The organization of the genes encoding the A chains of β-bungarotoxins: Evidence for the skipping of exon

Toxicon

Volumn 40, Issue 10, 2002, Pages 1437-1443

  Chu, Yuan Ping ^a   Chang, Long Sen ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Bungarotoxin; A chain; Exon skipping; Genomic structure; Signal peptide

Indexed keywords

BETA BUNGAROTOXIN; COMPLEMENTARY DNA; MESSENGER RNA; PHOSPHOLIPASE A2; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; EXON; GENE EXPRESSION; GENETIC ORGANIZATION; INTRON; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BUNGAROTOXINS; BUNGARUS; EXONS; GENOMICS; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHOLIPASES A; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, NUCLEIC ACID;

BUNGARUS FASCIATUS; BUNGARUS MULTICINCTUS; SERPENTES;

EID: 0036802716     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(02)00160-5     Document Type: Article

References (28)

1. Abe T., Alema S., Miledi R. Isolation and characterization of presynaptically acting neurotoxin from the venom of Bungarus snake. Eur. J. Biochem. 80:1977;1-12.
2. 2 in malayan spitting cobra (Naja naja sputatrix) venom. Toxicon. 15:1997;27-37.
3. Chang L.S., Wu P.F., Chang C.C. cDNA sequence analysis and expression of the A chain of β-bungarotoxin from Bungarus multicinctus (Taiwan banded krait). Biochem. Biophys. Res. Commun. 221:1996;328-332.
4. Chang L.S., Wu P.F., Chang C.C. cDNA sequence analysis and mutagenesis studies on the A chain of β-bungarotoxin from Taiwan banded krait. J. Protein Chem. 15:1996;755-761.
5. 2 from Bungarus multicinctus. Nucleic Acids Res. 18:1990;4608.
6. Danse J.M., Toussaint J.L., Kempf J. Nucleotide sequence encoding β-bungarotoxin A2 chain from the venom glands of Bungarus multicinctus. Nucleic Acids Res. 18:1990;4609.
7. Danse J.M., Garnier J.M., Kempf J. cDNA deduced amino-acid sequence of a new phospholipase from Bungarus multicinctus. Nucleic Acids Res. 18:1990;4610.
8. Harvey A.L., Anderson A.J. Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. Harvey A.L., Snake Toxins. 1991;131-164 Pergamon Press, New York.
9. 2 based upon structural determinants. J. Biol. Chem. 252:1977;4913-4921.
10. 2 gene. Mol. Biol. Evol. 17:2000;1010-1021.
11. John T.R., Smith L.A., Kaiser I.I. Genomic sequences encoding the acidic and basic subunits of mojave toxin: unusually high sequence identity of non-coding regions. Gene. 139:1994;229-234.
12. 2. Biochem. Biophys. Res. Commun. 168:1990;1059-1065.
13. 1-bungarotoxin from the venom of Bungarus multicinctus (Formosan banded krait). J. Biochem. 83:1978;91-99.
14. 1-bungarotoxin from the venom of Bungarus multicinctus. J. Biochem. 83:1978;101-115.
15. Kondo K., Toda H., Narita K., Lee C.Y. Amino acid sequence of three β-bungarotoxins (β3-, β4, and β5-bungarotoxins) from Bungarus venom. Amino acid substitutions in the A chains. J. Biochem. 91:1982;1531-1548.
16. 2 genes. Eur. J. Biochem. 240:1996;83-90.
17. 2 genes is unexpectedly limited to the third exon. Biochem. Biophys. Res. Commun. 251:1998;613-619.
18. 2. Biochim. Biophys. Acta. 1087:1990;95-97.
19. 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action. Structure. 3:1995;1109-1119.
20. 2 isozymes genes. Gene. 172:1996;267-272.
21. 2 isozyme genes. Proc. Natl. Acad. Sci. 92:1995;5605-5609.
22. Ohno M., Menez R., Ogawa T., Danse J.M., Shimohigashi Y., Fromen C., Ducancel F., Zinn-Justin S., Le Du M.H., Boulain J.C., Tamiya T., Menez A. Molecular evolution of snake toxins: is the functional diversity of snake toxins associated with a mechanism of accelerated evolution? Prog. Nucleic Acid Res. Mol. Biol. 59:1998;307-364.
23. 2 from Taiwan cobra. Biochem. Biophys. Res. Commun. 199:1994;969-976.
24. Sambrook, J., Fritsh, E.F., Maniatis, J.L., 1989. Molecular Cloning: A Laboratory Manual, second ed, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
25. Strong P.N., Goerke J., Oberg S.G., Kelly R.B. β-Bungarotoxin, a pre-synaptic toxin with enzymatic activity. Proc. Natl. Acad. Sci. 73:1976;178-182.
26. Wu P.F., Chang L.S. Genetic organization of A chain and B chain of β-bungarotoxin from Taiwan banded krait (Bungarus multicinctus). A chain genes and B chain genes do not share a common origin. Eur. J. Biochem. 267:2000;4668-4675.
27. Wu P.F., Chang L.S. Expression of A chain and B chain of β-bungarotoxin from Taiwan banded krait: the functional implication of the interchain disulfide bond between A chain and B chain. J. Protein Chem. 20:2001;413-421.
28. Wu P.F., Wu S.N., Chang C.C., Chang L.S. Cloning and functional expression of B chains of β-bungarotoxins from Bungarus multicinctus (Taiwan banded krait). Biochem. J. 334:1998;87-92.