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1
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0035873074
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3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor
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Bagnard D., Vaillant C., Khuth S.T., Dufay N., Lohrum M., Puschel A.W., Belin M.F., Bolz J., Thomasset N. 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor. J Neurosci. 15:2001;3332-3341.
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Brown C.B., Feiner L., Lu M.M., Li J., Ma X., Webber A.L., Jia L., Raper J.A., Epstein J.A. PlexinA2 and Semaphorin signaling during cardiac neural crest development. Development. 128:2001;3071-3080.
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0034839802
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Targeted disruption of Semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption
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Feiner L., Webber A.L., Brown C.B., Lu M.M., Jia L., Feinstein P., Mombaerts P., Epstein J.A., Raper J.A. Targeted disruption of Semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption. Development. 128:2000;3061-3070.
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Watanabe C., Kumanogoh A., Shi W., Suzuki K., Yamada S., Okabe M., Yoshida K., Kikutani H. Enhanced immune responses in transgenic mice expressing a truncated form of the lymphocyte Semaphorin CD100. J Immunol. 167:2001;4321-4328.
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0037133617
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Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis
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Takashima S., Kitakaze M., Asakura M., Asanuma H., Sanada S., Tashiro F., Niwa H., Miyazaki Ji J., Hirota S., Kitamura Y., et al. Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci USA. 99:2002;3657-3662.
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A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response
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Tordjman R., Lepelletier Y., Lemarchandel V., Cambot M., Gaulard P., Hermine O., Romeo P.H. A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response. Nat Immunol. 3:2002;477-482.
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Trusolino L., Comoglio P.M. Scatter-factor and Semaphorin receptors: cell signalling for invasive growth. Nature Rev Cancer. 2:2002;289-300.
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0035884808
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Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 [Ulip6/CRMP5]: Coexistence with Ulip2/CRMP2 in Sema3a-sensitive oligodendrocytes
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Ricard D., Rogemond V., Charrier E., Aguera M., Bagnard D., Belin M.F., Thomasset N., Honnorat J. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 [Ulip6/CRMP5]: coexistence with Ulip2/CRMP2 in Sema3a-sensitive oligodendrocytes. J Neurosci. 15:2001;7203-7214.
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Gavazzi I. Semaphorin-neuropilin-1 interactions in plasticity and regeneration of adult neurons. Cell Tissue Res. 305:2001;275-284.
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Liu B.P., Strittmatter S.M. Semaphorin-mediated axonal guidance via Rho-related G proteins. Curr Opin Cell Biol. 13:2001;619-626.
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Liu, B.P.1
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0037065995
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He Z, Wang KC, Koprivica V, Ming G, Song HJ: Knowing how to navigate: Mechanisms of Semaphorin signaling in the nervous system. Science's Signal Transduction Knowledge Environment 2002, http://stke.sciencemag.org/cgi/content/full/sigtrans;2002/119/re1
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He, Z.1
Wang, K.C.2
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13
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0032433853
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Protein Plexin A is a neuronal semaphorin receptor that controls axon guidance
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Weinberg M.L., Noordermeer J.N., Tamagnone L., Comoglio P.M., Spriggs M.K., Tessier-Lavigne M., Goodman C.S. Protein Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 23:1998;903-916.
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Tessier-Lavigne, M.6
Goodman, C.S.7
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14
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0033214312
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Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
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Takahashi T., Fournier A., Nakamura F., Wang L.H., Murakami Y., Kalb R.G., Fujisawa H., Strittmatter S.M. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell. 99:1999;59-69.
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Strittmatter, S.M.8
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20244364929
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Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates
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Tamagnone L., Artigiani S., Chen H., He Z., Ming G.I., Song H., Chedotal A., Winberg M.L., Goodman C.S., Poo M., et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 99:1999;71-80.
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Tamagnone, L.1
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Chedotal, A.7
Winberg, M.L.8
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16
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0032215144
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Neuropilin-2 is a receptor for semaphorin IV: Insight into the structural basis of receptor function and specificity
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Giger R.J., Urquhart E.R., Gillespie S.K., Levengood D.V., Ginty D.D., Kolodkin A.L. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Neuron. 21:1998;1079-1092.
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Giger, R.J.1
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Levengood, D.V.4
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Kolodkin, A.L.6
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17
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0032215735
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Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse
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Nakamura F., Tanaka M., Takahashi T., Kalb R.G., Strittmatter S.M. Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse. Neuron. 21:1998;1093-1100.
