Sleep and the endocrine system: New associations to old diseases

Current Opinion in Pulmonary Medicine

Volumn 8, Issue 6, 2002, Pages 502-505

  Boethel, Carl D ^a  

^a MN 614 UKMC ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFECTIVE NEUROSIS; AMNESIA; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; DROWSINESS; ENDOCRINE SYSTEM; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HORMONAL REGULATION; HUMAN; IMPOTENCE; INSULIN RESISTANCE; METABOLIC REGULATION; OBESITY; REVIEW; SLEEP; SLEEP APNEA SYNDROME; SLEEP DEPRIVATION; SLEEP DISORDER; SNORING; TRAFFIC ACCIDENT;

DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN RESISTANCE; RISK FACTORS; SLEEP APNEA, OBSTRUCTIVE; SLEEP DISORDERS;

EID: 0036839059     PISSN: 10705287     EISSN: None     Source Type: Journal    
DOI: 10.1097/00063198-200211000-00003     Document Type: Review

References (17)

1. Fester D: Diabetes mellitus. In Harrison's Principles of Internal Medicine, Edn 14. Edited by Fauci A, Braunwald E, Isselbacher K, Wilson J, et al. New York: McGraw-Hill; 1998:2060-2080.
2. Bassiri A, Guilleminault C: Clinical features and evaluation of obstructive sleep apnea-hypopnea syndrome. In Principles and Practice of Sleep Medicine, Edn 3. Edited by Kryger M, Roth T, Dement, Wm. Philadelphia: W.B. Saunders Company; 2000:869-878.
3. Spiegel K, Leproult R, Van Cauter E: Impact of sleep debt on metabolic and endocrine function. The Lancet 1999, 354:1435-1439.
4. Elmasry A, Janson C, Lindberg E, et al.: The role of habitual snoring and obesity in the development of diabetes: A 10-year follow-up study in a male population. J Intern Med 2000, 248:13-20.
5. Elmasry A, Lindberg E, Berne C, et al.: Sleep-disordered breathing and glucose metabolism in hypertensive men: A population based study. J Intern Med 2001, 249:153-161. The authors used a large patient population and long-term follow-up to investigate these patients.
6. Vgontzas A, Legro R, Bixler E, et al.: Polycystic ovarian syndrome is associated with obstructive sleep apnea and daytime sleepiness: Role of insulin resistance. J Clin Endocrinol Metab 2001, 86:517-520. Though this study focused on a small group of patients, it dealt with a group that is at risk for both diseases. The authors were able to control for obesity and, thus, investigate the effects of obstructive sleep apnea and its relation to insulin resistance.
7. Punjabi N, Sorkin J, Katzel L, et al.: Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 2002, 165:677-682. The most striking point to this study was that the degree of desaturation correlated with worsening insulin resistance. This may lead to investigations into the effect of hypoxia on the endocrine system.
8. Ip M, Lam B, Ng M, et al.: Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 2002, 165:670-676. This investigation found a correlation between number of respiratory events and the degree of insulin resistance.
9. Al-Delaimy W, Manson J, Willett W, et al.: Snoring as a risk factor for type 2 diabetes mellitus: A prospective study. Am J Epidemiol 2002, 155:387-393. This was a large epidemiologic study of women. The assumption that snoring precedes or is associated with sleep apnea is important to this study. The authors do not assume that all of these snorers are sleep apneics, but given that sleep disordered breathing is almost always associated with snoring, snorers may be at greater risk of not only sleep apnea but also diabetes mellitus.
10. Mander BA, Colecchia E, Spiegel K, et al.: Short sleep: A risk factor for insulin resistance and obesity [abstract]. Sleep 2001, 24:A74-A75. This was a well-designed study that found very strong evidence of a relation between sleep debt and insulin resistance.
11. Shigeta H, Shigeta M, Nakazawa A, et al.: Lifestyle, obesity, and insulin resistance. Diabetes Care 2001, 24:608.
12. Ryden AM, Knutson KL, Mander BA, et al.: Sleep in type 2 diabetes: Survey study. Sleep 2002, 25(supplement): A105-A106.
13. Takasaki, Y, Kurosaki S, Yamadera Y, et al.: The three months effects of CPAP on lipid and glucose metabolism in OSA. Am J Respir Crit Care Med 2002, 165(supplement):A233.
14. Verma RM, Chaudhry B, O'Brien A, et al.: Treatment of sleep apnea in diabetic patients does not improve glycemic control. Am J Respir Crit Care Med 2002, 165(supplement):A233.
15. Vgontzas A, Papanicolaou D, Bixler E, et al.: Sleep apnea and daytime sleepiness and fatigue: Relation to visceral obesity, insulin resistance, and hypercyrokinemia. J Clin Endocrinol Metab 2000, 85:1151-1158.
16. Tiemeir H, Pelzer E, Jonck L, et al.: Plasma catecholamines and selective slow wave sleep deprivation. Neuropsychobiology 2002, 45:81-86.
17. Wilcox I, McNamara SG, Collins FL, et al.: "Syndrome Z:" The interaction of sleep apnoea, vascular risk factors and heart disease. Thorax 1998, 53(supplement 3):S25-28.