In vitro permeation screening of a new formulation of thiocolchicoside containing various enhancers

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 9, Issue 4, 2002, Pages 259-263

  Ceschel, G C ^a,c   Maffei, P ^a   Porzio, S ^b   Melillo, G ^b   Caselli, G F ^b   Dragani, M C ^b   Gentile, M M ^b   Clavenna, G ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Chemistry Section   (Italy)

^c Pharmaceutical Sciences Department   (Italy)

Author keywords

DPPG; Enhancer; Percutaneous Absorption; Thiocolchicoside

Indexed keywords

ACYLGLYCEROL; CAPSAICIN; DIETHYLENE GLYCOL MONOETHYL ETHER; LABRAFIL M1944 CS; LIPOID S20; PHOSPHATIDYLCHOLINE; PROPANEDIOL DERIVATIVE; PROPYLENE GLYCOL DIPELARGONATE; THIOCOLCHICOSIDE; UNCLASSIFIED DRUG; COLCHICINE; DRUG DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DIFFUSION; DRUG FORMULATION; DRUG PENETRATION; IN VITRO STUDY; MUSCLE SPASM; NONHUMAN; OINTMENT; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY; ANIMAL; CHEMISTRY; DIFFUSION CHAMBER; DRUG EFFECT; DRUG SCREENING; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; PERMEABILITY; SKIN; SPRAGUE DAWLEY RAT;

ADMINISTRATION, CUTANEOUS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; COLCHICINE; DIFFUSION CHAMBERS, CULTURE; DRUG EVALUATION, PRECLINICAL; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SKIN;

EID: 0036812411     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/10717540260397882     Document Type: Article

References (23)

1. Babar, A., Solanki, U. D., Cutie, A. J., and Plakogiannis, F. 1990. Piroxicam release from dermatological bases: In vitro studies using cellulose membrane and hairless mouse skin. Drug Dev. Ind. Pharm. 16:523-540.
2. Banerjee, P. S., and Ritschel, W. A. 1989. Transdermal permeation of vasopressin. II. Influence of Azone on in vitro and in vivo permeation. Int. J. Pharm. 49:199-204.
3. Barry, B. W. 1997. Mode of action of penetration enhancers in human skin. J. Contr. Rel. 6:85-97.
4. Bonina, F. P., Carelli, V., Di Colo, G., Montenegro, L., and Nannipieri, E. 1993. Vehicle effects on in vitro skin permeation of and stratum comeum affinity for model drugs caffeine and testosterone. Int. J. Pharm. 100:41-47.
5. Bonina, F. P., and Montenegro, L. 1994. Effects of some non-toxic penetration enhancer on in vitro heparin skin permeation from gel vehicles. Int. J. Pharm. 111:191-196.
6. Degim, I. T., Ulsu, A., Hadgraft, J., Atay, T., Akay, C., and Cevheroglu, S. 1999. The effects of Azone and Capsaicin on the permeation of Naproxen through human skin. Int. J. Pharm. 179:21-25.
7. Fang, J. Y., Fang, C. L., Hong, C. T., Chen, H. Y., Lin, T. Y., and Wei, H. M. 2001. Capsaicin and nonivamide as novel skin permeation enhancers for indometacin. Int. J. Pharm. 12:195-203.
8. Flynn, G. L., Yalkowsky, S. H., and Roseman, T. J. 1974. Mass transport phenomena and models: Theoretical concept. J. Pharm. Sci. 63:479-510.
9. Franz, T. J. 1975. Percutaneous absorption. On the relevance of in vitro data. J. Invest. Dermatol. 64:190-196.
10. Franz, T. J. 1983. Kinetics of cutaneous drug penetration. Int. J. Dermatol. 22:499-505.
11. Friend, D. R. 1982. In vitro skin permeation techniques. J. Contr. Rel. 18:235-248.
12. Janbroers, J. M. 1987. Review of the toxicology, pharmacodynamics and pharmacokinetics of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions. Acta Therapeutica 13:221-250.
13. Klimes, J., Sochor, J., Doleal, P., and Korner, J. 2001. HPLC evaluation of diclofenac in transdermal therapeutic preparations. Int. J. Pharm. 217:153-160.
14. Muscle relaxants. Martindale, The Complete Drug Reference, 32th Ed., 1999. 1302-1323.
15. Mura, P., Nassini, C., Valoti, M., Santoni, G., and Corti, P. 1994. The single-pass perfused rabbit ear as a model for studying percutaneous absorption of clonazepam. III. Influence of vehicle composition on drug permeation. Eur. J. Pharm. Biopharm. 40:90-95.
16. Ogiso, T., Niinaka, N., Iwaki, M., and Tanino, T. 1997. Mechanism for enhancement effect of lipid disperse system on percutaneous absorption. Int. J. Pharm. 152:135-144.
17. Reynolds, J. E. F. 1989. Muscle relaxant. In Martindale, the extra pharmacopoeia, 29th edition, 1230-1232. London: The Pharmaceutical Press.
18. Rieg-Falson, F. 1991. Taking advantage of the excipient skin partnership to the modify percutaneous absorption. B.T. Gattefosse 84:17-23.
19. Ritschel, W. A., and Hussain, A. S. 1988. Influence of selected solvents on penetration of griseofulvin in rat skin, in vitro. Pharm. Ind. 50:483-486.
20. Watkinson, A. C., Hadgraft, J., and Bye, A. 1991. Aspects of the transdermal delivery of prostaglandins. Int. J. Pharm. 74:229-236.
21. Yamane, M. A., Williams, C., and Barry, B. W. 1994. Terpene penetration enhancers in propylene glycol/water co-solvent systems: Effectiveness and mechanism of action. J. Pharm. Pharmacol. 47:978-989.
22. Yu, H. Y., and Liao, H. M. 1996. Triamcinolone permeation from different liposome formulations through rat skin in vitro. Int. J. Pharm. 127:1-7.
23. Zhang, W. Y., and Li Wan Po, A. 1994. The effectiveness of topically applied capsaicin. Eur. J. Clin. Pharmcol. 46:417-552.