Impact of long-term erythrocytapheresis on splenic function in patients with sickle cell disease

Journal of Pediatric Hematology/Oncology

Volumn 24, Issue 7, 2002, Pages 545-547

  Raj, Ashok ^a   Bertolone, Salvatore ^a   Klapheke, Patrick ^a   Burnett, Diane ^a   Suarez, Carlos ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Erythrocytapheresis; Hypertransfusion; Sickle cell disease; Splenic function

Indexed keywords

HEMOGLOBIN S; TECHNETIUM SULFUR COLLOID TC 99M;

ADOLESCENT; ARTICLE; BACTERIAL INFECTION; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ERYTHROCYTAPHERESIS; ERYTHROCYTE TRANSFUSION; HUMAN; LONG TERM CARE; PRIORITY JOURNAL; SICKLE CELL ANEMIA; SPLEEN FUNCTION; SPLEEN SCINTISCANNING; SPLEEN SIZE; TREATMENT INDICATION; TREATMENT OUTCOME; ULTRASOUND;

ADOLESCENT; ANEMIA, SICKLE CELL; CHILD; CHILD, PRESCHOOL; CYTAPHERESIS; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOGLOBIN, SICKLE; HUMANS; MALE; REGENERATION; SOUND SPECTROGRAPHY; SPLEEN; TIME FACTORS;

EID: 0036818037     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-200210000-00009     Document Type: Article

References (14)

1. Buchanan GR, McKee V, Jackson EA et al. Splenic phagocytic function in children with sickle cell anemia receiving long-term hypertransfusion therapy. J Pediatr 1989;115:568-72.
2. Campbell PJ, Olatunji PO, Ryan KE, et al. Splenic regrowth in sickle cell anemia following hypertransfusion. Br J Hematol 1997;96:77-9.
3. Ferster A, Bujan W, Corazza F, et al. Bone marrow transplantation corrects the splenic reticuloendothelial dysfunction in sickle cell anemia. Blood 1993;81:1102-5.
4. Claster S, Vichinsky E. First report of reversal of organ dysfunction in sickle cell anemia by the use of hydroxyurea: Splenic regeneration. Blood 1996;88:1951-3.
5. Leiken SL, Gallagher D, Kinney TR. Mortality in children and adolescents with sickle cell disease. Pediatrics 1989;84:500-8.
6. Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med 1998;339:5-11.
7. Kim HC, Dugan NP, Silber JH, et al. Erythrocytapheresis therapy to reduce iron overload in chronically transfused patients with sickle cell disease. Blood 1994;83:1136-42.
8. Valbonesi M, Bruni R. Clinical application of therapeutic erythrocytapheresis (TEA). Transfus Sci 2000;22:183-94.
9. Eckman JR. Techniques for blood administration in sickle cell patients. Semin Hematol 2001;38(Suppl 1):23-9.
10. Hilliard LM, Williams BF, Lounsbury AE, et al. Erythrocytapheresis limits iron accumulation in chronically transfused sickle cell patients. Am J Hematol 1998;59:28-35.
11. Singer ST, Quirolo K, Nishi K et al. Erythrocytapheresis for chronically transfused children with sickle cell disease: An effective method for maintaining a low hemoglobin S level and reducing iron overload. J Clin Apheresis 1999;14:122-5.
12. Cohen A, Ohene-Frempong K. Long-delayed rebirth of the spleen in sickle cell disease: Hypersplenism complicating chronic transfusion therapy [abstract]. Pediatr Res 1988;23:338A.
13. Powars D, Hiti A. Sickle cell anemia: Beta s gene cluster haplotypes as genetic markers for severe disease expression. Am J Dis Child 1993;147:1197-1202.
14. Miller ST, Sleeper LA, Pegelow CH, et al. Prediction of adverse outcomes in children with sickle cell disease. N Engl J Med 2000;342:83-9.