Excitatory amino acid receptor blockade within the caudal pressor area and rostral ventrolateral medulla alters cardiovascular responses to nucleus raphe obscurus stimulation in rats

Brazilian Journal of Medical and Biological Research

Volumn 35, Issue 10, 2002, Pages 1237-1245

  Silva, N F ^b   Pires, J G P ^a   Dantas, M A ^a   Futuro Neto, H A ^a  

^a FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^b Instituto Superior de Educação   (Brazil)

Author keywords

Blood pressure; Caudal pressor area; Electrical stimulation; Excitatory amino acid receptors; Kynurenic acid; Raphe nuclei; Ventrolateral medulla

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; EXCITATORY AMINO ACID RECEPTOR; KYNURENIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA; ARTICLE; BLOOD PRESSURE REGULATION; BRADYCARDIA; BRAIN DEPTH STIMULATION; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; HEART RATE; HYPERTENSION; MALE; MEDULLA OBLONGATA; MICROINJECTION; NEUROMODULATION; NONHUMAN; PRESSOR RESPONSE; RAPHE NUCLEUS; RAT; RAT STRAIN; RECEPTOR BLOCKING;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0036817217     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2002001000019     Document Type: Article

References (31)

1. Adair JR, Hamilton BL, Scappaticcika KA, Helke CJ & Gillis RA (1977). Cardiovascular responses to electrical stimulation of the medullary raphe area of the cat. Brain Research, 128: 141-145.
2. Yen CT, Blum PS & Spath JA (1983). Control of cardiovascUlar function by electrical stimulation within the medullary raphe region of the cat. Experimental Neurology, 79: 666-679.
3. Futuro Neto HA, Silva SR, Dantas MA & Gilbey MP (1990). A comparison of the effects of stimulation within the raphe nuclei on arterial BP in the anesthetized rabbit and rat. Acta Physiologica et Pharmacologica Latinoamericana, 40: 175-184.
4. Faria MGC, Dantas MA & Futuro-Neto HA (1996). Pressor effects elicited by stimulation within the medullary raphe nuclei of the golden hamster (Mesocricetus auratus). Brazilian Journal of Medical and Biological Research, 29: 533-540.
5. Almada GL, Pires JGP, Dantas MA & Futuro Neto HA (1997). Pressor effects elicited by stimulation within the medullary raphe nuclei of the guinea pig (Cavia porcellus). Acta Physiologica, Pharmacologica et Therapeutica Latinoamericana, 47: 229-236.
6. Kuhn DM, Wolf WA & Lovenberg W (1980). Pressor effects of electrical stimulation of the dorsal and median raphe nuclei in anesthetized rats. Journal of Pharmacology and Experimental Therapeutics, 214: 403-409.
7. 1A receptor agonists into the raphe obscurus of the anaesthetized rat. British Journal of Pharmacology, 102: 317-322.
8. Coleman MJ & Dampney RA (1995). Powerful depressor and sympathoinhibitory effects evoked from neurons in the caudal raphe pallidus and obscurus. American Journal of Physiology, 268: R1295-R1302.
9. Amendt K, Czachurski J, Dembowsky K & Seller H (1979). Bulbospinal projections to the intermediolateral cell column: a neuroanatomical study. Journal of the Autonomic Nervous System, 1: 103-117.
10. Loewy AD (1981). Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat. Brain Research, 222: 129-133.
11. Gilbey MP, Futuro Neto HA & Zhou SY (1995). Respiratory-related discharge patterns of caudal raphe neurons projecting to the upper thoracic spinal cord in the rat. Journal of the Autonomic Nervous System, 50: 263-273.
12. Bacon SJ, Zagon A & Smith AD (1990). Electron microscopic evidence of a monosynaptic pathway between cells in the caudal raphe nuclei and sympathetic pre-ganglionic neurons in the rat spinal cord. Experimental Brain Research, 79: 589-602.
