Clinical assessment of ramosetron HCl oral preparation in the treatment of nausea and vomiting induced by cisplatin: A multicenter, randomized, parallel-design, double-blind comparative study with ondansetron HCl

Current Therapeutic Research - Clinical and Experimental

Volumn 63, Issue 10, 2002, Pages 636-648

  Noda, Kiichiro ^a   Ikeda, Masanori ^b   Taguchi, Tetsuo ^c   Kanamaru, Ryunosuke ^d   Ichijyo, Motohiko ^e   Okada, Koji ^f   Yano, Saburo ^g   Sugimoto, Osamu ^h   Fukuoka, Masahiro ⁱ   Nakashima, Mitsuyoshi ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d NARA MEDICAL UNIVERSITY HOSPITAL   (Japan)

^e Kyoto College of Medical Technology   (Japan)

^f UNIVERSITY OF TOYAMA   (Japan)

^g OSAKA MEDICAL COLLEGE   (Japan)

^h OSAKA CITY GENERAL HOSPITAL   (Japan)

ⁱ HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cisplatin; Nausea; Ondansetron; Ramosetron; Vomiting

Indexed keywords

CISPLATIN; ONDANSETRON; PLACEBO; RAMOSETRON;

ADULT; AGED; ANTIEMETIC ACTIVITY; ARTICLE; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG INHIBITION; DRUG TOLERABILITY; FEMALE; FEVER; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STATISTICAL ANALYSIS; TABLET; VOMITING;

EID: 0036809008     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(02)80068-6     Document Type: Article

References (13)

1. Coates A, Abraham S, Kaye SB, et al. On the receiving end - Patient perception of the side-effects of cancer chemotherapy. Eur J Cancer Clin Oncol. 1983;19:203-208.
2. Andrews PL, Rapeport WG, Sanger GJ. Neuropharmacology of emesis induced by anti-cancer therapy. Trends Pharmacol Sci. 1988;9:334-341.
3. Bonneterre J, Chevallier B, Metz R, et al. A randomized double-blind comparison of ondansetron and metoclopramide in the prophylaxis of emesis induced by cyclophosphamide, fluorouracil, and doxorubicin or epirubicin chemotherapy. J Clin Oncol. 1990;8:1063-1069.
4. Gebbia V, Cannata G, Testa A, et al. Ondansetron versus granisetron in the prevention of chemotherapy-induced nausea and vomiting. Cancer. 1994;74:1945-1952.
5. Marty M, Pouillart P, Scholl S, et al. Comparison of the 5-hydroxytryptamine 3 (serotonin) antagonist ondansetron (GR 38032F) with high-dose metoclopramide in the control of cisplatin-induced emesis. N Engl J Med. 1990;322:816-821.
6. Hesketh PJ, Murphy WK, Lester EP, et al. GR 38032F (GR-C507/75): A novel compound effective in the prevention of acute cisplatin-induced emesis. J Clin Oncol. 1989;7:700-705.
7. Ariyoshi Y, Ota K, Taguchi T, et al. Anti-emetic effect and safety of ondansetron tablet in double-blind comparison with placebo [in Japanese]. Jpn J Cancer Chemother. 1992;19:2057-2070.
8. 3 antagonists ramosetron and granisetron in treating acute chemotherapy-induced emesis, nausea, and anorexia: A single-blind, randomized, crossover study. Curr Ther Res Clin Exp. 2000;61:901-909.
9. 3 receptor blocking activities of YM060, a novel 4,5,6,7-tetrahydrobenzimidazole derivative, and its enantiomer in anesthetized rats. J Pharmacol Exp Ther. 1991;259:815-819.
10. 3 receptor antagonist, on cisplatin-induced emesis in the ferret. Clin Pharmacol Ther. 1996;6:1215-1220.
11. Noda K, Ikeda M, Taguchi T, et al. Late phase II clinical study of ramosetron oral formulation in the treatment of nausea and vomiting caused by cisplatin administration [in Japanese]. J New Remedies Clin. 1996;45(1):51-63.
12. Noda K, Ikeda M, Ichijyo M, et al. Early phase II clinical study of ramosetron oral formulation in the treatment of nausea and vomiting caused by cisplatin administration [in Japanese]. J New Remedies Clin. 1996;45(3):44-52.
13. Noda K, Ikeda M, Yoshida O, et al. Clinical phase III study of YM060 injection on anticancer drug, cisplatin-induced nausea and vomiting [in Japanese]. J New Remedies Clin. 1994;43(11):2241-2255.