Veno-occlusive disease of the liver after blood and marrow transplantation: Analysis of pre- and post-transplant risk factors associated with severity and results of therapy with tissue plasminogen activator

Leukemia and Lymphoma

Volumn 43, Issue 11, 2002, Pages 2099-2107

  Litzow, Mark R ^a   Repoussis, Panagiotis D ^a   Schroeder, Georgene ^a   Schembri Wismayer, David ^b   Batts, Kenneth P ^a   Anderson, Peter M ^a   Arndt, Carola A S ^a   Chen, Michael G ^a   Gastineau, Dennis A ^a   Gertz, Morie A ^a   Inwards, David J ^a   Lacy, Martha Q ^a   Tefferi, Ayalew ^a   Noël, Pierre ^c   Solberg, Lawrence A ^d   Letendre, Louis ^a   Hoagland, H Clark ^a  

^a MAYO CLINIC   (United States)

^b ROYAL BLACKBURN HOSPITAL   (United Kingdom)

^c MAYO CLINIC   (United States)

^d MAYO CLINIC   (United States)

Author keywords

Blood and marrow transplantation; Risk factors; Severity; Tissue plasminogen activator; Veno occlusive disease

Indexed keywords

ACICLOVIR; ANALGESIC AGENT; ANTIBIOTIC AGENT; BILIRUBIN; CORTICOSTEROID; CREATININE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DIURETIC AGENT; HEPARIN; IMMUNOSUPPRESSIVE AGENT; METHOTREXATE; PREDNISONE; TACROLIMUS; TISSUE PLASMINOGEN ACTIVATOR; UREA;

ADOLESCENT; ADULT; ADVANCED CANCER; AGED; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BILIRUBIN BLOOD LEVEL; BLOOD TRANSFUSION; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DATA BASE; DISEASE CLASSIFICATION; DISEASE SEVERITY; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; HUMAN; HUMAN TISSUE; LIVER DYSFUNCTION; LIVER VENOOCCLUSIVE DISEASE; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; RISK FACTOR; SURVIVAL RATE; SURVIVAL TIME; TIME; TREATMENT OUTCOME; UREA BLOOD LEVEL; BLOOD; HOSPITALIZATION; LIVER FUNCTION TEST; LIVER VEIN OBSTRUCTION; MIDDLE AGED; MORTALITY; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PROGNOSIS; RETROSPECTIVE STUDY;

ADOLESCENT; ADULT; BILIRUBIN; BONE MARROW TRANSPLANTATION; FEMALE; HEPATIC VENO-OCCLUSIVE DISEASE; HUMANS; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TISSUE PLASMINOGEN ACTIVATOR; UREA;

EID: 0036838232     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819021000032962     Document Type: Article

References (36)

