Gut mucosal immunity to tissue transglutaminase in untreated celiac disease and other gastrointestinal disorders

Digestive Diseases and Sciences

Volumn 47, Issue 10, 2002, Pages 2325-2335

  Dahele, Anna ^a   Aldhous, Marian C ^a   Kingstone, Kathleen ^a   Humphreys, Kennneth ^a   Bode, John ^a   McIntyre, Margaret ^b   Ghosh, Subrata ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Anti tissue transglutaminase antibody; Celiac disease; Tissue transglutaminse; Whole gut lavage

Indexed keywords

ENDOMYSIUM ANTIBODY; ENZYME ANTIBODY; IMMUNOGLOBULIN A ANTIBODY; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; ENTEROPATHY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNITY; INTESTINE LAVAGE; INTESTINE MUCOSA; MALE; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AUTOANTIBODIES; CELIAC DISEASE; FEMALE; GASTROINTESTINAL DISEASES; GTP-BINDING PROTEINS; HUMANS; IMMUNOGLOBULIN A; INTESTINAL MUCOSA; INTESTINES; IRRIGATION; MALE; MIDDLE AGED; TRANSGLUTAMINASES;

EID: 0036799560     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020155831849     Document Type: Article

References (36)

1. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D: Identification of tissue transglutaminase as the autoantigen of coeliac disease. Nat Med 3(7):797-801, 1997
2. Sulkanen S, Halttunen T, Laurila K, Kolho K, Korponay-Szabo IL, Sarnesto A, Savilahti E, Collin P, Maki M: Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology 115(6):1322-1328, 1998
3. Dieterich W, Laag E, Schopper H, Volta U, Ferguson A, Gillett H, Riecken EO, Schuppan D: Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 115(6):1317-1321, 1998
4. Lock RJ, Pitcher MCL, Unsworth DJ: IgA tissue transglutaminase as a diagnostic marker of gluten sensitive enteropathy. J Clin Pathol 52:274-277, 1999
5. Troncone R, Maurano F, Rossi M, Micillo M, Greco L, Auricchio S, Salerno G, Salvatore F, Sacchetti L: IgA antibodies to tissue transglutaminase: An effective diagnostic test for celiac disease. J Pediatr 134:166-171, 1999
6. Biagi F, Ellis HJ, Yiannakou JY, Brusco G, Swift GL, Smith PM, Corazza GR, Ciclitira PJ: Tissue transglutaminase antibodies in celiac disease. Am J Gastroenterol 94(8):2187-2192, 1999
7. Folk JE: Structure and catalytic properties of hepatic transglutaminase. Ann NY Acad Sci 202:59-76, 1972
8. Upchurch HF, Conway E, Patterson MK Jr., Birckbichler PJ, Maxwell MD: Cellular transglutaminase has affinity for extracellular matrix. In Vitro Cell Dev Biol 23(11):795-799, 1987
9. Patel EK, Bruce SE, Bjarnason I, Peters TJ: Rat gastrointestinal transglutaminase: Demonstration of enzyme activity and cell and tissue distributions. Cell Biochem Funct 3:199-203, 1985
10. Bruce SE, Bjarnason I, Peters TJ: Human jejunal transglutaminase: Demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and coeliac disease. Clin Sci 68:573-579, 1985
11. Molberg O, Mcadam SN, Korner R, Quarsten H, Kristiansen C, Madsen L, Fugger L, Scott H, Noren O, Roepstorff P, Lundin KEA, Sjostrom H, et al: Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 4(6):713-717, 1998
12. Lundin KEA, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, Thorsby E, Sollid LM: Gliadin-specific, HLA-DQ(a1*0501, b1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 178:187-196, 1993
13. Molberg O, Kett K, Scott H, Thorsby E, Sollid LM, Lundin KEA: Gliadin specific, HLA DQ2-restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls. Scand J Immunol 46:103-108, 1997
14. Sollid LM, Molberg O, McAdam S, Lundin KEA: Autoantibodies in coeliac disease: Tissue transglutaminase-guilt by association? Gut 41:851-852, 1997