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(1998)
Neuron
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Nakamura, F.1
Tanaka, M.2
Takahashi, T.3
Kalb, R.G.4
Strittmatter, S.M.5
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18
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0037124068
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Characterization of neuropilin-1 structural features that confer binding to Sema3A and VEGF165
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These authors characterize the amino acid sequence of NP1 that allows interaction with two structurally distinct ligand families, the Semas and the VEGFs. Interestingly, the binding sites for Sema3A and VEGF165 map onto distinct NP1 domains. On the cell membrane, the formation of NP1 homodimers and NP1/Plex complexes also involves an amino acid sequence distinct from that forming the ligand binding sites. This is consistent with the current view that concomitant NP1/NP1, NP1/PlexA1 and NP1/Sema3A are crucial for Sema3A signaling.
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Gu C., Limberg B.J., Whitaker G.B., Perman B., Leahy D.J., Rosenbaum J.S., Ginty D.D., Kolodkin A.L. Characterization of neuropilin-1 structural features that confer binding to Sema3A and VEGF165. J Biol Chem. 277:2002;18069-18076. These authors characterize the amino acid sequence of NP1 that allows interaction with two structurally distinct ligand families, the Semas and the VEGFs. Interestingly, the binding sites for Sema3A and VEGF165 map onto distinct NP1 domains. On the cell membrane, the formation of NP1 homodimers and NP1/Plex complexes also involves an amino acid sequence distinct from that forming the ligand binding sites. This is consistent with the current view that concomitant NP1/NP1, NP1/PlexA1 and NP1/Sema3A are crucial for Sema3A signaling.
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(2002)
J Biol Chem
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Gu, C.1
Limberg, B.J.2
Whitaker, G.B.3
Perman, B.4
Leahy, D.J.5
Rosenbaum, J.S.6
Ginty, D.D.7
Kolodkin, A.L.8
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19
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0035105491
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Plexin-A1 autoinhibition by the plexin Sema domain
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Using coprecipitation experiments and deleted Plex constructs, these authors describe a mechanism for the autoinhibition of Plex activation, which is released by Sema binding. This work also reports that PlexA1 and PlexA2, when coexpressed with NPs, cause COS7 cells to contract. PlexA3, however, is inefficient in transducing the Sema signal and modulating cell morphology.
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Takahashi T., Strittmatter S.M. Plexin-A1 autoinhibition by the plexin Sema domain. Neuron. 29:2001;429-439. Using coprecipitation experiments and deleted Plex constructs, these authors describe a mechanism for the autoinhibition of Plex activation, which is released by Sema binding. This work also reports that PlexA1 and PlexA2, when coexpressed with NPs, cause COS7 cells to contract. PlexA3, however, is inefficient in transducing the Sema signal and modulating cell morphology.
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(2001)
Neuron
, vol.29
, pp. 429-439
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Takahashi, T.1
Strittmatter, S.M.2
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20
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0035950227
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Plexin-A3 mediates Semaphorin signaling and regulates the development of hippocampal axonal projections
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Here the function of PlexA3 was addressed by the generation of PlexA3 mutant mice. In cocultures of mutant dorsal root ganglia explants with Sema3A or Sema3F secreting cells, the chemorepulsive effects of Sema3F were abrogated by the invalidation of the PlexA3 gene. Sema3A only partially repelled axons from the Plex mutant, indicating that PlexA3 is required, but not sufficient for the transduction of the Sema3A signal. Similarities in the phenotypic defects observed in the PlexA3, NP and Sema3A mutants provide in vivo confirmation of PlexA3 as a component of Sema signaling.
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Cheng H.J., Bagri A., Yaron A., Stein E., Pleasure S.J., Tessier-Lavigne M. Plexin-A3 mediates Semaphorin signaling and regulates the development of hippocampal axonal projections. Neuron. 25:2001;249-263. Here the function of PlexA3 was addressed by the generation of PlexA3 mutant mice. In cocultures of mutant dorsal root ganglia explants with Sema3A or Sema3F secreting cells, the chemorepulsive effects of Sema3F were abrogated by the invalidation of the PlexA3 gene. Sema3A only partially repelled axons from the Plex mutant, indicating that PlexA3 is required, but not sufficient for the transduction of the Sema3A signal. Similarities in the phenotypic defects observed in the PlexA3, NP and Sema3A mutants provide in vivo confirmation of PlexA3 as a component of Sema signaling.
