Intravenous dipyridamole enhances the effects of inhaled nitric oxide and prevents rebound pulmonary hypertension in piglets

Pediatric Research

Volumn 52, Issue 5, 2002, Pages 730-736

  Foubert, Luc ^a   De Wolf, Daniël ^a   Mareels, Katty ^a   Van Belleghem, Yves ^a   Reyntjens, Koen ^a   Mortier, Eric ^a   Van Nooten, Guido ^a  

^a OLV HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CYCLIC GMP; DIPYRIDAMOLE; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; THROMBOXANE A2 RECEPTOR STIMULATING AGENT;

ACUTE DISEASE; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENTIATION; DRUG RESPONSE; EVALUATION; HEART AFTERLOAD; HEART OUTPUT; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE FAILURE; HEMODYNAMICS; LOW DRUG DOSE; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PULMONARY HYPERTENSION; REBOUND PULMONARY HYPERTENSION; SWINE; SYSTEMIC CIRCULATION;

EID: 0036840061     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200211000-00020     Document Type: Article

References (36)

1. Furchgott RF, Zawadski JV 1980 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature 288:373-376
2. Moncada S, Higgs EA, Hodson HF, Knowles RG, Lopez-Jaramillo P, McCall T, Palmer RMJ, Radomski MW, Rees DD, Schultz R 1991 The L-arginine:nitric oxide pathway. J Cardiovasc Pharmacol 17(suppl 3):1-9
3. Arnold WP, Mittal CK, Katsuki S, Murad F 1977 Nitric oxide activates guanylate cyclase and increases guanosine 3′ 5′ -cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci U S A 74:3203-3207
4. Thomas MK, Sharron HF, Corbin JD 1990 Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase. J Biol Chem 265:14964-14970
5. Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, Stone D, Wallwork J 1991 Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension, Lancet 338:1173-1174
6. Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM 1991 Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 83:2038-2047
7. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM 1993 Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328:399-405
8. Kinsella JP, Neish SR, Ivy DD, Shaffer E, Abman SH 1993 Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide. J Pediatr 123:103-108
9. Wessel DL, Adatia I, Giglia TM, Thompson JE, Kulik TJ 1993 Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass. Circulation 88:2128-2138
10. Roberts JD, Lang P, Bigatello LM, Vlahakes GJ, Zapol WM 1993 Inhaled nitric oxide in congenital heart disease. Circulation 87:447-453
11. 1988 NIOSH recommendations for occupational safety and health standards 1988. MMWR Morb Mortal Wkly Rep 37(suppl 7):1-29
12. Atz AM, Adatia I, Wessel DL 1996 Rebound pulmonary hypertension after inhalation of nitric oxide. Ann Thorac Surg 62:1759-1764
13. Lavoie A, Hall JB, Olson DM, Wylam ME 1996 Life-threatening effects of discontinuing inhaled nitric oxide in severe respiratory failure. Am J Respir Crit Care Med 153:1985-1987
14. Braner DAV, Fineman JR, Chang R, Soifer SJ 1993 M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs. Am J Physiol 264:H252-H258
15. Ziegler JW, Ivy DD, Fox JJ, Kinsella JP, Clarke WR, Abman SH 1995 Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus. Am J Physiol 269:H473-H479
16. Cohen AH, Hanson K, Morris K, Fouty B, Mc Murty IF, Clarke W, Rodman DM 1996 Inhibition of cyclic 3′ - 5′ - guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats, J Clin Invest 97:172-179
17. Stamler JS, Loh E, Roddy MA, Currie KE, Creager MA 1994 Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89:2035-2040
18. Celermajer DS, Dollery C, Burch M, Deanfield JE 1994 Role of endothelium in the maintenance of low pulmonary vascular tone in normal children. Circulation 89:2041-2044
19. Giaid A, Saleh D 1995 Reduced expression of enclothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension, N Engl J Med 333:214-221
20. Bauer MA, Utell MJ, Morrow PE, Speers DM, Gibb FR 1986 Inhalation of 0.30 ppm nitrogen dioxide potentiates exercise-induced bronchospasm in asthmatics. Am Rev Respir Dis 134:1203-1208
21. Beckmann JS, Beckmann TW, Chen J, Marshall PA, Freeman BA 1990 Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 87:1620-1624
22. Thusu KG, Morin FC, Russell JA, Steinhorn RH 1995 The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide. Am J Respir Crit Care Med 152:1605-1610
23. Ichinose F, Adrie C, Hurford WE, Zapol WM 1995 Prolonged pulmonary vasodilator action of inhaled nitric oxide by zaprinast in awake lambs. J Appl Physiol 78:1288-1295
24. Wessel DL, Adatia I, Thompson JE, Hickey PR 1994 Delivery and monitoring of inhaled nitric oxide in patients with pulmonary hypertension. Crit Care Med 22:930-938
25. Foubert L, Fleming B, L'atimer RD, Jonas M, Oduro A, Borland C, Higenbottam TW 1992 Safety guidelines for use of nitric oxide. Lancet 339:1615-1616
26. Ziegler JW, Ivy DD, Wiggins JW, Kinsella JP, Clarke WR, Abman SH 1998 Effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertension. Am J Respir Crit Care Med 158:1388-1395
27. Fullerton DA, Jaggers J, Piedalue F, Grover FL, McIntyre RC 1997 Effective control of refractory pulmonary hypertension after cardiac operations. J Thorac Cardiovasc Surg 113:363-370
28. Miller OI, Tang SF, Keech A, Celermajer DS 1995 Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide. Lancet 346:51-52
29. Ivy DD, Kinsella JP, Ziegler JW, Abman SH 1998 Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease. J Thorac Cardiovasc Surg 115:875-882
30. Buga GM, Giscavage JM, Rogers NE, Ignarro LJ 1993 Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res 73:808-812
31. Oka M, Ohnishi M, Takahashi H, Soma S, Hasunuma K, Sato K, Kira S 1996 Altered vasoreactivity in lungs isolated from ras exposed to nitric oxide gas. Am J Physiol 271:L419-L424
32. Ziegler JW, Ivy DD, Fox JJ, Kinsella JP, Clarke WR, Abman SH 1998 Dipyridamole potentiates pulmonary vasodilation induced by acetylcholine and nitric oxide in the ovine fetus. Am J Respir Crit Care Med 157:1104-1110
33. Al-Alaiyan S, Al-Omran A, Dyer D 1996 The use of phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide. Intensive Care Med 22:1093-1095
34. Mosby's Complete Drug Reference 1997, 7th Ed. Mosby-Year Book, St. Louis, p II-207
35. 2 adenosine receptors in atria and aorta from the guinea pig. J Pharm Pharmacol 37:278-280
36. Atz AM, Wessel DL 1999 Sildenafil ameliorates effects of inhaled nitric oxide withdrawal. Anesthesiology 91:307-310