Efficacy of a New Pattern of Delivery of Methylphenidate for the Treatment of ADHD: Effects on Activity Level in the Classroom and on the Playground

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 41, Issue 11, 2002, Pages 1306-1314

  Swanson, James M ^a   Gupta, Suneel ^b   Williams, Lillie ^a   Agler, Dave ^a   Lerner, Marc ^a   Wigal, Sharon ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ALZA CORPORATION   (United States)

Author keywords

Activity; Attention deficit hyperactivity disorder; Classroom; Methylphenidate; Playground

Indexed keywords

METHYLPHENIDATE; PLACEBO; RITALIN IR; CENTRAL STIMULANT AGENT;

ACTIMETRY; ARTICLE; ATTENTION; ATTENTION DEFICIT DISORDER; BOLUS INJECTION; CHILD BEHAVIOR; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; ENVIRONMENTAL FACTOR; FEMALE; HUMAN; MALE; METHODOLOGY; OUTCOMES RESEARCH; PHARMACODYNAMICS; PHARMACOKINETICS; PLAY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCHOOL; SCHOOL CHILD; SCORING SYSTEM; SUSTAINED DRUG RELEASE; TABLET; CHILD; DRUG ADMINISTRATION; RECREATION; SOCIAL ENVIRONMENT; TREATMENT OUTCOME;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; MALE; METHYLPHENIDATE; PLAY AND PLAYTHINGS; SOCIAL ENVIRONMENT; TREATMENT OUTCOME;

EID: 0036832631     PISSN: 08908567     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004583-200211000-00011     Document Type: Article

References (24)

1. Dane AV, Schachar RJ, Tannock R (2000), Does actigraphy differentiate ADHD subtypes in a clinical research setting? J Am Acad Child Adolesc Psychiatry 39:752-760
2. Greenhill LL, Abikoff HB, Arnold LE et al. (1996), Medication treatment strategies in the MTA study: relevance to clinicians and researchers. J Am Acad Child Adolesc Psychiatry 35:1304-1313
3. Greenhill LL, Swanson JM, Vitello B et al. (2001), Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial. J Am Acad Child Adolesc Psychiatry 40:180-187
4. Gualtieri CT, Hicks RE (1985), Neuropharmacology of methylphenidate and a neural substrate for childhood hyperactivity. Psychiatr Clin North Am 8:875-892
5. Kazlausky T (2000), Reducing Hyperactivity With a Feedback Actigraph. Final Report for NIMH Small Business Research Grant 1 R43 MH5803801. Ardsley, NY: Ambulatory Monitoring
6. Kent JD, Blader JC, Koplewicz HS, Abikoff H, Foley CA (1995), Effects of late-afternoon methylphenidate administration on behavior and sleep in attention-deficit hyperactivity disorder. Pediatrics 96:320-325
7. Mattay VS, Berman KF, Ostrem JL et al. (1996), Dextroamphetamine enhances "neural network-specific" physiological signals: a positron-emission tomography rCBF study. J Neurosci 16:4816-4822
8. Morton J, Frith U (1995), Causal modeling: a structural approach to developmental psychopathology. In: Manual of Developmental Psychopathology, Vol 1, Cicchetti D, Cohen D, eds. New York: Wiley, pp 357-390
9. MTA Cooperative Group (1999a), A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 56:1073-1086
10. MTA Cooperative Group (1999b), Moderators and mediators of treatment response for children with attention-deficit/hyperactivity disorder: the Multimodal Treatment Study of Children With Attention-Deficit/Hyperactivity Disorder. Arch Gen Psychiatry 56:1088-1096
11. Panksepp J (1998), Affective Neuroscience: The Foundations of Human and Animal Emotions. New York: Oxford University Press
12. Patrick KS, Muellar RA, Gualtieri CT, Breese GR (1987), Pharmacokinetics and actions of methylphenidate. In: Psychopharmacology: The Third Generation of Progress, Meltzer HY, ed. New York: Raven, pp 1387-1395
13. Porrino LJ, Rapoport JL, Behar D, Ismond DR, Bunney WE (1983), A naturalistic assessment of the motor activity of hyperactive boys, II: stimulant drug effects. Arch Gen Psychiatry 40:688-693
14. Posner MI, DiGirolamo GJ (1998), Executive attention: conflict, target detection, and cognitive control. In: The Attentive Brain, Parasuraman R, ed. Boston: MIT Press, pp 401-423
15. Posner MI, Raichle ME (1994), Images of Mind. New York: Scientific American Library
16. Sonuga-Barke EJ, Williams E, Hall M, Saxton T (1996), Hyperactivity and delay aversion, III: the effect on cognitive style of imposing delay after errors. J Child Psychol Psychiatry 37:189-194
17. Stein MA, Blondis TA, Schnitzler ER et al. (1996), Methylphenidate dosing: twice daily versus three times daily. Pediatrics 98:748-756
18. Swanson J, Gupta S, Guinta D et al. (1999a), Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children. Clin Pharmacol Ther 66:295-305
19. Swanson J, Gupta S, Lam A et al. (in press), Development of a new once-a-day formulation of methylphenidate for the treatment of ADH D: proof of concept and proof of product studies. Arch Gen Psychiatry
20. Swanson J, Posner M, Cantwell D et al. (1998), Attention-deficit/hyperactivity disorder: symptom domains, cognitive processes and neural networks. In: The Attentive Brain, Parasuraman R, ed. Boston: MIT Press, pp 445-460
21. Swanson JM, Agler D, Fineberg E et al. (1999b), The UCI Lab School Protocol for pharmacokinetic and pharmacodynamic studies In: Ritalin, 2nd ed, Greenhill L, Osman B, eds. Larchmont, NY: Mary Ann Liebert, pp 405-430
22. Volkow ND, Wang GJ, Fowler JS et al. (1998), Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry 155:1325-1331
23. Wigal SB, Gupta S, Guinta D, Swanson JM (1998), Reliability and validity of the SKAMP rating scale in a laboratory school setting. Psychopharmacol Bull 34:47-53
24. Zentall SS, Zentall TR (1976), Activity and task performance of hyperactive children as a function of environmental stimulation. J Consult Clin Psychol 44:693-697