15. O'Mahony S, Arranz E, Barton JR, Ferguson A: Dissociation between systemic and mucosal humoral immune responses in coeliac disease. Gut 32(1):29-35, 1991
16. Challacombe SJ. Assessing mucosal humoral immunity. Clin Exp Immunol 100:181-182, 1995
17. O'Mahony S, Barton JR, Crighton S, Ferguson A: Appraisal of gut lavage in the study of intestinal humoral immunity. Gut 31:1341-1344, 1990
18. Choudari CP, O'Mahony S, Brydon G, Mwantembe O, Ferguson A: Gut lavage fluid protein concentrations: Objective measures of disease activity in inflammatory bowel disease. Gastroenterology 104(4):1064-1071, 1993
19. Brydon WG, Choudari CP, Ferguson A: Relative specificity for active inflammatory bowel disease of plasma-derived proteins in gut lavage fluid. Eur J Gastroenterol Hepatol 5:269-273, 1993
20. Gaspari MM, Brennan PT, Solomon SM, Elson CO: A method of obtaining, processing, and analyzing human intestinal secretions for antibody content. J Immunol Methods 110:85-91, 1988
21. Brown WR, Newcomb RW, Ishizaka K: Proteolytic degradation of exocrine and serum immunoglobulins. J Clin Invest 49:1374-1380, 1970
22. Jones RG, Payne RB: Data for diagnosis and monitoring. In Clinical Investigation and Statistics in Laboratory Medicine. RG Jones, RB Payne, (eds). London, ACB Venture, 1997, pp. 66-123
23. Bell JL, Todd JA, McDevitt HO: The molecular basis of HLA-disease association. Adv Hum Genet 18:1-41, 1989
24. Larhammar D, Hyldig-Nielsen JJ, Servenius B: Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene. Proc Natl Acad Sci USA 95:78-82, 1983
25. Kelly CP, Feighery C, Gallagher RB, Gibney MJ, Weir DG: Mucosal and systemic IgA anti-gliadin antibody in celiac disease. Contrasting patterns of response in serum, saliva, and intestinal secretions. Dig Dis Sci 36(6):743-751, 1991
26. Engstrom PE, Sundin U, Lavo B, Norhagen G, Hallgren R, Smith CIE: Class and subclass-associated specificity differences of anti-gliadin antibodies from mucosa and serum. Immunology 77:604-608, 1992
27. Lancaster-Smith M, Kumar P, Marks R, Clark ML, Dawson AM: Jejunal mucosal immunoglobulin-containing cells and jejunal fluid immunoglobulins in adult coeliac disease and dermatitis herpetiformis. Gut 15:371-376, 1974
28. Volta U, Molinaro N, Fratangelo D, Bianchi FB: IgA subclass antibodies to gliadin in serum and intestinal juice of patients with coeliac disease. Clin Exp Immunol 80:192-195, 1990
29. Mwantembe O: The immunological effects of elemental diets in inflammatory bowel disease. Edinburgh, University of Edinburgh, 1992, 179 pp
30. Colombel JF, Mascart-Lemone F, Nemeth J, Vaerman JP, Dive C, Rambaud JC: Jejunal immunoglobulin and antigliadin antibody secretion in adult coeliac disease. Gut 31:1345-1349, 1990
31. Crabbe PA, Carbonara AO, Heremans JF: The normal human intestinal mucosa as a major source of plasma cells containing gamma-A-immunoglobulin. Lab Invest 14(3):235-248, 1965
32. Rosekrans PCM, Meijer CJLM, Van Der Wal AM, Cornelisse CJ, Lindeman J: Immunoglobulin containing cells in inflammatory bowel disease of the colon: A morphometric and immunohistochemical study. Gut 21:941-947, 1980
33. Ferguson A, Humphreys K, Croft N. Technical reports: Results of immunological tests on faecal extracts are likely to be extremely misleading. Clin Exp Immunol 99:70-75, 1995
34. Collin P, Maki M, Keyrilainen O, Hallstrom O, Reunala T, Pasternack A: Selective IgA deficiency and coeliac disease. Scand J Gastroenterol 27:367-371, 1992
35. Webster ADB, Slavin G, Shiner M, Platts-Mills TAE, Asherson GL: Coeliac disease with severe hypogammaglobulinaemia. Gut 22:153-157, 1981
36. Halttunen T, Maki M: Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation. Gastroenterology 116:566-572, 1999