Intralesional corticosteroid treatment of multiple eruptive keratoacanthomas: Case report and review of a controversial therapy

Dermatologic Surgery

Volumn 28, Issue 10, 2002, Pages 954-958

  Sanders, Scott ^a,b   Busam, Klaus J ^a   Halpern, Allan C ^a   Nehal, Kishwer S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CORTICOSTEROID; DICLOXACILLIN; FLUOROURACIL; HYDROCORTISONE ACETATE; INTERFERON; LIDOCAINE; LITHIUM CARBONATE; METHOTREXATE; METICILLIN; PREDNISOLONE; RETINOID; TETRACYCLINE; TRIAMCINOLONE; TRIAMCINOLONE ACETONIDE; TRIAMCINOLONE DIACETATE; TRIAMCINOLONE HEXACETONIDE; VANCOMYCIN;

ADULT; ARTICLE; BIOPSY; BIPOLAR DISORDER; CASE REPORT; DRUG EFFECT; FEMALE; HUMAN; KERATOACANTHOMA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORBIDITY; PRIORITY JOURNAL; REMISSION; SCAR FORMATION; SIDE EFFECT; SKIN DISEASE; TREATMENT OUTCOME;

ARM; DERMATOLOGIC AGENTS; FEMALE; GLUCOCORTICOIDS; HUMANS; INJECTIONS, INTRALESIONAL; KERATOACANTHOMA; LEG; METHOTREXATE; MIDDLE AGED; TRIAMCINOLONE;

EID: 0036800728     PISSN: 10760512     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-4725.2002.02069.x     Document Type: Article

References (43)

