Lateral diffusion of cholesterol and dimyristoylphosphatidylcholine in a lipid bilayer measured by pulsed field gradient NMR spectroscopy

Biophysical Journal

Volumn 83, Issue 5, 2002, Pages 2702-2704

  Orädd, Greger ^a   Lindblom, Göran ^a   Westerman, Philip W ^b  

^a UMEÅ UNIVERSITY   (Sweden)

^b NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DIMYRISTOYLPHOSPHATIDYLCHOLINE; PHOSPHOLIPID; WATER; LIPID;

ARTICLE; DIFFUSION COEFFICIENT; ENERGY; LIPID BILAYER; MAGNETIC FIELD; MEMBRANE TRANSPORT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; TEMPERATURE; BIOPHYSICS; CHEMISTRY; DIFFUSION;

BIOPHYSICS; CHOLESTEROL; DIFFUSION; DIMYRISTOYLPHOSPHATIDYLCHOLINE; LIPID BILAYERS; LIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; TEMPERATURE;

EID: 0036840281     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(02)75279-X     Document Type: Article

References (19)

1. Andersson, R. G. W. 1998. The caveolae membrane system. Annu. Rev. Biochem. 67:199-225.
2. Anderson, T. G., and H. M. McConnell. 2001. Condensed complexes and the calorimetry of cholesterol-phospholipid bilayers. Biophys. J. 81:2774-2785.
3. Cullis, P. R. 1996. Lateral diffusion rates of phosphatidylcholine in vesicle membranes: Effects of cholesterol and hydrocarbon phase transition. FEBS Lett. 70:223-228.
4. Eriksson, P. O., and G. Lindblom. 1993. Lipid and water diffusion in bicontinuous cubic phases measured by NMR. Biophys. J. 64:129-136.
5. Gustavsson, J., S. Parpal, M. Karlsson, C. Ramsing, H. Thorn, M. Borg, M. Lindroth, K. Holmgren Peterson, K.-E. Magnusson, and P. Strålfors. 1999. Localization of the insulin receptor in caveolae of adipocyte plasma membrane. FASEB J. 13:1961-1971.
6. Kauffman, J. M., P. W. Westerman, and M. C. Carey. 2000. Fluorocholesterols, in contrast to hydroxycholesterols, exhibit interfacial properties similar to cholesterol. J. Lipid Res. 41:991-1003.
7. Kuo, A. L., and C. G. Wade. 1979. Lipid lateral diffusion by pulsed nuclear magnetic resonance. Biochemistry. 18:2300-2308.
8. 2H NMR study of macroscopically aligned bilayer membranes containing interfacial hydroxyl residues. Biophys. J. 78:2441-2451.
9. Leathes, J. B. 1925. Role of fats in vital phenomena. Lancet. 208:853-856.
10. Lindblom, G., L. B.-Å. Johansson, and G. Arvidson. 1981. Effect of cholesterol in membranes. Pulsed nuclear magnetic resonance measurements of lipid lateral diffusion. Biochemistry. 20:2204-2207.
11. Lindblom, G., and G. Orädd. 1994. NMR studies of translational diffusion in lyotropic liquid crystals and lipid membranes. Prog. NMR Spectrosc. 26:483-515.
12. Parpal, S., M. Karlsson, H. Thorn, and P. Strälfors. 2001. Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control. J. Biol. Chem. 276:9670-9678.
13. Radhakrishnan, A., and H. M. McConnell. 2000. Chemical activity of cholesterol in membranes. Biochemistry. 39:8119-8124.
14. Radhakrishnan, A., and H. M. McConnell. 2002. Thermal dissociation of condensed complexes of cholesterol and phospholipid. J. Phys. Chem. B. 106:4755-4762.
15. Rubenstein, J. L. R., B. A. Smith, and H. M. McConnell. 1979. Lateral diffusion in binary mixtures of cholesterol and phosphatidylcholines. Proc. Natl. Acad. Sci. U.S.A.. 76:15-18.
16. Simons, K., and E. Ikonen. 1997. Functional rafts in cell membranes. Nature. 387:569-572.
17. Stejskal, E. O., and J. E. Tanner. 1965. Spin diffusion measurements: Spin echoes in the presence of a time-dependent field gradient. J. Chem. Phys. 42:288-292.
18. Tanner, J. E. 1970. Use of the stimulated echo in NMR diffusion studies. J. Chem. Phys. 52:2523-2526.
19. Vaz, W. L. C., K. Jacobson, E. S. Wu, and Z. Derzko. 1979. Lateral mobility of an amphipathic apolipoprotein. ApoC-III, bound to phosphatidylcholine bilayers with and without cholesterol. Proc. Natl. Acad. Sci. U.S.A. 76:5645-5649.