Intention-to-treat analysis in clinical trials: Principles and practical importance;A análise de intenção-de-tratar em ensaios clínicos: Princípios e importância prática

Revista Portuguesa de Cardiologia

Volumn 21, Issue 10, 2002, Pages 1191-1198

  Soares, Isabel ^a,b   Carneiro, António Vaz ^b  

^a HOSPITAL EGAS MONIZ   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

Concealed allocation; Evidence based cardiology; Intention to treat principle; Randomization

Indexed keywords

ANALYTIC METHOD; ARTICLE; CARDIOLOGY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DATA ANALYSIS; ERROR; EVALUATION; EVIDENCE BASED MEDICINE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; THERAPY; BEHAVIOR; ETHICS; HEALTH PERSONNEL ATTITUDE; HUMAN; REVIEW;

ATTITUDE OF HEALTH PERSONNEL; CLINICAL TRIALS; HUMANS; INTENTION;

EID: 0036816739     PISSN: 08702551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Guyatt GH, Sackett DL, Cook DJ, The Evidence-Based Medicine Working Group. Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? JAMA 1993;270:2598-601.
2. Guvatt GH, Sackett DL, Cook DJ, The Evidence-Based Medicine Working Group. Users' guides to the medical literature. II. How to use an article about therapy or prevention. B. What were the results and will they help me in caring for my patients? JAMA 1994;271:59-63.
3. Soares I, Carneiro AV. Princípios de análise metodológica de ensaios terapêuticos. Parte I: Validade dos resultados. Rev Port Cardiol 2002;2113:457-69.
4. Soares I, Carneiro AV. Princípios básicos da análise metodológica de ensaios terapêuticos. Parte III: Aplicabilidade dos resultados ao doente individual. Rev Port Cardiol 2002;21:783-95.
5. Hollis S, Campbell F. What is meant by intention to treat analysis? Survey of published randomised controlled trials. BMJ 1999;319:670-4.
6. Evidence-Based Medicine. How to Practice and Teach EBM. Edinburgh: Churchill Livingstone, 2000.
7. Horwitz RI, Viscoli CM, Berkman L, Donaldson RM, Horwitz SM, Murray CJ, Ransohoff DF, Sindelar J. Treatment adherence and risk of death after a myocardial infarction. Lancet 1990;336:425-545.
8. Coronary Drug Project Research Group. Influence of adherence to treatment and response of cholesterol on mortality in the coronary drug project. N Engl J Med 1980;303:1038-41.
9. Guyatt GH, Rennie D, editors. User's Guides to the Medical Literature. A Manual for Evidence-Based Clinical Practice. Chicago: JAMA & Archives Journals AMA, 2001.
10. European Coronary Surgery Study Group. Coronary-artery bypass surgery in stable angina pectoris: Survival at two years. Lancet 1979;i:889-93.
11. Roland M, Torgerson DJ. Understanding controlled trials. What are pragmatic trials? BMJ 1998;316:285.
12. Fergusson D, Aaron SD, Guyatt G, Hébert PC. Post-randomisation exclusions: The intention to treat principle and excluding patients from analysis. BMJ 2002;325:652-4.
13. Choi SC, Lu IL. Effect of non-random missing data mechanisms in clinical trials. Stat Med 1995;14:2675-84.
14. Lewis JA, Machin D. Intention to treat - Who should use ITT? British Journal of Cancer 1993;68:647-50.