Lovastatin alters biliary lipid composition and dissolves gallstones: A long-term study in prairie dogs

Digestive Diseases and Sciences

Volumn 47, Issue 10, 2002, Pages 2192-2210

  Abedin, Mohammad Z ^a   Narins, Seth C ^a   Park, Eun H ^a   Smith, Peter R ^b   Kirkwood, Kimberly S ^c  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bile acids; Cholesterol; Dissolution; Gallstones; Lovastatin; Prairie dogs

Indexed keywords

CHOLESTEROL; MEVINOLIN; URSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; CHOLELITHIASIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DISSOLUTION; DOG; GALLSTONE; LIPID COMPOSITION; MALE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BILE; BILE ACIDS AND SALTS; CHOLELITHIASIS; CHOLESTEROL; CHOLESTEROL, DIETARY; DRUG INTERACTIONS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MALE; SCIURIDAE; URSODEOXYCHOLIC ACID;

EID: 0036798438     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020174908650     Document Type: Article

References (56)

1. Diehl A: Epidemiology and natural history of gallstone disease. Gastroenterol Clin North Am 20:1-19, 1991
2. NIH CDP: Gallstones and laparoscopic cholecystectomy. JAMA 269(8):1018-1024, 1993
3. Lagergren J, Ye W, Ekbom A: Intestinal cancer after cholecystectomy: is bile involved in carcinogenesis? Gastroenterology 121:542-547, 2001
4. Freedman J, Ye W, Naaslund E, Lagergren J: Association between cholecystectomy and adenocarcinoma of the esophagus. Gastroenterology 121:548-553, 2001
5. Salen G, Colalillo A, Verga D, Bagan E, Tint GS, Shefer S: Effect of high and low doses of ursodeoxycholic acid on gallstone dissolution in humans. Gastroenterology 78:1412-1418, 1980
6. Shoenfield LJ, Lachin JM: The steering committee: chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study. A controlled trial of efficacy and safety. Ann Intern Med 95:257-282, 1981
7. Roda E, Bazzoli F, Labate AM, Mazzella G, Roda A, Sama C, Festi D, Aldini R, Taroni F, Barbara L: Ursodeoxycholic acid vs chenodeoxycholic acid as cholesterol gallstone-dissolving agents: a comparative randomized study. Hepatology 2:804-810, 1982
8. Admirand WH, Small DM: The physiochemical basis of cholesterol gallstone formation in man. J Clin Invest 47:1043-1052, 1968
9. Angelin B, Ewerth S, Einarsson K: Ursodeoxycholic acid treatment in cholesterol gallstone disease: effects on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, biliaryn-lipid composition and plasma lipid levels. J Lipid Res 24:461-468, 1983
10. Staffan S, Thyberg P, Ahlberg J, Angelin B, Einarsson K: Distribution of cholesterol between vesicles and micelles in human gallbladder bile: influence of treatment with chenodeoxycholic acid and ursodeoxycholic acid. Hepatology 13:104-110, 1991
11. Hofmann AF: Rationale of bile acid therapy after biliary lithotripsy. In Biliary Lithotripsy. JT Ferrucci, M Delius, HJ Burhenne (eds). Chicago, Year Book Mediacl Publishers, 1989, pp 151-157
12. Sackmann M, Delius M, Sauerbruch T, Holl J, Weber W, Ippisch E, Hagelauer U, Wess O, Hepp W, Brendel W: Shockwave lithotripsy of gallbladder stones-the first 175 patients. N Engl J Med 318:393-397, 1988
13. Erlinger S, Go AL, Husson JM, Fevery J: Franco-Belgian cooperative study of ursodeoxycholic acid in the medical dissolution of gallstones: a double-blind, randomized, dose-response study, and comparison with chenodeoxycholic acid. Hepatology 4:308-314, 1984
14. Fromm H, Roat JW, Gonzalez V, Sarva RJ, Farivar S: Comparative efficacy and side effects of ursodeoxycholic and chenodeoxycholic acids in dissolving gallstones: a double blind controlled study. Gastroenterology 85:1257-1264, 1983
15. Bachrach WH, Hofmann AF: Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Dig Dis Sci 27:737-856, 1982
