnagar, and G. A. Payne. 1998. Characterization of aflJ, a gene required for conversion of pathway interme: Diates to aflatoxin. Appl. Environ. Microbiol. 64:3713-3717.
23. Mito, R. E., and C. A. Townsend. 1997. Enzymology and molecular biology of aflatoxin biosynthesis. Chem. Rev. 97:2537-2555.
24. Motomura, M., N. Chihaya, T. Shinozawa, T. Hamasaki, and K. Yabe. 1999. Cloning and characterization of the O-methyltransferase I gene (dmtA) from Aspergillus parasiticus associated with the conversion of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin in aflatoxin biosynthesis. Appl. Environ. Microbiol. 65:4987-4994.
25. Muller, W. H., T. P. van der Krift, A. J. J. Krouwer, H. A. B. Wosten, L. H. M. van der Voort, E. B. Smaal, and A. J. Verkleij. 1991. Localization of the pathway of the penicillin biosynthesis in Penicillium chrysogenum. EMBO J. 10:489-495.
26. Payne, G. A., and M. P. Brown. 1998. Genetics and physiology of aflatoxin biosynthesis. Annu. Rev. Phytopathol. 36:329-362.
27. Reichard, U., G. T. Cole, T. W. Hill, R. Ruchel, and M. Monod. 2000. Molecular characterization and influence on fungal development of ALP2, a novel serine proteinase from Aspergillus fumigatus. Int. J. Med. Microbiol. 290:549-558.
28. Skory, C. D., J. S. Horng, J. J. Pestka, and J. E. Linz. 1990. Transformation of Aspergillus parasiticus with the homologous gene (pyrG) involved in pyrimidine biosynthesis. Appl. Environ. Microbiol. 56:3315-3320.
29. Skory, C. D., P.-K. Chang, J. Cary, and J. E. Linz. 1992. Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis. Appl. Environ. Microbiol. 58:3527-3537.
30. Sweeney, M. J., and A. D. W. Dobson. 1999. Molecular biology of mycotoxin biosynthesis. FEMS Micobiol. Lett. 175:149-163.
31. Trail, F., P.-K. Chang, J. Cary, and J. E. Linz. 1994. Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxin by Aspergillus parasiticus. Appl. Environ. Microbiol. 60:3315-3320.
32. Valenciano, S., J. R. De Lucas, I. Van der Klei, M. Veenhuis, and F. Laborda. 1998. Characterization of Aspergillus nidulans peroxisomes by immunoelectron microscopy. Arch. Microbiol. 170:370-376.
33. Yu, J., J. W. Cary, D. Bhatnagar, T. E. Cleveland, N. P. Keller, and F. S. Chu. 1993. Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis. Appl. Environ. Microbiol. 59:3564-3571.
34. Yu, J., P.-K. Chang, J. W. Cary, M. Wright, D. Bhatnagar, T. E. Cleveland, G. A. Payne, and J. E. Linz. 1995. Comparative mapping of aflatoxin pathway gene clusters in Aspergillus parasiticus and Aspergillus flavus. Appl. Environ. Microbiol. 61:2365-2371.
35. Zhou, R. 1997. The Function, Accumulation, and Localization of the Nor-1 Protein Involved in Aflatoxin Biosynthesis; the Function of the fluP Gene Associated with Sporulation in Aspergillus Parasiticus. Ph.D. dissertation. Michigan State University, East Lansing.