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(2001)
Neuron
, vol.25
, pp. 249-263
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Cheng, H.J.1
Bagri, A.2
Yaron, A.3
Stein, E.4
Pleasure, S.J.5
Tessier-Lavigne, M.6
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21
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0030778454
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Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice
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Kitsukawa T., Shimizu M., Sanbo M., Hirata T., Taniguchi M., Bekku Y., Yagi T., Fujisawa H. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron. 19:1997;995-1005.
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Neuron
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Kitsukawa, T.1
Shimizu, M.2
Sanbo, M.3
Hirata, T.4
Taniguchi, M.5
Bekku, Y.6
Yagi, T.7
Fujisawa, H.8
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22
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0030987542
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Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection
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Taniguchi M., Yuasa S., Fujisawa H., Naruse I., Saga S., Mishina M., Yagi T. Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron. 19:1997;519-530.
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(1997)
Neuron
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Taniguchi, M.1
Yuasa, S.2
Fujisawa, H.3
Naruse, I.4
Saga, S.5
Mishina, M.6
Yagi, T.7
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23
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0033678716
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Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance
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Castellani V., Chedotal A., Schachner M., Faivre-Sarrailh C., Rougon G. Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance. Neuron. 27:2000;237-249.
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(2000)
Neuron
, vol.27
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Castellani, V.1
Chedotal, A.2
Schachner, M.3
Faivre-Sarrailh, C.4
Rougon, G.5
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24
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0034782822
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The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance
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This study reports data obtained from biochemical and genetic screens for Plex-interacting proteins. The dTrK/Otk protein was found to associate with Plex in vitro. In vivo, dTrk/Otk loss-of-function induced guidance errors comparable to those observed in Sema1A and PlexA mutants. Interestingly, Otk loss-of-function suppressed the abnormal pattern of motoneuron innervation in muscles ectopically overexpressing Sema1A. These findings provide genetic evidence for Otk being downstream of the Sema signal.
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Winberg M.L., Tamagnone L., Bai J., Comoglio P.M., Montell D., Goodman C.S. The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance. Neuron. 32:2001;53-62. This study reports data obtained from biochemical and genetic screens for Plex-interacting proteins. The dTrK/Otk protein was found to associate with Plex in vitro. In vivo, dTrk/Otk loss-of-function induced guidance errors comparable to those observed in Sema1A and PlexA mutants. Interestingly, Otk loss-of-function suppressed the abnormal pattern of motoneuron innervation in muscles ectopically overexpressing Sema1A. These findings provide genetic evidence for Otk being downstream of the Sema signal.
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(2001)
Neuron
, vol.32
, pp. 53-62
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Winberg, M.L.1
Tamagnone, L.2
Bai, J.3
Comoglio, P.M.4
Montell, D.5
Goodman, C.S.6
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25
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0035253071
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Rho GTPases in growth cone guidance
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Dickson B.J. Rho GTPases in growth cone guidance. Curr Opin Neurobiol. 11:2001;103-110.
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(2001)
Curr Opin Neurobiol
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Dickson, B.J.1
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26
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0034191927
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Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal Semaphorin 3A
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Rohm B., Ottemeyer A., Lohrum M., Puschel A.W. Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal Semaphorin 3A. Mech Dev. 93:2000;95-104.
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(2000)
Mech Dev
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Rohm, B.1
Ottemeyer, A.2
Lohrum, M.3
Puschel, A.W.4
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27
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0034550281
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The Semaphorin 3A receptor may directly regulate the activity of small GTPases
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Rohm B., Rahim B., Kleiber B., Hovatta I., Puschel A.W. The Semaphorin 3A receptor may directly regulate the activity of small GTPases. FEBS Lett. 486:2000;68-72.
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(2000)
FEBS Lett
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Rohm, B.1
Rahim, B.2
Kleiber, B.3
Hovatta, I.4
Puschel, A.W.5
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28
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0033739987
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The Semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner
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Vikis H.G., Li W., He Z., Guan K.L. The Semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proc Natl Acad Sci USA. 97:2000;12457-12462.