16. Alberts AW, Chen J, Kuron G, Hung V, Huff J, Hoffman C, Rothrock J, Lopez M, Joshua H, Harris E, Patchett A, Monaghan R, Currie S, Stapley E, Albershonberg G, Hensens O, Hirshfield J, Hoogsteen K, Liesch J, Springer J: Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci USA 77:3957-3961, 1980
17. Havel RJ, Hunninghake DB, Illingworth DR, Lees RS, Stein EA, Tobert JA, Bacon SR, Bolognese JA, Frost PH, Lamkin GE: Lovastatin (mevinolin) in the treatment of heterozygous familial hypercholesterolemia. A multicenter study. Ann Intern Med 107:609-615, 1987
18. Bilheimer DW: Long-term clinical tolerance of lovastatin and simvastatin. Cardiology 77:58-65, 1990
19. Pertsemlidis DE, Panveliwaila D, Ahrens AH Jr: Effects of clofibrate and an estrogen-progestin combination of fasting biliary lipids and cholic acid kinetics in man. Gastroenterology 66:565-573, 1974
20. The Coronary Drug Project Research Group CDP: Clofibrate and niacin in heart disease. JAMA 231:360-381, 1975
21. Duane WC, Hunninghake DB, Freeman ML, Pooler PA, Schlasner LA, Gebhard RL: Simvastatin, a competive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bile. Hepatology 8:1147-1150, 1988
22. Logan GM, Duane WC: Lovastatin added to ursodeoxycholic acid further reduces biliary cholesterol saturation. Gastroenterology 98:1572-1576, 1990
23. Carulli N, Ponz de Leon M, Zironi F, Pinetti A, Smerieri A, Iori R, Loria P: Hepatic cholesterol and bile acid metabolism in subjects with gallstones: comparative effects of short term feeding of chenodeoxycholic and ursodeoxycholic acid. J Lipid Res 21:35-43, 1980
24. Saunders KD, Cates JA, Abedin MZ, Rege S, Festekdjian SF, Howard W, Roslyn JJ: Lovastatin inhibits gallstone formation in the cholesterol-fed prairie dog. Ann Surg 214(2):149-154, 1991
25. Saunders KD, Cates JA, Abedin MZ, Roslyn JJ: Lovastatin and gallstone dissolution: a preliminary study. Surgery 113(1):28-35, 1993
26. Sackmann M, Koelble R, Pauletzki J, Cremer P, Kluppelberg UG, von Ritter C, Sauter G, Holl J, Siedel D, Paumgartner G: Simvastain added to ursodeoxycholic acid does not enhance disappearance of gallstone fragments after shockwave therapy. Z Gastroenterol 33:585-589, 1995
27. Glasonovic JC, Scrivanti M, Mege RM, Raddatz O, Alvarado A, Validivia MT, Ahumada E: Gallstone dissolution in an adult female population: trial with lovastatin therapy. Rev Med Chile 124(7):793-798, 1996
28. Tazuma S, Kajiyama G, Mizuno T, Yamashita G, Miura H, Kajihara T, Hattori Y, Miyake H, Nishioka T, Hyogo H, Sunami Y, Yasumiba S, Ochi H, Matsumoto T, Abe A, Adachi K, Omatta F, Ueno F, Ohguri S, Shibata H, Kokubu H: A combination therapy with simvastatin and ursodeoxycholic acid is more effective for cholesterol gallstone dissolution than ursodeoxycholic acid monotherapy. J Clin Gastroenterol 26:287-291, 1998
29. Gurll N, DenBesten L: Animal models of human cholesterol gallstone disease: a review. Lab Anim Sci 28(4):428-432, 1978
30. Holzbach RT: Animal models of cholesterol gallstone disease. Hepatology 4(5 suppl):191S-198S, 1984
31. Brenneman DE, Connor WE, Forker EL, DenBesten L: The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog. J Clin Invest 51(6):1495-1503, 1972
32. DenBesten L, Safaie-Shirazi S, Connor WE, Bell S: Early changes in bile composition and gallstone formation induced by a high cholesterol diet in prairie dogs. Gastroenterology 66(5):1036-1045, 1974
33. Roschlau P, Bernt E, Gruber W: Cholesterol and esterified cholesterol. In Methods of Enzymatic Analysis, Vol 4. HU Bergmeyer (ed). New York, Academic Press, 1974, pp 1890-1893
34. Dryer RL, Tammes AR, Routh JI: The determination of phosphorus and phosphatase with N-phenyl-p-phenylene diamine. J Biol Chem 225:177-183, 1957
35. Iwata T, Yamasaki K: Enzymatic determination and TLC of bile acids in blood. J Biochem 56:424-431, 1964
36. Anderegg C, Flaschka H, Sallman R, Schwarzenback GM: Metallindikatoren IV. Ein auf erdkaliionen ansprechendes phtalien und seine analytische Verwendung. Helv Chim Acta 37:113-120, 1951
