Time course of action of antagonists of mitochondrial Ca uptake in intact ventricular myocytes

Pflugers Archiv European Journal of Physiology

Volumn 445, Issue 1, 2002, Pages 132-138

  Zhou, Zhuan ^a   Bers, Donald M ^b  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Biosensor; Ca uptake; Cardiac cells; CCCP; FCCP; Indo 1; Ru360; Ruthenium red

Indexed keywords

CALCIUM ANTAGONIST; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; FLUORESCENT DYE; INDO 1; RUTHENIUM RED; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; IONOPHORE; RU 360; RUTHENIUM DERIVATIVE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE; CELL STRUCTURE; CONTROLLED STUDY; ENERGY YIELD; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART VENTRICLE WALL; MEMBRANE DAMAGE; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; DRUG EFFECT; FERRET; HEART VENTRICLE; METABOLISM; TIME;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; FERRETS; HEART VENTRICLES; IONOPHORES; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; RUTHENIUM COMPOUNDS; RUTHENIUM RED; TIME FACTORS;

EID: 0036810917     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-002-0909-7     Document Type: Article

References (14)

1. Bassani JWM, Bassani RA, Bers DM (1995) Calibration of indo-1 and resting intracellular [Ca]i in intact rabbit cardiac myocytes. Biophys J 68:1453-1460
2. Bers DM (1991) Excitation-contraction Coupling and Cardiac Contractile Force. Kluwer, Dordrecht, pp:1-258
3. Gunter TE, Gunter KK, Sheu SS, Gavin CE (1994) Mitochondrial Ca transport: Physiological and pathological relevance. Am J Physiol 267:C313-C339
4. Hajnoczky G, Robb-Gaspers LD, Seitz MB, Thomas AP (1995) Decoding of cytosolic calcium oscillations in the mitochondria. Cell 82:415-24
5. Herrington J, Park YB, Babcock DF, Hille B (1996) Dominant role of mitochondria in clearance of large Ca loads from rat adrenal chromaffin cells. Neuron 16:219-228
6. Jou MJ, Peng TI, Sheu SS (1996) Histamine induced oscillation of mitochondrial free Ca concentration in single cultured brain astrocytes. J Physiol (Lond) 497:299-308
7. 2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes. J Biol Chem 273:10223-10231
8. Miyata H, Silerman HS, Sollott SJ, Lakatta EG, Stern MD, Hansford RG (1991) Measurement of mitochondrial free Ca concentration in living single rat cardiac myocytes. Am J Physiol 261:H1123-H1134
9. Rizzuto R, Simpson AW, Brini M, Pozzan T (1992) Rapid changes of mitochondrial Ca revealed by specifically targeted recombinant aequorin. Nature 358:325-327
10. Rutter GA, Theler JM, Murgia M, Wollheim CB, Pozzan T, Rizzuto R (1993) Stimulated Ca influx raises mitochondrial free Ca to supra micromolar levels in a pancreatic B-cell lines. J Biol Chem 268:22385-22395
11. Ying WL, Emerson J, Clarke MJ, Sanadi DR (1991) Inhibition of mitochondrial calcium ion transport by oxo-bridged dinuclear ruthenium amine complex. Biochemistry 30:4949-4952
12. 2+ buffers in bovine adrenal chromaffin cells. J Physiol (Lond) 469:245-273
13. Zhou Z, Neher E (1993) Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells. Pflugers Arch 425:511-517
14. 2+ signals in patch clamped mammalian ventricular myocytes. J Physiol (Lond) 507:379-403