Risk assessment of mixtures: Possibility of prediction of interaction between chemicals

International Archives of Occupational and Environmental Health

Volumn 75, Issue SUPPL., 2002, Pages

  Tichý, Milon ^a   Borek Dohalský, Václav ^a   Rucki, Marián ^a   Reitmajer, Josef ^b   Feltl, Ladislav ^b  

^a NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Acute toxicity; Chemical mixtures; Hazard identification; Risk assessment; Worm movement inhibition

Indexed keywords

ALCOHOL; BENZENE; CHEMICAL COMPOUND;

ACUTE TOXICITY; CALCULATION; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; GAS; GAS CHROMATOGRAPHY; HAZARD ASSESSMENT; LIQUID; MODEL; NONHUMAN; PHYSICAL CHEMISTRY; PREDICTION; RISK ASSESSMENT; WORM;

TUBIFEX TUBIFEX;

EID: 0036821075     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-002-0354-0     Document Type: Conference Paper

References (21)

1. Dalton J (1889) Ueber die Absoption der Gasarten durch Wasser und andere Flüssigkeiten. In: Ostwald W (ed) Die Klassiker der Exacten Wissenschaften, No. 3 - Die Grundlagen der Atomtheorie. Verlag von Wilhelm Englemann, Leipzig, pp 3-13
2. Doull J (1988) Complex Mixtures. Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures. National Academy Press, Washington DC
3. Finney DJ (1942) The analysis of toxic tests of mixtures of poisons. Ann Appl Biol 29:82-94
4. Fredenslund FC, Nendza M, Herbst T (1995) Cosollute interactions in aqueous contaminant concentrations. SAR QSAR Environ Res 3:293-300
5. Hermens J, Broekhuyzen E, Canton H, Wegman R (1985) Quantitative structure-activity relationships and mixture toxicity studies of alcohols and cholorohydrocarbons: Effects on growth of Daphnia magna. Aquat Toxicol 6:209-217
6. Hermens J, Leeuwangh P, Musch A (1985) Joint toxicity of groups of organic aquatic pollutants to the guppy (Poecilia reticulata). Ecotoxicol Environ Saf 9:321-326
7. Hewlett PS, Plackett RL (1959) A unified theory for quantal responses to mixtures of drugs: Non-interactive action. Biometrics 15:591-610
8. Hewlett PS, Plackett RL (1979) An Introduction to the Interpretation of Quantal Responses in Biology. Edward Arnold Press, London
9. Könemann H (1981) Fish toxicity test with mixtures of more than two chemicals: A proposal for a quantitative approach and experimental results. Toxicology 19:229-238
10. Loewe S, Muischnek H (1926) Uber Kombinationswirkungen. Arch Exp Pathol Pharmakol 114:313-326
11. Martens M, Mosselmans G, Fumero S, Jacobs G, Lafontaine A (1984) Some thoughts on a possible regulatory approach at ECC level on the classification and labelling of dangerous preparations. Regul Toxicol Pharmacol 4:145-156
12. Plackett RL, Hewlett PS (1952) Quantal responses to mixtures of poisons. J R Statist Soc 14:141-163
13. Plackett RL, Hewlett PS (1967) A comparison of two approaches to the construction of models for quantal responses to mixtures of drugs. Biometrics 23:27-44
14. Poch G (1981) Quantitative estimation of potentiating or inhibitory effects of similarly acting drugs in combination. Advantages of dose-response to curve method over the isobol method. Arzneim Forsch 31:1135-1140
15. Poch G (1990) Application of the isobologram technique for the analysis of combined effects with respect to additivity as well as independence. Can J Physiol Pharmacol 68:682-688
16. Raoult FM (1887) General law of the vapor pressure of solvents (in French). C R Acad Sci III 104:1430-1433
17. Tichý M, Rucki M (1996) Alternative method for the determination of acute toxicity of chemicals: Inhibition of movements of the worms Tubifex tubifex (in Czech). Pracov Lek 48:225-230
18. Tichý M, Cikrt M, Roth Z, Rucki M (1998) QSAR anallysis in mixture toxicity assessment. SAR QSAR Environ Res 9:155-169
19. Tichý M, Borek-Dohalský V, Rucki M, Feltl L (1999) Predictive toxicology and mixtures of chemicals. In: Gini GC, Katritzky AR (eds) Predictive Toxicology of Chemicals: Experiences and Impact of Artificial Intelligence Tools. AAAI Press, Menlo Park, California, pp 152-155
20. Tichý M, Borek-Dohalský V, Rucki M (2000) Worms (Tubifex tubifex) and partition coefficients for estimation of acute toxicity. In: Balls M, van Zeller A-M, Halder ME (eds) Progress in the Reduction, Refinement and Replacement of Animal Experimentation. Elsevier Science, pp 513-520
21. Tichý M, Rucki M, Borek-Dohalksý V, Feltl L (2000) Partition coefficients of binary mixtures of chemicals: Possibility for the QSAR analysis. In: Gundertofte K, Jorgensen FS (eds) Molecular Modelling and Prediction of Bioactivity. Kluwer Academic/Plenum Publishers, New York, pp 311-313