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(2000)
Proc Natl Acad Sci USA
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Vikis, H.G.1
Li, W.2
He, Z.3
Guan, K.L.4
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29
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0035814887
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Plex-B Sema receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho
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Driessens M.H., Hu H., Nobes C.D., Self A., Jordens I., Goodman C.S., Hall A. Plex-B Sema receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho. Curr Biol. 11:2001;339-344.
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(2001)
Curr Biol
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, pp. 339-344
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Driessens, M.H.1
Hu, H.2
Nobes, C.D.3
Self, A.4
Jordens, I.5
Goodman, C.S.6
Hall, A.7
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30
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0034783680
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Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling
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This paper presents genetic and biochemical evidence that PlexB mediates repulsion in vivo. This is due in part to its binding to active Rac, thereby downregulating its effector output, and in part to its binding to and activation of RhoA. Removal of a copy of Rac enhanced a PlexB gain-of-function phenotype, whereas overexpression of PlexB enhanced a Rac dominant-negative phenotype in motor axon guidance. Biochemical analysis showed that PlexB binding to active Rac competes with PAK binding to active Rac in a dose-dependent fashion. See also [31••].
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Hu H., Marton T.F., Goodman C.S. Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Neuron. 32:2001;39-51. This paper presents genetic and biochemical evidence that PlexB mediates repulsion in vivo. This is due in part to its binding to active Rac, thereby downregulating its effector output, and in part to its binding to and activation of RhoA. Removal of a copy of Rac enhanced a PlexB gain-of-function phenotype, whereas overexpression of PlexB enhanced a Rac dominant-negative phenotype in motor axon guidance. Biochemical analysis showed that PlexB binding to active Rac competes with PAK binding to active Rac in a dose-dependent fashion. See also [31••] .
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(2001)
Neuron
, vol.32
, pp. 39-51
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Hu, H.1
Marton, T.F.2
Goodman, C.S.3
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31
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0036206649
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The Plex-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding
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This paper presents a biochemical analysis of PlexB repulsion using mammalian proteins and is consistent with [30••]. Binding of Sema4D to PlexB1 stimulated the recruitment of active Rac. In addition, expression of active Rac stimulated the localization of PlexB1 to the cell surface and enhanced the ability of PlexB1 to interact with Sema4D.
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Vikis H.G., Li W., Guan K.L. The Plex-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Genes Dev. 16:2002;836-845. This paper presents a biochemical analysis of PlexB repulsion using mammalian proteins and is consistent with [30••] . Binding of Sema4D to PlexB1 stimulated the recruitment of active Rac. In addition, expression of active Rac stimulated the localization of PlexB1 to the cell surface and enhanced the ability of PlexB1 to interact with Sema4D.
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(2002)
Genes Dev
, vol.16
, pp. 836-845
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Vikis, H.G.1
Li, W.2
Guan, K.L.3
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32
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0037080330
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Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Sema 3A-induced cytoskeletal collapse
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Here the authors used pull-down assays and screened a collection of GTPases to determine Plex interactions. The results indicate that PlexA1 interacts not only with Rnd1 but also with RhoD. Using a heterologous system (COS7 cells cotransfected with PlexA1 and NP1) which is thought to mimic growth cone collapse upon action of Sema 3A, combined with overexpression or dominant-negative approaches, the authors demonstrate that these GTPases have antagonistic effects on the activity of PlexA1.
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Zanata S.M., Hovatta I., Rohm B., Puschel A.W. Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Sema 3A-induced cytoskeletal collapse. J Neurosci. 15:2002;471-477. Here the authors used pull-down assays and screened a collection of GTPases to determine Plex interactions. The results indicate that PlexA1 interacts not only with Rnd1 but also with RhoD. Using a heterologous system (COS7 cells cotransfected with PlexA1 and NP1) which is thought to mimic growth cone collapse upon action of Sema 3A, combined with overexpression or dominant-negative approaches, the authors demonstrate that these GTPases have antagonistic effects on the activity of PlexA1.
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(2002)
J Neurosci
, vol.15
, pp. 471-477
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Zanata, S.M.1
Hovatta, I.2
Rohm, B.3
Puschel, A.W.4
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33
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0034192402
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The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP
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Pham N., Cheglakov I., Koch C.A., de Hoog C.L., Moran M.F., Rotin D. The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP. Curr Biol. 10:2000;555-568.