13. Zagon A (1993). Innervation of serotonergic medullary raphe neurons from cells of the rostral ventrolateral medulla in rats. Neuroscience, 55: 849-867.
14. Zagon A (1995). Internal connections in the rostral ventromedial medulla of the rat. Journal of the Autonomic Nervous System, 53: 43-56.
15. Campos Jr RR, Futuro Neto HA & Guertzenstein PG (1993). Role of the rostral ventrolateral medulla in the pressor response to stimulation of the nucleus raphe obscurus. Brazilian Journal of Medical and Biological Research, 26: 623-631.
16. Guertzenstein PG & Silver A (1974). Fall in BP produced from discrete regions of the ventral surface of the medulla by glycine and lesions. Journal of Physiology, 242: 489-503.
17. Futuro Neto HA, Dantas MA, Gilbey MP & Pires JGP (1996). A study of the nature of the projections from nucleus raphe obscurus to the ventrolateral medulla. Society for Neuroscience Abstracts, 22: 954.
18. Bisset GW, Feldberg W, Guertzenstein PG & Rocha e Silva Jr M (1975). Vasopressin release by nicotine: the site of action. British Journal of Pharmacology, 54: 463-474.
19. Feldberg W & Guertzenstein PG (1976). Vasodepressor effects obtained by drugs acting on the ventral surface of the brain stem. Journal of Physiology, 258: 337-355.
20. Cravo SL & Morrison SF (1993). The caudal ventrolateral medulla is a source of tonic sympathoinhibition. Brain Research, 621: 133-136.
21. Feldberg W & Guertzenstein PG (1986). Blood pressure effects of leptazol applied to the ventral surface of the brainstem of cats. Journal of Physiology, 372: 445-456.
22. Gordon FJ & McCann LA (1988). Pressor responses evoked by microinjections of L-glutamate into the caudal ventrolateral medulla of the rat. Brain Research, 457: 251-258.
23. Possas OS, Campos Jr RR, Cravo SL, Lopes OU & Guertzenstein PG (1994). A fall in arterial BP by blockade of the caudalmost ventrolateral medulla: the caudal pressor area. Journal of the Autonomic Nervous System, 49: 235-245.
24. Campos Jr RR, Possas OS, Cravo SL, Lopes OU & Guertzenstein PG (1994). Putative pathways involved in responses evoked from the caudal pressor area. Brazilian Journal of Medical and Biological Research, 27: 2467-2479.
25. Campos Jr RR & McAllen RM (1999). Tonic drive to sympathetic premotor neurons of rostral ventrolateral medulla from caudal pressor area neurons. American Journal of Physiology, 276: R1209-R1213.
26. Natarajan M & Morrison SF (2000). Sympathoexcitatory CVLM neurons mediate responses to caudal pressor area stimulation. American Journal of Physiology, 279: R364-R374.
27. Nicholas AP & Hancock MB (1990). Evidence for projections from the rostral medullary raphe onto medullary catecholamine neurons in the rat. Neuroscience Letters, 108: 22-28.
28. Amano M, Asari T & Kubo T (1994). Excitatory amino acid receptors in the rostro-ventrolateral medulla mediate hypertension induced by carotid body chemoreceptor stimulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 349: 549-554.
29. Koshiya N, Huangfu D & Guyenet PG (1993). Ventrolateral medulla and sympathetic chemoreflex in the rat. Brain Research, 609: 174-184.
30. Futuro Neto HA & Coote JH (1982). Desynchronised sleep-like pattern of sympathetic activity elicited by electrical stimulation of sites in the brainstem. Brain Research, 252: 269-276.
31. Silva NF, Campos Jr RR, Araujo GC, Bergamaschi CT, Pires JGP, Dantas MA & Futuro Neto HA (1998). Demonstration of projections from nucleus raphe obscurus to the caudal pressor area of the ventral medulla in the rat. Society for Neuroscience Abstracts, 24: 627.