Thrombocytopenia and megakaryocyte dysplasia: An adverse effect of valproic acid treatment

Journal of Pediatric Hematology/Oncology

Volumn 24, Issue 7, 2002, Pages 589-590

  Gesundheit, Benjamin ^a   Kirby, Melanie ^a   Lau, Wendy ^a   Koren, Gideon ^a   Abdelhaleem, Mohamed ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

VALPROIC ACID;

ADULT; APLASTIC ANEMIA; ARTICLE; CASE REPORT; CEREBRAL PALSY; CYTOPENIA; DYSPLASIA; ERYTHROBLASTOPENIA; ERYTHROCYTE APLASIA; FEMALE; HUMAN; LEUKOCYTE DISORDER; MEGAKARYOCYTE; MEGALOCYTOSIS; MYELODYSPLASTIC SYNDROME; NEUTROPENIA; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; QUADRIPLEGIA; SEIZURE; THROMBOCYTE DYSFUNCTION; THROMBOCYTOPENIA; VON WILLEBRAND DISEASE;

BLOOD PLATELETS; BONE MARROW; CEREBRAL PALSY; CHILD; FEMALE; HUMANS; MEGAKARYOCYTES; THROMBOCYTOPENIA; VALPROIC ACID;

EID: 0036817589     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-200210000-00022     Document Type: Article

References (6)

1. Loscher W. Valproate: A reappraisal of its pharmacodynamic properties and mechanisms of action. Prog Neurobiol 1999;58:31-59.
2. Acharya S, Bussel JB. Hematologic toxicity of sodium valproate. J Pediatr Hematol Oncol 2000;22:62-5.
3. Kishi T, Fujita N, Kawaguchi H, et al. Bone marrow suppression induced by high-dose valproic acid. Arch Dis Child 1994;71:153-5.
4. Watts RG, Emanuel PD, Zuckerman KS, Howard TH. Valproic acid-induced cytopenias: Evidence for a dose-related suppression of hematopoiesis. J Pediatr 1990;117:495-9.
5. Winter SL, Kriel RL, Novacheck TF, et al. Perioperative blood loss: The effect of valproate. Pediatr Neurol 1996;15:19-22.
6. Ko CH, Kong CK, Tse PW. Valproic acid and thrombocytopenia: Cross-sectional study. Hong Kong Med J 2001;7:15-21.