Urinary elimination of cocaine metabolites in chronic cocaine users during cessation

Journal of Analytical Toxicology

Volumn 26, Issue 7, 2002, Pages 393-400

  Preston, Kenzie L ^a   Epstein, David H ^a   Cone, Edward J ^b   Wtsadik, Abraham T ^a   Huestis, Marilyn A ^a   Moolchan, Eric T ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b ConeChem Research LLC ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYLECGONINE; COCAINE; CREATININE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ELIMINATION; DRUG EXCRETION; DRUG SCREENING; DRUG URINE LEVEL; DRUG USE; DRUG WITHDRAWAL; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMAN; MALE; MICTURITION; SELF REPORT; URINALYSIS; URINARY EXCRETION;

EID: 0036825772     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/26.7.393     Document Type: Article

References (19)

1. A.J. Saxon, D.A. Calsyn, V.M. Haver, and C.J. Delaney. Clinical evaluation of urine screening for drug abuse. West. J. Med. 149: 296-303 (1988).
2. R.D. Weiss and F.H. Gawin. Protracted elimination of cocaine metabolites in long-term, high-dose cocaine abusers. Am. J. Med. 85: 879-880 (1988).
3. W.M. Burke, N.V. Ravi, B. Dhopesh Vandegrift, and I. Maany. Prolonged presence of metabolite in urine after compulsive cocaine use. J. Clin. Psychiatry 51: 145-148 (1990).
4. E.J. Cone and W.W. Weddington. Prolonged occurrence of cocaine in human saliva and urine after chronic use. J. Anal. Toxicol. 13: 65-68 (1989).
5. K.L. Preston, B.A. Goldberger, and E. Cone. Occurrence of cocaine in urine of substance-abuse treatment patients. J. Anal. Toxicol. 22: 580-586 (1998).
6. J. Ambre. The urinary excretion of cocaine and metabolites in humans: a kinetic analysis of published data. J. Anal. Toxicol. 9: 241-245 (1985).
7. E.J. Cone, K. Kumor, L.K. Thompson, and M. Sherer. Correlation of saliva cocaine levels with plasma levels and with pharmacologic effects after intravenous cocaine administration in human subjects. J. Anal. Toxicol. 12: 200-206 (1988).
8. D.S. Isenschmid, M.W. Fischman, R.W. Foltin, and Y.H. Caplan. Concentration of cocaine and metabolites in plasma of humans following intravenous administration and smoking of cocaine. J. Anal. Toxicol. 16: 311-314 (1992).
9. J.I. Javaid, M.M. Musa, M. Fischman, C.R. Schuster, and J.M. Davis. Kinetics of cocaine in humans after intravenous and intranasal administration. Biopharm. Drug Dispos. 4: 9-18 (1983).
10. A.R. Jeffcoat, M. Perez-Reyes, J.M. Hill, B.M. Sadler, and C.E. Cook. Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking. Drug Metab. Dispos. 17: 153-159 (1989).
11. E.T. Moolchan, E.A. Cone, A. Wtsadik, M.A. Huestis, and K.L. Preston. Cocaine and metabolite elimination patterns in chronic cocaine users during cessation: plasma and saliva analysis. J. Anal. Toxicol. 24: 458-466 (2000).
12. E.J. Cone, R. Lange, and W.D. Darwin. In vivo adulteration: excess fluid ingestion causes false-negative marijuana and cocaine urine test results. J. Anal. Toxicol. 22: 460-473 (1998).
13. Procedures for Transportation Workplace Drug Testing Programs, 49 C.F.R. 40, 1997.
14. M.A. Huestis and E.J. Cone. Differentiating new marijuana use from residual drug excretion in occasional marijuana users. J. Anal. Toxicol. 22: 445-454 (1998).
15. Abbott Laboratories. TDX/TDXFLX Cocaine Metabolite List No. 9670 66-7413/R2 product insert. February 1996.
16. J.M. Oyler, W.D. Darwin, K.L. Preston, P. Suess, and E.J. Cone. Cocaine disposition in meconium from newborns of cocaine-abusing mothers and urine of adult drug users. J. Anal. Toxicol. 20: 453-462 (1996).
17. J.E. Peters, J.Z. Chou, A. Ho, K. Reid, L. Borg, and M.J. Kreek. Simplified quantitation of urinary benzoylecgonine in cocaine addiction research and for related pharmacotherapeutic trials. Addiction 91: 1687-1697 (1996).
18. M.F. Boeniger, L.K. Lowry, and J. Rosenberg. Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: a review. Am. Ind. Hyg. Assoc. J. 54: 615-627 (1993).
19. K.L. Preston, K. Silverman, C.R. Schuster, and E.J. Cone. Assessment of cocaine use with quantitative urinalysis and estimation of new uses. Addiction 92: 717-727 (1997).