1. McDonald, G.B., Hinds, M.S., Fisher, L.D., Schoch, H.G., Wolford, J.L., Banaji, M., Hardin, B.J., Shulman, H.M. and Clift, R.A. (1993) "Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients", Annals of Internal Medicine 118, 255-267.
2. McDonald, G.B., Sharma, P., Matthews, D.E., Shulman, H.M. and Thomas, E.D. (1984) "Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors", Hepatology 4, 116-122.
3. Hasegawa, S., Horibe, K., Kawabe, T., Kato, K., Kojima, S., Matsuyama, T. and Hirabayashi, N. (1998) "Veno-occlusive disease of the liver after allogeneic bone marrow transplantation in children with hematologic malignancies: incidence, onset time and risk factors", Bone Marrow Transplantation 22, 1191-1197.
4. Toh, H.C., McAfee, S.L., Sackstein, R., Cox, B.F., Colby, C. and Spitzer, T.R. (1999) "Late onset veno-occlusive disease following high-dose chemotherapy and stem cell transplantation", Bone Marrow Transplantation 24, 891-895.
5. Bearman, S.I. (1995) "The syndrome of hepatic veno-occlusive disease after marrow transplantation", Blood 85, 3005-3020.
6. Shulman, H.M., McDonald, G.B., Matthews, D., Doney, K.C., Kopecky, K.J., Gauvreau, J.M. and Thomas, E.D. (1980) "An analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantation", Gastroenterology 79, 1178-1191.
7. Jones, R.J., Lee, K.S., Beschorner, W.E., Vogel, V.G., Grochow, L.B., Braine, H.G., Vogelsang, G.B., Sensenbrenner, L.L., Santos, G.W. and Saral, R. (1987) "Veno-occlusive disease of the liver following bone marrow transplantation", Transplantation 44, 778-783.
8. Blostein, M.D., Paltiel, O.B., Thibault, A. and Rybka, W.B. (1992) "A comparison of clinical criteria for the diagnosis of veno-occlusive disease of the liver after bone marrow transplantation", Bone Marrow Transplantation 10, 439-443.
9. Shulman, H.M. and Hinterberger, W. (1992) "Hepatic veno-occlusive disease-liver toxicity syndrome after bone marrow transplantation", Bone Marrow Transplantation 10, 197-214.
10. Baglin, T.P., Harper, P. and Marcus, R.E. (1990) "Veno-occlusive disease of the liver complicating ABMT successfully treated with recombinant tissue plasminogen activator (rt-PA)", Bone Marrow Transplantation 5, 439-441.
11. Bearman, S.I., Shuhart, M.C., Hinds, M.S. and McDonald, G.B. (1992) "Recombinant human tissue plasminogen activator for the treatment of established severe veno-occlusive disease of the liver after bone marrow transplantation", Blood 80, 2458-2462.
12. Ringden, O., Wennberg, L., Ericzon, B.G., Kallman, R., Astrom, M., Duraj, F., Soderdahl, G., Tyden, G. and Groth, C.G. (1992) "Alteplase for hepatic veno-occlusive disease after bone marrow transplantation" (letter), Lancet 340, 546-547.
13. Rosti, G., Bandini, G., Belardinelli, A., Calori, E., Tura, S., Gherlinzoni, F. and Miggiano, C. (1992) "Alteplase for hepatic veno-occlusive disease after bone-marrow transplantation" (letter), Lancet 339, 1481-1482.
14. Espigado, I., Rodriguez, J.M., Parody, R., Carmona, M., Digon, J. and Olloqui, E. (1995) "Reversal of severe hepatic veno-occlusive disease by combined plasma exchange and rt-PA treatment", Bone Marrow Transplantation 16, 313-316.
15. Hagglund, H., Ringden, O., Ljungman, P., Winiarski, J., Ericzon, B. and Tyden, G. (1995) "No beneficial effects, but severe side effects caused by recombinant human tissue plasminogen activator for treatment of hepatic veno-occlusive disease after allogeneic bone marrow transplantation", Transplantation Proceedings 27, 3535.
16. Goldberg, S.L., Shubert, J., Rao, A.K., Redei, I., Klumpp, T.R. and Mangan, K.F. (1996) "Treatment of hepatic veno-occlusive disease with low-dose tissue plasminogen activator: impact on coagulation profile", Bone Marrow Transplantation 18, 633-636.
17. Leahey, A.M. and Bunin, N.J. (1996) "Recombinant human tissue plasminogen activator for the treatment of severe hepatic veno-occlusive disease in pediatric bone marrow transplant patients", Bone Marrow Transplantation 17, 1101-1104.
18. Kulkarni, S., Rodriguez, M., Lafuente, A., Mateos, P., Mehta, J., Singhal, S., Saso, R., Tait, D., Treleaven, J.G. and Powles, R.L. (1999) "Recombinant tissue plasminogen activator (rtPA) for the treatment of hepatic veno-occlusive disease (VOD)", Bone Marrow Transplantation 23, 803-807.
19. Ganem, G., Saint-Marc Girardin, M.F., Kuentz, M., Cordonnier, C., Marinello, G., Teboul, C., Braconnier, F., Vernant, J.P., Dhumeaux, D. and Le Bourgeois, J.P. (1988) "Veno-occlusive disease of the liver after allogeneic bone marrow transplantation in man", International Journal of Radiation Oncology, Biology, Physics 14, 879-884.
20. Essell, J.H., Thompson, J.M., Harman, G.S., Halvorson, R.D., Snyder, M.J., Johnson, R.A. and Rubinsak, J.R. (1992) "Marked increase in veno-occlusive disease of the liver associated with methotrexate use for graft-versus-host disease prophylaxis in patients receiving busulfan/cyclophosphamide", Blood 79, 2784-2788.