1. Goette DK. Keratoacanthoma and its treatment. J Assoc Milit Dermatol 1984;10:3-10.
2. Hodak E, Jones RE, Ackerman AB. Solitary keratoacanthoma is squamous cell carcinoma: Three examples with metastasis. Am J Dermatopathol 1993;15:332-42.
3. Haydey RP, Reed ML, Dzubow LM, Shupack JL. Treatment of keratoacanthomas with oral 13-cis-retinoic acid. N Engl J Med 1980;303:560-62.
4. Tarnowski WM. Multiple keratoacanthoma: Response of a case to systemic chemotherapy. Arch Dermatol 1966;94:74-80.
5. Wickramasinghe L, Hindson TC, Wacks H. Treatment of neoplastic skin lesions with intralesional interferon. J Am Acad Dermatol 1989;20:71-4.
6. Valentine AD, Meyers CA, Kling MA, Richelson E, Hauser P. Mood and cognitive side effects of interferon-alpha therapy. Semin Oncol 1998;25:39-47.
7. Eberlein-Konig B, Hein R, Abeck D, Engst R, Ring J. Cutaneous sarcoid foreign body granulomas developing in sites of previous skin injury after systemic interferon-alpha treatment for chronic hepatitis C. Br J Dermatol 1999;140:370-72.
8. Sayama S, Tagami H. Treatment of keratoacanthoma with intralesional bleomycin. Br J Dermatol 1983;109:449-52.
9. Melton JL, Nelson BR, Stough DB, Brown M, Swanson NA, Johnson TM. Treatment of keratoacanthomas with intralesional methotrexate. J Am Acad Dermatol 1991;25:1017-23.
10. Cuesta-Romero C. Intralesional methotrexate in solitary keratoacanthoma. Arch Dermatol 1998;134:513-4.
11. Goette DK, Odom RB. Successful treatment of keratoacanthoma with intralesional fluorouracil. J Am Acad Dermatol 1980;2:212-6.
12. Eubanks SW, Gentry RH, Patterson JW, May DL. Treatment of multiple keratoacanthomas with intralesional fluorouracil. J Am Acad Dermatol 1982;7:126-9.
13. Parker CM, Hanke CW. Large keratoacanthomas in difficult locations treated with intralesional 5-fluorouracil. J Am Acad Dermatol 1986;14:770-77.
14. Belisario JC. Keratoacanthoma (molluscum sebaceum). In: Belisario JC, ed. Cancer of the Skin. London: Butterworth & Co., 1959;80-96.
15. McNairy DJ. Intradermal triamcinolone therapy of keratoacanthomas. Arch Dermatol 1964;89:136-40.
16. Burkett JA, Caplan RM. Multiple self-healing epithelioma. Arch Dermatol 1964;90:7.
17. Ereaux LP, Schopflocher P. Familial primary self-healing squamous epithelioma of skin: Ferguson-Smith type. Arch Dermatol 1965;91:589-94.
18. Freidman RP, Morales A, Burnham TR. Multiple cutaneous and conjunctival keratoacanthoma. Arch Dermatol 1965;92:162.
19. Belisario JC. Brief review of keratoacanthomas and description of keratoacanthoma centrifugum marginatum. Australas J Dermatol 1965;8:65-72.
20. Jolly HW, Carpenter CL. Multiple keratoacanthomata: A report of two cases. Arch Dermatol 1966;93:348-53.
21. Reager LL. Multiple keratoacanthomas of Ferguson-Smith. Arch Dermatol 1968;98:432-4.
22. Epstein EH Jr, Epstein EH. Keratoacanthoma recurrent after surgical excision. J Dermatol Surg Oncol 1978;4:524-5.
23. Reid BJ, Cheesbrough MJ. Multiple keratoacanthomata. A unique case and review of the current classification. Acta Derm Venereol 1978;58:169-73.
24. Cipollaro VA. The use of podophyllin in the treatment of keratoacanthoma. Int J Dermatol 1983;22:436-40.
25. Kingman J, Callen JP. Keratoacanthoma: A clinical study. Arch Dermatol 1984;120:736-40.
26. Consigli JE, Gonzalez ME, Morsino R, et al. Generalized eruptive keratoacanthoma (Grzybowski variant). Br J Dermatol 2000;142:800-803.
27. Ghadially FN. The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals. Cancer 1961;14:801-16.
28. Zachariae L, Asboe-Hansen G. Regression of experimental skin tumors in mice following local injections of 17 hydroxycorticosterone-21-acetate. Cancer Res 1954;14:488.
29. Asboe-Hansen G, Zachariae L. Mast cell changes induced by hydrocortisone acetate in experimental animals. Acta Path Microbiol Scand 1955;37:145.
30. Anderson NP. Multiple primary self-healing squamous-cell "epitheliomas" of the skin: Generalized keratoacanthoma. Arch Dermatol 1957;75:210-23.
31. Patel A, Halliday GM, Cooke BE, Barnetson RS. Evidence that regression in keratoacanthoma is immunologically mediated: A comparison with squamous cell carcinoma. Br J Dermatol 1994;131:789-98.
32. Dessoukey MW, Omar MF, Abdel-Dayem H. Eruptive keratoacanthomas associated with immunosuppressive therapy in a patient with systemic lupus erythematosus. J Am Acad Dermatol 1997;37:478-80.
33. Ephraim AJ, Kaufman JJ. Multiple keratoacanthoma. Arch Dermatol 1958;77:191-4.
34. Santoso-Pham JC, Shelley ED, Shelley WB. Aggressive giant keratoacanthoma of the face treated with intramuscular methotrexate and triamcinolone acetonide. Cutis 1997;59:329-32.
35. Sirsat SM, Ketkar MB. Influence of DOCA on induced epidermal cancers in mice. J Invest Dermatol 1966;46:331-40.
36. Stenn KS, Paus R, Dutton T, Sarba B. Glucocorticoid effect on hair growth initiation: A reconsideration. Skin Pharmacol 1993;6:125-34.
37. Miller SJ, Wei ZG, Wilson C, Dzubow L, Sun TT, Lavker RM. Mouse skin is particularly susceptible to tumor initiation during early anagen of the hair cycle: Possible involvement of hair follicle stem cells. J Invest Dermatol 1993;101:591-4.
38. Lawrence N, Reed RJ. Actinic keratoacanthoma: Speculations on the nature of the lesion and the role of cellular immunity in its evolution. Am J Dermatopathol 1990;12:517-33.
39. Fisher LB, Maibach HI. The effect of corticosteroids on human epidermal mitotic activity. Arch Dermatol 1971;103:39-44.
40. Schwarz JA, Viaje A, Slaga TJ. Fluocinolone acetonide: A potent inhibitor of mouse skin tumor promotion and epidermal DNA synthesis. Chem Biol Interact 1977;17:331-47.
41. Lee SW, Morhenn VB, Ilnicka M, Eugui EM, Allison AC. Autocrine stimulation of interleukin-1α and transforming growth factor-α production in human keratinocytes and its antagonism by glucocorticoids. J Invest Dermatol 1991;97:106-10.
42. Finzi E, Kilkenny A, Strickland JE, et al. TGF alpha stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression. Mol Carcinog 1988;1:7-12.
43. Finzi E, Ho T, Anhalt G, et al. Localization of transforming growth factor alpha in human appendageal tumors. Am J Pathol 1992;141:643-53.