37. Connerty HV, Briggs AR: Determination of serum calcium by means of orthocresolphthalein complexone. Am J Clin Pathol 45(3):290-296, 1966
38. Carey MC: Critical tables for calculating the cholesterol saturation of native bile. J Lipid Res 19(8):945-955, 1978
39. Nakayama F, Nakagaki M: Quantitative determination of bile acids in bile with reversed-phase high performance liquid chromatography. J Chromatogr 183:287-293, 1980
40. Abedin MZ, Strichartz SD, Festekdjian S, Roslyn JJ: Increased biliary calcium in cholesterol and pigment gallstone disease: the role of altered bile acid composition. Lipids 24(7):572-578, 1989
41. Radin NS: Extraction of tissue lipids with a solvent of low toxicity. Methods Enzymol 72:5-10, 1981
42. Roslyn JJ, Conter RL, Julian E, Abedin MZ: The role of dietary iron in pigment gallstone formation. Surgery 102:327-333, 1987
43. Strichartz SD, Abedin MZ, Abdou MS, Roslyn JJ: Increased biliary calcium in cholesterol gallstone formation. Am J Surg 155(1):131-137, 1988
44. Carey MC, Small DM: The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man. J Clin Invest 61 (4):998-1026, 1978
45. Podda M, Zuin M, Battezzati PM, Ghezzi C, Fazio CD, Dioguardi ML: Efficacy and safety of a combination of chenodeoxycholic acid and ursodeoxycholic acid for gallstone dissolution: a comparison with ursodeoxycholic acid alone. Gastroenterology 96:222-229, 1989
46. Park YH, Igimi H, Carey MC: Dissolution of human cholesterol gallstones in stimulated chenodeoxycholate-rich and ursodeoxycholate-rich biles. An in vitro study of dissolution rates and mechanisms. Gastroenterology 87(1):150-158, 1984
47. Corrigan OI, Su SC, Higuchi WI, Hofmann AF: Mesophase formation during cholesterol gallstone dissolution in ursodeoxycholate-lecithin solution: new mechanis for gallstone dissolution in humans. J Pharmacol Sci 69:869, 1980
48. Carey MC, Grace KO: The importance of total lipid concentration in determining cholesterol solubility in bile and the development of critical table for calculating percent cholesterol saturation with a correction factor for ursodeoxycholate-rich bile. In Biological Effects of Bile Acids. G Paumgartner, A Steihl, W Gerok (eds). Lancaster, England, MTP, 1979, pp 299-308
49. Stiehl A, Raedsch R, Czygan P, Gotz R, Manner CH, Walker S, Kommerel B: Effects of biliary bile acid composition on biliary cholesterol saturation in gallstone patients treated with chenodeoxycholic acid and/or ursodeoxycholic acid. Gastroenterology 79:1192-1198, 1980
50. Thomas PJ, Hofmann AF: A simple calculation of lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates. Gastroenterology 65:898-700, 1973
51. Krukemeyer JJ, Talbert RL: Lovastatin: a new cholesterol lowering agent. Pharmacotherapy 7:198-210, 1987
52. Stone BG, Erickson SK, Craig WY, Cooper AD: Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism. J Clin Invest 76:1773-1781, 1985
53. Nilsell K, Angelin B, Leijd B, Finnarsson K: Comparative effects of ursodeoxycholic acid and chenodeoxycholic acid on bile acid kinetics and biliary lipid secretion in humans: evidence for different modes of action on bile acid synthesis. Gastroenterology 85:1248-1256, 1983
54. von Bergmann K, Epple-Gusfeld M, Leiss O: Differences in the effects of chenodeoxycholic acid and ursodeoxycholic acid on biliary lipid secretion and bile acid synthesis in patients with gallstones. Gastroenterology 87:136-143, 1984
55. Leiss O, von Bergman K, Streicher V, Stotkoetter H: The effect of three different dihydroxy bile acids on intestinal cholesterol absorption in normal volunteers. Gastroenterology 87:144-149, 1984
56. Tint GS, Salen G, Shefer S: Effect of ursodeoxycholic and chenodeoxycholic acid on cholesterol and bile acid metabolism. Gastroenterology 91:1007-1018, 1986