21. Carreras, E., Bertz, H., Arcese, W., Vernant, J.P., Tomas, J.F., Hagglund, H., Bandini, G., Esperou, H., Russell, J., de la Rubia, J., Di Girolamo, G., Demuynck, H., Hartmann, O., Clausen, J., Ruutu, T., Leblond, V., Iriondo, A., Bosi, A., Ben-Bassat, I., Koza, V., Gratwohl, A. and Apperley, J.F. (1998) "Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party", Blood 92, 3599-3604.
22. Rozman, C., Carreras, E., Qian, C., Gale, R.P., Bortin, M.M., Rowlings, P.A., Ash, R.C., Champlin, R.E., Henslee-Downey, P.J., Herzig, R.H., Hinterberger, W., Klein, J.P., Prentice, H.G., Reiffers, J., Zwaan, F.E. and Horowitz, M.M. (1996) "Risk factors for hepatic veno-occlusive disease following HLA-identical sibling bone marrow transplants for leukemia", Bone Marrow Transplantation 17, 75-80.
23. Hagglund, H., Remberger, M., Klaesson, S., Lonnqvist, B., Ljungman, P. and Ringden, O. (1998) "Norethisterone treatment, a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation", Blood 92, 4568-4572.
24. Bearman, S.I., Anderson, G.L., Mori, M., Hinds, M.S., Shulman, H.M. and McDonald, G.B. (1993) "Veno-occlusive disease of the liver: development of a model for predicting fatal outcome after marrow transplantation", Journal of Clinical Oncology 11, 1729-1736.
25. Terra, S.G., Spitzer, T.R. and Tsunoda, S.M. (1997) "A review of tissue plasminogen activator in the treatment of veno-occlusive liver disease after bone marrow transplantation", Pharmacotherapy 17, 929-937.
26. Bearman, S.I., Lee, J.L., Baron, A.E. and McDonald, G.B. (1997) "Treatment of hepatic veno-occlusive disease with recombinant human tissue plasminogen activator and heparin in 42 marrow transplant patients", Blood 89, 1501-1506.
27. Schriber, J., Milk, B., Shaw, D., Christiansen, N., Baer, M., Slack, J., Tezcan, H., Wetzler, M. and Herzig, G. (1999) "Tissue plasminogen activator (tPA) as therapy for hepatotoxicity following bone marrow transplantation", Bone Marrow Transplantation 24, 1311-1314.
28. Richardson, P.G., Elias, A.D., Krishnan, A., Wheeler, C., Nath, R., Hoppensteadt, D., Kinchla, N.M., Neuberg, D., Waller, E.K., Antin, J.H., Soiffer, R., Vredenburgh, J., Lill, M., Woolfrey, A.E., Bearman, S.I., Iacobelli, M., Fareed, J. and Guinan, E.C. (1998) "Treatment of severe veno-occlusive disease with defibrotide: compassionate use results in response without significant toxicity in a high-risk population", Blood 92, 737-744.
29. Chopra, R., Eaton, J.D., Grassi, A., Potter, M., Shaw, B., Salat, C., Neumeister, P., Finazzi, G., Iacobelli, M., Bowyer, K., Prentice, H.G. and Barbui, T. (2000) "Defibrotide for the treatment of hepatic veno-occlusive disease: results of the European Compassionate-Use Study", British Journal of Haematology 111, 1122-1129.
30. Khoury, H., Adkins, D., Brown, R., Trinkaus, K., Vij, R., Miller, G., Goodnough, L.T. and DiPersio, J. (2000) "Does early treatment with high-dose methylprednisolone alter the course of hepatic regimen-related toxicity?", Bone Marrow Transplantation 25, 737-743.
31. Ringden, O., Remberger, M., Lehmann, S., Hentschke, P., Mattsson, J., Klaesson, S. and Aschan, J. (2000) "N-acetylcysteine for hepatic veno-occlusive disease after allogeneic stem cell transplantation", Bone Marrow Transplantation 25, 993-996.
32. Richardson, P. and Guinan, E. (1999) "The pathology, diagnosis, and treatment of hepatic veno-occlusive disease: current status and novel approaches", British Journal of Haematology 107, 485-493.
33. Azoulay, D., Castaing, D., Lemoine, A., Hargreaves, G.M. and Bismuth, H. (2000) "Transjugular intrahepatic portosystemic shunt (TIPS) for severe veno-occlusive disease of the liver following bone marrow transplantation", Bone Marrow Transplantation 25, 987-992.
34. Or, R., Nagler, A., Shpilberg, O., Elad, S., Naparstek, E., Kapelushnik, J., Cass, Y., Gillis, S., Chetrit, A., Slavin, S. and Eldor, A. (1996) "Low molecular weight heparin for the prevention of veno-occlusive disease of the liver in bone marrow transplantation patients", Transplantation 61, 1067-1071.
35. Essell, J.H., Schroeder, M.T., Harman, G.S., Halvorson, R., Lew, V., Callander, N., Snyder, M., Lewis, S.K., Allerton, J.P. and Thompson, J.M. (1998) "Ursodiol prophylaxis against hepatic complications of allogeneic bone marrow transplantation. A randomized, double-blind, placebo-controlled trial", Annals of Internal Medicine 128, 975-981.
36. Ohashi, K., Tanabe, J., Watanabe, R., Tanaka, T., Sakamaki, H., Maruta, A., Okamoto, S., Aotsuka, N., Saito, K., Nishimura, M., Oh, H., Matsuzaki, M., Takahashi, S. and Yonekura, S. (2000) "The Japanese multicenter open randomized trial of ursodeoxycholic acid prophylaxis for hepatic veno-occlusive disease after stem cell transplantation", American Journal of Hematology 64, 32-38.