A tryptophan residue (W736) in the amino-terminus of the P-segment of domain II is involved in pore formation in Nav1.4 voltage-gated sodium channels

Pflugers Archiv European Journal of Physiology

Volumn 445, Issue 1, 2002, Pages 18-24

  Carbonneau, Eric ^a   Vijayaragavan, Kausalia ^a   Chahine, Mohamed ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Nav1.4; Skeletal muscle; Sodium channel; Tetrodotoxin; Xenopus oocytes; Conotoxin

Indexed keywords

AMMONIA; CADMIUM; CESIUM ION; COMPLEMENTARY RNA; CONOTOXIN; CYSTEINE; LITHIUM ION; POTASSIUM ION; SODIUM CHANNEL; SODIUM ION; TETRODOTOXIN; THIOMESYLIC ACID METHYL ESTER; TRIMETHYLAMMONIUM SALT DERIVATIVE; TRYPTOPHAN; (2 (TRIMETHYLAMMONIUM)ETHYL)METHANETHIOSULFONATE; (2-(TRIMETHYLAMMONIUM)ETHYL)METHANETHIOSULFONATE; CONOTOXIN G3; ION; MESYLIC ACID DERIVATIVE; MUSCLE PROTEIN; PROTEIN SUBUNIT; SCN4A PROTEIN, RAT; THIOL REAGENT;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; FEMALE; ION TRANSPORT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; SKELETAL MUSCLE; SODIUM CURRENT; XENOPUS LAEVIS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; ELECTRIC CONDUCTIVITY; GENETICS; MUTATION; PHYSIOLOGY; RAT;

AMINO ACID SEQUENCE; ANIMALS; CADMIUM; CONOTOXINS; ELECTRIC CONDUCTIVITY; FEMALE; IONS; MESYLATES; MUSCLE PROTEINS; MUTATION; OOCYTES; PROTEIN SUBUNITS; RATS; SODIUM CHANNELS; SULFHYDRYL REAGENTS; TETRODOTOXIN; TRYPTOPHAN; XENOPUS LAEVIS;

EID: 0036810860     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-002-0887-9     Document Type: Article

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