Discovery and development of a new insulin sensitizing agent, pioglitazone

Yakugaku Zasshi

Volumn 122, Issue 11, 2002, Pages 909-918

  Sohda, Takashi ^a   Kawamatsu, Yutaka ^b   Fujita, Takeshi ^c   Meguro, Kanji ^d   Ikeda, Hitoshi ^e  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Senjyu Pharmaceutical Company Limited   (Japan)

^c Osaka TLO   (Japan)

^d Technology Department / Yonezawa Hamari Chemicals Ltd 2 4300 18   (Japan)

^e Maruishi Pharmaceutical Co Ltd   (Japan)

Author keywords

2,4 thiazolidinedione; Hypoglycemic activity; Insulin resistance; Pioglitazone; Type II diabetes

Indexed keywords

2 CHLORO 3 [4 (2 METHYL 2 PHENYLPROPOXY)PHENYL]PROPIONIC ACID ETHYL ESTER; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL] BENZAMIDE; 5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL]BENZAMIDE; AL 321; CIGLITAZONE; GLUCOSE; INSULIN; INSULIN SENSITIZING AGENT; MURAGLITAZAR; NETOGLITAZONE; PIOGLITAZONE; RAGAGLITAZAR; REGLITAZAR; TESAGLITAZAR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE; 2,4-THIAZOLIDINEDIONE; ANTIDIABETIC AGENT; CLOFIBRATE; DRUG DERIVATIVE; THIAZOLE DERIVATIVE;

CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MARKETING; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; REVIEW; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; CLINICAL TRIAL; DIABETES MELLITUS; DRUG DESIGN; EXPERIMENTAL DIABETES MELLITUS; MOUSE; PATHOPHYSIOLOGY;

ANIMALS; CLINICAL TRIALS; CLOFIBRATE; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; DRUG DESIGN; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MICE; THIAZOLES; THIAZOLIDINEDIONES;

EID: 0036834285     PISSN: 00316903     EISSN: None     Source Type: Journal    
DOI: 10.1248/yakushi.122.909     Document Type: Review

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