Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?

Thrombosis and Haemostasis

Volumn 88, Issue 4, 2002, Pages 587-591

  Oger, Emmanuel ^a   Lacut, Karine ^a   Le Gal, Grégoire ^a   Van Dreden, Patrick ^a   Bressollette, Luc ^a   Scarabin, Pierre Yves ^a   Leroyer, Christophe ^a   Mottier, Dominique ^a  

^a SERVICE DE RHUMATOLOGIE   (France)

Author keywords

APC resistance; Elderly; Venous thrombosis

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5 LEIDEN; DNA; BLOOD CLOTTING FACTOR 5;

ACTIVATED PROTEIN C RESISTANCE; ADULT; AGED; ARTICLE; CANCER SURGERY; CASE CONTROL STUDY; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DELIVERY; ELDERLY CARE; EMBOLISM; FEMALE; GENETIC ANALYSIS; HEMIPARESIS; HIGH RISK POPULATION; HUMAN; LEG INJURY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; PREGNANCY; PRIORITY JOURNAL; RISK FACTOR; STROKE; VEIN THROMBOSIS; AGE; ANALYSIS OF VARIANCE; MIDDLE AGED; THROMBOEMBOLISM;

ACTIVATED PROTEIN C RESISTANCE; AGE FACTORS; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; FACTOR V; FEMALE; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; THROMBOEMBOLISM; VENOUS THROMBOSIS;

EID: 0036797530     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613260     Document Type: Article

References (34)

1. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet 1999; 353: 1167-1173.
2. Dahlback B. Resistance to activated protein C as risk factor for thrombosis: molecular mechanisms, laboratory investigation, and clinical management. Semin Hematol 1997; 34: 217-34.
3. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, De Ronde H, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
4. Koster T, Rosendaal FR, De Ronde H, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 1503-6.
5. Svensson PJ, Dahlback B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994; 330: 517-22.
6. Desmarais S, De Moerloose P, Reber G, Minazio P, Perrier A, Bounameaux H. Resistance to activated protein C in an unselected population of patients with pulmonary embolism. Lancet 1996; 347: 1374-5.
7. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 85: 1504-8.
8. Baglin TP, Brown K, Williamson D, Baker P, Luddington R. Relative risk of pulmonary embolism and deep vein thrombosis in association with the factor V Leiden mutation in a United Kingdom population [letter]. Thromb Haemost 1997; 77: 1219.
9. Leroyer C, Mercier B, Escoffre M, Ferec C, Mottier D. Factor V Leiden prevalence in venous thromboembolism patients. Chest 1997; 111: 1603-6.
10. Martinelli I, Cattaneo M, Panzeri D, Mannucci PM. Low prevalence of factor V: Q506 in 41 patients with isolated pulmonary embolism. Thromb Haemost 1997; 77: 440-3.
11. Ehrenforth S, Zwinge B, Scharrer I. High prevalence of factor V R506Q mutation in German thrombophilic and normal population [letter]. Thromb Haemost 1998; 79: 684-5.
12. Olafsson I, Hjaltadottir S, Onundarson PT, Porarinsdottir R, Haraldsdottir V. Prevalence of factor V(Q506) and prothrombin 20210 A mutations in an apparently healthy Icelandic population and patients suffering from venous thrombosis [letter]. Thromb Haemost 1998; 79: 685-6.
13. Alhenc-Gelas M, Arnaud E, Nicaud V, Aubry ML, Fiessinger JN, Aiach M, et al. Venous thromboembolic disease and the prothrombin, methylene tetrahydrofolate reductase and factor V genes. Thromb Haemost 1999; 81: 506-10.
14. Lindmarker P, Schulman S, Sten-Linder M, Wiman B, Egberg N, Johnson H. The risk of recurrent venous thromboembolism in carriers and non-carriers of the G1691A allele in the coagulation factor V gene and the G20210A allele in the prothrombin gene. DURAC Trial Study Group. Duration of Anticoagulation. Thromb Haemost 1999; 81: 684-9.
15. Salomon O, Steinberg DM, Zivelin A, Gitel S, Dardik R, Rosenberg N, et al. Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment. Arterioscler Thromb Vasc Biol 1999; 19: 511-8.
16. Bjorgell O, Nilsson PE, Nilsson JA, Svensson PJ. Location and extent of deep vein thrombosis in patients with and without FV: R 506Q mutation. Thromb Haemost 2000; 83: 648-51.
17. De Moerloose P, Reber G, Perrier A, Perneger T, Bounameaux H. Prevalence of factor V Leiden and prothrombin G20210A mutations in unselected patients with venous thromboembolism. Br J Haematol 2000; 110: 125-9.
18. Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995; 332: 912-7.
19. Rodeghiero F, Tosetto A. Activated protein C resistance and factor V Leiden mutation are independent risk factors for venous thromboembolism. Ann Intern Med 1999; 130: 643-50.
20. Ridker PM, Glynn RJ, Miletich JP, Goldhaber SZ, Stampfer MJ, Hennekens CH. Age-specific incidence rates of venous thromboembolism among heterozygous carriers of factor V Leiden mutation. Ann Intern Med 1997; 126: 528-31.
21. Oger E, Leroyer C, Bressollette L, Nonent M, Le Moigne E, Bizais Y, et al. Evaluation of a new, rapid, and quantitative D-Dimer test in patients with suspected pulmonary embolism. Am J Respir Crit Care Med 1998; 158: 65-70.
22. The PIOPED Investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism. JAMA 1990; 263: 2753-9.
23. Oger E, Leroyer C, Mercier B, van Dreden P, Bressollette L, Saint-Martin L, et al. Assessment of activated protein C resistance using a new and rapid venom-based test: STA Staclot APC-R. Blood Coagul Fibrinolysis 1998; 9: 355-9.
24. Faure-Delanef L, Quere I, Zouali H, Cohen D. Human longevity and R506Q factor V gene mutation [letter]. Thromb Haemost 1997; 78: 1160.
25. McNerlan SE, Crawford VL, Stout RW. Factor V Leiden in a healthy Northern Ireland elderly population [letter]. Age Ageing 1997; 26: 408-9.
26. Rees DC, Liu YT, Cox MJ, Elliott P, Wainscoat JS. Factor V Leiden and thermolabile methylenetetrahydrofolate reductase in extreme old age. Thromb Haemost 1997; 78: 1357-9.
27. Heijmans BT, Westendorp RG, Knook DL, Kluft C, Slagboon PE. The risk of mortality and the factor V Leiden mutation in a population-based cohort. Thromb Haemost 1998; 80: 607-9.
28. Cushman M, Rosendaal FR, Psaty BM, Cook EF, Valliere J, Kuller LH, et al. Factor V Leiden is not a risk factor for arterial vascular disease in the elderly: results from the Cardiovascular Health Study. Thromb Haemost 1998; 79: 912-5.
29. Koeleman BP, Reitsma PH, Allaart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 1994; 84: 1031-5.
30. Zoller B, Berntsdotter A, Garcia dF, Dahlback B. Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S. Blood 1995; 85: 3518-23.
31. Ehrenforth S, Ludwig G, Klinke S, Krause M, Scharrer I, Nowak-Gottl U. The prothrombin 20210 A allele is frequently coinherited in young carriers of the factor V Arg 506 to Gln mutation with venous thrombophilia. Blood 1998; 91: 2209-10.
32. Zoller B, Garcia dF, Hillarp A, Dahlback B. Thrombophilia as a multigenic disease. Haematologica 1999; 84: 59-70.
33. Middeldorp S, Henkens CM, Koopman MM, van Pampus EC, Hamulyak K, van der Meer J, et al. The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis. Ann Intern Med 1998; 128: 15-20.
34. Simioni P, Sanson BJ, Prandoni P, Tormene D, Friedrich PW, Girolami B, et al. Incidence of venous thromboembolism in families with inherited thrombophilia. Thromb Haemost 1998; 81: 198-202.