Serotonin receptor blockade improves distal perfusion after lower limb ischemia in the fatty Zucker rat

Cardiovascular Research

Volumn 56, Issue 2, 2002, Pages 293-302

  Janiak, Philip ^a   Lainée, Pierre ^a   Grataloup, Yoann ^a   Luyt, Charles Edouard ^b   Bidouard, Jean Pierre ^a   Michel, Jean Baptiste ^b   O'Connor, Steve E ^a   Herbert, Jean Marc ^a  

^a SANOFI   (France)

^b BICHAT HOSPITAL   (France)

Author keywords

Collateral circulation; Diabetes; Ischemia; Serotonine (5HT); Vasoconstriction dilation

Indexed keywords

MICROSPHERE; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SL 65 0472; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERY INJURY; ARTICLE; ARTIFICIAL EMBOLISM; BLOOD VESSEL REACTIVITY; CALCULATION; CONTROLLED STUDY; DIABETIC OBESITY; DOPPLER FLOWMETRY; FEMORAL ARTERY; HINDLIMB; HYPERLIPIDEMIA; ILIAC ARTERY; INTERNAL ILIAC ARTERY; LIMB ISCHEMIA; LIMB PERFUSION; MALE; MUSCLE PERFUSION; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT STRAIN; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTONINERGIC SYSTEM; SKELETAL MUSCLE; VASOCONSTRICTION; VASODILATATION;

ANIMALS; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC ANGIOPATHIES; HEMODYNAMIC PROCESSES; HINDLIMB; ILIUM; ISCHEMIA; OBESITY; OXYGEN; PARTIAL PRESSURE; PIPERAZINES; QUINOLINES; RATS; RATS, ZUCKER; REGIONAL BLOOD FLOW; SEROTONIN; SEROTONIN ANTAGONISTS; VASOCONSTRICTION;

EID: 0036839146     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00538-2     Document Type: Article

References (25)

1. European Working Group on Critical Leg Ischemia . Second European Consensus Document on chronic critical leg ischemia. Circulation. 84:(Suppl IV):1991;1-26.
2. Verheyen A., Lauwers F., Vlaminckx E., Wouters L., de Clerk F. Oversensitivity to serotonin of the collateralized vascular bed in rat hindquarters: mechanisms of increased vasoconstriction. Eur J Pharmacol. 194:1991;209-216.
3. Hollenberg N.K. Collateral arterial growth and reactivity: lessons from the limb and renal blood supply. Shaper W., Shaper J., Collateral Circulation. 1992;1-15 Kluwer, Boston, MA.
4. Loots W., De Clerck F. 5-Hydroxytryptamine dominates over thromboxane A2 in reducing collateral blood flow by activated platelets. Am J Physiol. 265:1993;H158-H164.
5. Bauters C., Asahara T., Zheng L., et al. Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor. Circulation. 91:1995;2802-2809.
6. Barrabas M.A., Gill D.S., Fonseca V.A., Mikhailidis D.P., Dandona P. Intraplatelet serotonin in patients with diabetes mellitus and peripheral vascular disease. Eur J Clin Invest. 18:1988;399-404.
7. Malyszko J., Urano T., Knofler R., et al. Daily variations of platelets aggregation in relation to blood and plasma serotonin in diabetes. Thromb Res. 75:1994;569-576.
8. McFadden E.P., Bauters C., Lablanche J.M., et al. Effect of ketanserin on proximal and distal coronary constrictor responses to intracoronary infusion of serotonin in patients with stable angina, patients with variant angina and control patients. Circulation. 86:1992;187-195.
9. 1D receptors. Circulation. 90:1994;1141-1153.
10. Kadokami T., Egashira K., Kuwata K., et al. Altered serotonin receptor subtypes mediate coronary microvascular hyperreactivity in pigs with chronic inhibition of nitric oxide synthesis. Circulation. 94:1996;1822-1829.
11. Galzin A.M., Delahaye M., Hoornaert C., McCort G., O'Connor S.E. Effects of SL65.0472, a novel 5-HT receptor antagonist, on 5-HT receptor mediated vascular contraction. Eur J Pharmacol. 404:(3):2000;361-368.
12. O'Connor S.E., Grosset A., Drieu La Rochelle C., et al. Cardiovascular effects of SL65.0472, a 5-HT receptor antagonist. Eur J Pharmacol. 414:2001;259-269.
13. Luyt C.E., Lepailleur-Enouf D., Gaultier C.J., et al. Involvement of the endothelin system in experimental critical hind limb ischemia. Mol Med. 6:(11):2000;947-956.
14. Challiss D., Hayes D., Petty R.F.H., Radda G.K. An investigation of arterial insufficiency in the rat hindlimb: a combined 31P-NMR and blood flow study. Biochem J. 236:1986;461-467.
15. Seifert F.C., Banker M., Lane B., Bagge U., Anagnostopoulos C.E. An evaluation of resting arterial ischemic models in the rat hindlimb. J Cardiovasc Surg. 26:1985;502-508.
16. Couffinhal T., Silver M., Zheng L.P., et al. Animal model: mouse model of angiogenesis. Am J Pathol. 152:1998;1667-1679.
17. Chomczynzki P., Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
18. Fowkes F.G.R., Housley E., Cawood E.H.H., et al. Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population. Int J Epidemiol. 20:1991;384-392.
19. Rivard A. Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF. Am J Pathol. 154:1999;355-363.
20. Berry C., Lorrain J., Lochot S., et al. Antiplatelet and antithrombotic activity of SL65.0472, a mixed 5-HT1B/5-HT2A receptor antagonist. Thromb Haemost. 85:2001;521-528.
21. Chleboun J.O., Martins R.N. The development and enhancement of the collateral circulation in an animal model of lower limb ischemia. Aust NZ Surg. 64:1994;202-207.
22. Frisbee J.C. Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats. Am J Physiol. 281:2001;H1568-H1574.
23. Janicek M.J., Meyerovitz M., Harrington D.P., Hollenberg N.K. Arterial response to ketanserin and aspirin in patients with advanced peripheral atherosclerosis. Invest Radiol. 27:1992;415-421.
24. Tanaka T., Fujita M., Nakae I., et al. Improvement of exercise capacity by sarpogrelate as a result of augmented collateral circulation in patients with effort angina. J Am Coll Cardiol. 32:1998;1982-1986.
25. Komiyama T., Kihara H., Hirose K., et al. Serotonin 2A receptor antagonist improves oxygen resaturation of ischaemic calf muscle in hypercholesterolemia. Eur Heart J. 22:2001;404.