Clinical equivalence between salbutamol hydrofluoroalkane pMDI and salbutamol Turbuhaler™ at the same cumulative microgram doses in paediatric patients

Respiratory Medicine

Volumn 96, Issue 11, 2002, Pages 957-959

  Gustafsson, P ^a   Kallman S ^a   Whitehead, P J ^b  

^a CENTRAL HOSPITAL   (Sweden)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Equivalence; Metered dose inhaler; Salbutamol; Turbuhaler

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; NORFLURANE; PLACEBO; SALBUTAMOL;

ADOLESCENT; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEVICE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; DRY POWDER; FORCED EXPIRATORY VOLUME; HEART RATE; HUMAN; INHALER; METERED DOSE INHALER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPIROMETRY;

EID: 0036828238     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1053/rmed.2002.1376     Document Type: Article

References (9)

1. Pedersen S, Moretensen S. Use of different inhalation devices in children. Lung 1990; 168 (Suppl): 653-657.
2. Thorsson L, Edsbäcker S, Conradsson TB. Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered dose inhaler (pMDI). Eur Respir J 1994; 7: 1839-1844.
3. Borgström L, Derom E, Ståhl E, Pauwels R. The inhalation device influences lung deposition of terbutaline inhaled via Turbuhaler or via a pressurized metered dose inhaler. Am J Respir Crit Care Med 1996; 153: 1636-1640.
4. Méllen A, Arvidsson P, Palmqvist M, Lötvall J. Equivalent bronchodilation with salbutamol given via pMDI or Turbuhaler. Am J Respir Crit Care Med 1999; 159: 1663-1665.
5. Arvidsson P, Méllen A, Palmqvist M, Lötvall J. Equivalent therapeutic ratio of salbutamol given by Turbuhaler® and Diskus™. Respir Med 2000; 94: 574-577.
6. Löfdahl C-G, Andesson L, Bondesson E, et al. Differences in bronchodilating potency of salbutamol in Turbuhaler as compared with a pressurized metered-dose inhaler formulation in patients with reversible airway obstruction. Eur Respir J 1997; 10: 2474-2478.
7. Carlsson L-G, Arweström E, Friberg K, Källén A, Lunde H, Löfdahl C-G. Efficacy of cumulative doses of salbutamol administered via Turbuhaler® or Diskhaler® in patients with reversible airway obstruction. Allergy 1998; 53: 712-715.
8. Prime D, Grant AC, Slater AL, Woodhouse RN. A critical comparison of the dose delivery characteristics of four alternative inhalation devices delivering salbutamol: pressurised metered dose inhaler, Diskus inhaler, Diskhaler inhaler and Turbuhaler inhaler. J Aerosol Med 1999; 12: 75-84.
9. Hirsch T, Peter-Kern M, Koch R, Leupold W. Influence of inspiratory capacity on bronchodilatation via Turbuhaler® or pressurized metered-dose inhaler in asthmatic children: a comparison. Respir Med 1997; 91: 341-346.