Preparation of 99mTc labeled substance P (SP)

Applied Radiation and Isotopes

Volumn 57, Issue 5, 2002, Pages 729-732

  Ozker, S Kutlan ^a   Hellman, Robert S ^a   Krasnow, Arthur Z ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

99mTc; Immune mediated disease; Peptides; Substance P

Indexed keywords

LIVING SYSTEMS STUDIES; PROTEINS; RADIOLOGY; TECHNETIUM; TISSUE;

DERIVATIZATION;

AMINO ACIDS;

1 IMINO 4 MERCAPTOBUTYL; CHELATING AGENT; RADIOPHARMACEUTICAL AGENT; SUBSTANCE P TECHNETIUM TC 99M; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; NEUROKININ 1 RECEPTOR; SUBSTANCE P; TECHNETIUM;

AMINO TERMINAL SEQUENCE; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DERIVATIZATION; DRUG LABELING; DRUG SYNTHESIS; IMAGING; INFLAMMATORY DISEASE; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOACTIVITY; ANIMAL; C57BL MOUSE; DRUG STABILITY; IN VITRO STUDY; MALE; METABOLISM; SALIVARY GLAND; SCINTISCANNING; SYNTHESIS;

ANIMALS; CHELATING AGENTS; DRUG STABILITY; MALE; MICE; MICE, INBRED C57BL; RADIOPHARMACEUTICALS; RECEPTORS, NEUROKININ-1; SALIVARY GLANDS; SUBSTANCE P; TECHNETIUM;

EID: 0036826928     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(02)00189-6     Document Type: Article

References (15)

1. Amartey J.K. Technetium-99m labeled somatostatin and analogs. synthesis, characterization and in vivo evaluation Nucl. Med. Biol. 20:1993;539-543.
2. Breeman W.A.P., VanHagen M.P., Visser-Wisselaar H.A., van der Pluism M.E., Koper J.W., Setyono-Han B., Bakker W.H., Kwekkeboom D.J., Hazenberg M.P., Lambers S.W.J., Visser T.J., Krenning E.P. In vitro and in vivo studies of substance P receptor expression in rats with the new analog [Indium-111-DTPA-Arg] Substance P. J. Nucl. Med. 37:1996;108-117.
3. Eckelman W.C., Steigman J. Direct labeling with Tc-99m. Nucl. Med. Biol. 18:1991;3-7.
4. Goedemans W.T., Panek K.J. A new simple method for labeling of proteins with Tc-99m. J. Nucl. Med. Allied Sci. 33:1989;286.
5. Goedemans W.T., de Jong M.T.M., Ensing G.J. 1-Imino-4-mercaptobutyl derivatization and Tc-99m-labeling of proteins. Stability of triimunoglobulin kit. Technescan HIG Eur J Nucl Med. 16:1990;450.
6. Hennig I.M., Laissue J.A., Horisberger U., Reubi J.C. Substance-P receptors in human primary neoplasms. tumoral and vascular localization Int. J. Cancer. 61:1995;786-792.
7. Joiris E., Bastin B., Thornback J.R. A new method for labeling monoclonal antibodies and their fragments with technetium-99m. Nucl. Med. Biol. 18:1991;353-356.
8. Mantyh P. Substance-P and the inflammatory and immune response. Ann. NY Acad. Sci. 632:1991;263-271.
9. Mussap C.J., Gerargthy D.P., Burcher E. Tachykinin receptors. a radioligand binding perspective. Review J. Neurochem. 60:1993;1987-2009.
10. Pallela V.R., Thakur M.L., Chakder S., Rattan S. Tc-99m-labeled vasoactive intestinal peptide receptor antagonist. functional studies J. Nucl. Med. 40:1999;352-360.
11. Payan D.G., Brewster D.R., Missirian-Bastian A., Goetzl E.J. Substance P recognition by a subset of human T lymphocytes. J. Clin. Invest. 74:1984;1532-1539.
12. 2 fragments with technetium-99m. Nucl. Med. Biol. 22:1995;451-457.
13. Walsh D.A., Mapp P.I., Wharton J., Rutherford R.A.D., Kidd .B.L., Revell .P.A., Blake D.R., Polak .J.M. Localization and characterization of substance P binding to human synovial tissue in rheumatoid arthritis. Ann. Rheum. Dis. 51:1992;513-517.
14. VanHagen P.M., Breeman .W.A.P., Reubi .J.C., Postema .P.T.E., van den Anker-Lugtenburg P.J., Kwekkeboom D.J., Laissue .J., Waser .B., Lamberts S.W.J., Visser T.J., Krenning E.P. Visualization of the thymus by substance-P receptor scintigraphy in man. Eur. J. Nucl. Med. 23:1996;1508-1513.
15. Zhang Z.M., Ballinger J.R., Sheldon K., Boxen I. Evaluation of reduction-mediated labeling of antibodies with technetium-99m. Nucl. Med. Biol. 19:1992;607-609.