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(2000)
Curr Biol
, vol.10
, pp. 555-568
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Pham, N.1
Cheglakov, I.2
Koch, C.A.3
De Hoog, C.L.4
Moran, M.F.5
Rotin, D.6
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34
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0034678343
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Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse
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Fournier A.E., Nakamura F., Kawamoto S., Goshima Y., Kalb R.G., Strittmatter S.M. Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse. J Cell Biol. 149:2000;411-422.
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(2000)
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The authors used the terminal highly conserved C2 portion of the PlexA cytoplasmic domain to search for interacting proteins encoded by a Drosophila embryonic (0-24 hr) yeast two-hybrid cDNA library. They identify proteins belonging to the MICAL family of cytosolic, multidomain, flavoprotein monooxygenases. They provide evidence that MICAL acts in the same pathway as Sema1a and PlexA. Vertebrate orthologs of Drosophila MICAL are neuronally expressed and can interact with vertebrate Plexs. These results suggest a novel role for oxidoreductases in repulsive neuronal guidance.
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Terman J.R., Mao T., Pasterkamp R.J., Yu H.H., Kolodkin A.L. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. Cell. 109:2002;887-900. The authors used the terminal highly conserved C2 portion of the PlexA cytoplasmic domain to search for interacting proteins encoded by a Drosophila embryonic (0-24 hr) yeast two-hybrid cDNA library. They identify proteins belonging to the MICAL family of cytosolic, multidomain, flavoprotein monooxygenases. They provide evidence that MICAL acts in the same pathway as Sema1a and PlexA. Vertebrate orthologs of Drosophila MICAL are neuronally expressed and can interact with vertebrate Plexs. These results suggest a novel role for oxidoreductases in repulsive neuronal guidance.
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(2002)
Cell
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Terman, J.R.1
Mao, T.2
Pasterkamp, R.J.3
Yu, H.H.4
Kolodkin, A.L.5
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Mitsui N., Inatome R., Takahashi S., Goshima Y., Yamamura H., Yanagi S. Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. EMBO J. 21:2002;3274-3285.
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Takahashi, S.3
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Yanagi, S.6
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70
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Rac1-mediated endocytosis during Ephrin-A2- and Semaphorin 3A-induced growth cone collapse
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This study uses video time-lapse combined with Rac1-signaling-interfering peptide or antisense RNA on chicken dorsal root ganglion cultures. It shows that Rac1 does not regulate constitutive endocytosis in growth cones. In response to negative guidance molecules, the function of Rac1 changes from promoting actin polymerization associated with axon growth to driving endocytosis of the plasma membrane, resulting in growth cone collapse. These interesting data implicate Rac1 as a pivotal player in the coordination of cytoskelon modulation and endocytosis.
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Jurney W.M., Gallo G., Letourneau P.C., McLoon S.C. Rac1-mediated endocytosis during Ephrin-A2- and Semaphorin 3A-induced growth cone collapse. J Neurosci. 22:2002;6019-6028. This study uses video time-lapse combined with Rac1-signaling-interfering peptide or antisense RNA on chicken dorsal root ganglion cultures. It shows that Rac1 does not regulate constitutive endocytosis in growth cones. In response to negative guidance molecules, the function of Rac1 changes from promoting actin polymerization associated with axon growth to driving endocytosis of the plasma membrane, resulting in growth cone collapse. These interesting data implicate Rac1 as a pivotal player in the coordination of cytoskelon modulation and endocytosis.
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(2002)
J Neurosci
, vol.22
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Jurney, W.M.1
Gallo, G.2
Letourneau, P.C.3
McLoon, S.C.4
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71
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Growth cone collapse induced by semaphorin 3A requires 12/15-lipoxygenase
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Mikule K., Gatlin J.C., de la Houssaye B.A., Pfenninger K.H. Growth cone collapse induced by semaphorin 3A requires 12/15-lipoxygenase. J Neurosci. 22:2002;4932-4941.
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J Neurosci
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Mikule, K.1
Gatlin, J.C.2
De la Houssaye, B.A.3
Pfenninger, K.H.4
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72
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Dontchev2 and Paul C. Letourneau P: Nerve growth factor and Semaphorin 3A signaling pathways interact in regulating sensory neuronal growth cone motility
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Vassil D. Dontchev2 and Paul C. Letourneau P: Nerve growth factor and Semaphorin 3A signaling pathways interact in regulating sensory neuronal growth cone motility. J Neurosci. 22:2002;6659-6669.
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(2002)
J Neurosci
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Vassil, D.1
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